Mind-body intervention for people with Long COVID

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a mind-body intervention in alleviating symptoms associated with Long COVID. Participants will be randomly assigned to receive either the mind-body intervention, usual care, or an active control intervention. The primary focus is on reducing somatic symptoms and improving daily functioning in individuals suffering from Long COVID. The study will also assess the impact of the intervention on specific somatic complaints compared to the control groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult (≥ 18 years of age)
2. Infection with Sars-COV2 (i. e., positive antibody, antigen, or PCR testing)
3. Symptoms attributed only to COVID-19 and not to known comorbid disease (e.g., other infections, cancer, etc)
4. A somatic symptom score ≥ 10 on the SSS-8 questionnaire with involvement of at least 3 domains
5. Symptoms present at least 3 day a week for a minimum of 3 months
6. Willingness to engage in a Mind-Body intervention

Exclusion Criteria:

1. Clear diagnosis of physical disease (e.g. lung fibrosis, myocarditis) not inclusive of non-specific findings such as mild arthritis
2. Hospitalization in an intensive care unit for acute COVID-19 infections
3. Age greater than 65 years
4. Diagnosis of dementia or similar cognitive impairment
5. Active addiction disorder (e.g. cocaine) that would interfere with study participation
6. Major psychiatric comorbidity (e.g., schizophrenia). Mild to moderate anxiety and depression are not considered in this category

Where it's running

• Beth Israel Deaconess Medical Center
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Michael Donnino, MD — Beth Israel Deaconess Medical Center
• Study coordinator: Ashley Scafetta
• Email: ascafett@bidmc.harvard.edu
• Phone: 617-754-2882

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Combination therapy for Long COVID symptoms using valacyclovir, celecoxib, and Paxlovid

  This study tests whether a three-drug combination can reduce Long COVID symptoms in adults compared with a placebo.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07597902

• Long COVID relief through learning mindfulness

  This study will try an 8-week online recorded mindfulness program to see if it reduces stress and Long COVID symptoms in adults who continue their usual care.

  Recruiting Columbia University · New York, New York · NCT07140094

• Hi-OxSR to treat post-COVID cognitive problems

  This trial will test whether using the Hi-OxSR breathing device can help adults with long COVID who have ongoing cognitive problems and fatigue.

  Recruiting at 3 sites University Health Network, Toronto · Edmonton, Alberta and 2 other locations · NCT06928506

• Imaging brain inflammation in people with long COVID symptoms

  This study is testing if a brain scan can show signs of inflammation in people aged 18 to 70 who have neurological symptoms after COVID-19, and whether a treatment called IVIg can help them feel better.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06920628

• Hyperbaric oxygen therapy for Long COVID cognitive symptoms

  This study will test whether hyperbaric oxygen therapy can improve lingering cognitive symptoms like brain fog and memory problems in adults who had COVID-19.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06452095

• Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

  This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

  Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.