Non-invasive treatment for brain fog in Long COVID patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of both acute and chronic exposure to hypoxia and hypercapnia on patients suffering from Long COVID syndrome, specifically targeting symptoms like brain fog. Participants will undergo various interventions, including acute placebo visits and progressive carbon dioxide exposure, to assess their impact on brain blood flow and heart rate variability. The study aims to provide insights into non-invasive treatment options for managing fatigue and cognitive difficulties associated with Long COVID.

Why it matters

Who can join: the full rules

Inclusion criteria:

* English speaking
* Diagnosis of Long COVID

Exclusion criteria:

* Any history of:

  * Coronary artery dissection or aortic dissection
  * Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease)
  * Cerebrovascular disease or stroke
  * Aneurysm
* If currently has:

  * Moderate-severe chronic obstructive pulmonary disease
  * Uncontrolled moderate-severe asthma
  * Moderate-severe bronchiectasis
  * Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
  * A necessity to use supplemental oxygen, for any reason
  * New or worsening symptoms (decompensation) of heart failure
  * Right heart disease due to chronic pulmonary disease/sleep apnea
  * Uncontrolled myocardial ischemia or angina
  * Uncontrolled heart arrhythmias
  * Heart or lung infection (e.g. myocarditis or pericarditis)
  * Left main coronary artery stenosis
  * Moderate-severe aortic stenosis
  * Pulmonary embolism, pulmonary infarction, or other blood clots
  * Severe respiratory disease
  * Chronic kidney disease
  * Chronic liver disease
* Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy
* BMI \>40
* Study staff unable to obtain adequate signal for cerebral blood flow

Where it's running

• Mayo Clinic in Arizona
  Scottsdale, Arizona, United States Recruiting

Study contacts

• Principal investigator: Courtney Wheatley-Guy — Mayo Clinic
• Study coordinator: Jordan Parks
• Email: parks.jordan@mayo.edu
• Phone: 480-301-6616

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

  This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

  Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

• Fatigue Investigation Using Digital Outcomes

  This study tests whether digital monitoring with a smartphone app and wearables can track fatigue in people with MS or long COVID, compared with healthy volunteers.

  Recruiting at 6 sites University of Zurich · Basel, Basel and 5 other locations · NCT07783074

• Biomarker study to understand Long COVID using VIPER

  This study tests biomarkers in people with Long COVID and those who recovered from COVID-19 to see how they can diagnose and track the condition over time.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07770022

• PERCEIVE-Outreach: A scalable care model to help people with Long COVID manage heart and lung symptoms

  This study tests a remote care model to see if a personalized, telehealth-based exercise program helps adults with Long COVID feel better and move more.

  Recruiting University of Tasmania · Hobart, Tasmania and 1 other locations · NCT07661862

• Testing PNMR plus standard care for long COVID

  We’re trying PNMR along with standard care to see if it helps people with long COVID better than standard care alone.

  Recruiting at 4 sites Phase 2 ParagonClinicals Inc. · Brampton, Ontario and 3 other locations · NCT07627815

• Combination therapy for Long COVID symptoms using valacyclovir, celecoxib, and Paxlovid

  This study tests whether a three-drug combination can reduce Long COVID symptoms in adults compared with a placebo.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07597902

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.