Condition

Chronic Fatigue Syndrome clinical trials and research

• 10Clinical trials
• 10NIH research projects
• 5Countries

Newest Chronic Fatigue Syndrome clinical trials

All recruiting trials (10)

• Hyperbaric Oxygen Therapy for ME/CFS

  This study tests whether hyperbaric oxygen therapy can help people with mild to moderate ME/CFS.

  Recruiting Assaf-Harofeh Medical Center · Zrifin · NCT07621068

• Remote Voice Analysis Tool to Help Diagnose and Monitor ME/CFS

  A voice-based tool is tested to help diagnose and manage myalgic encephalomyelitis/chronic fatigue syndrome in people who have the condition.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07551999

• Hydrogen water to reduce fatigue and improve function in ME/CFS

  This project will try hydrogen water in adults with ME/CFS to see if it reduces fatigue and improves function and whether heart rate variability can predict who benefits.

  Recruiting Stony Brook University · Stony Brook, New York · NCT07009691

• Using Lumbrokinase to treat Long Covid, Lyme Disease, and Chronic Fatigue Syndrome

  This study is testing if a treatment called Lumbrokinase can help adults with Long Covid, Lyme Disease, and Chronic Fatigue Syndrome feel better and improve their quality of life.

  Recruiting Phase 1/2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT06511050

• Using vagus nerve stimulation with exercise to help chronic fatigue

  This study is testing if using a special nerve stimulation along with a tailored exercise program can help people with chronic fatigue from fibromyalgia or long Covid feel better and recover faster.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06170645

• A study using wearable devices to manage Long COVID symptoms

  This study is testing if using wearable devices can help people with Long COVID manage their symptoms and improve their quality of life.

  Recruiting Scripps Translational Science Institute · La Jolla, California · NCT05741112

• Monitoring fatigue in breast cancer survivors

  This study is testing how fatigue affects breast cancer survivors by using smart watches and apps to track their daily activities and energy levels after treatment.

  Recruiting Helse Stavanger HF · Stavanger · NCT05587777

• Internet-based treatment for severe functional somatic disorders

  This study is testing a new online therapy program to see if it helps people with severe functional somatic disorders feel better compared to a different online program.

  Recruiting University of Aarhus · Aarhus C, Denmark · NCT05525598

• A 3-day course for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

  This study is testing if a 3-day program called the Lightning Process can help adults with Chronic Fatigue Syndrome feel better and improve their daily lives.

  Recruiting Norwegian University of Science and Technology · Trondheim · NCT05236465

• Measuring brain inflammation in chronic pain and fatigue conditions

  This study is testing a new imaging method to see if people with chronic pain and fatigue, like fibromyalgia and multiple sclerosis, have more brain inflammation compared to healthy individuals.

  Recruiting Phase 1 University of Alabama at Birmingham · Birmingham, Alabama · NCT03759522

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Human Herpesvirus 6B and ME/CFS: does the virus cause or follow immune problems?

  A study to see if HHV-6B reactivation is a cause or result of immune problems in people with ME/CFS, using long-term follow-up and biosamples from patients and controls.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11403869

• Long COVID as a possible subtype of chronic fatigue syndrome

  A study at a major hospital will look at whether Long COVID shares biology with chronic fatigue syndrome and what genetic and immune factors may link them.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11391125

• Is Long COVID a subtype of chronic fatigue syndrome?

  This project looks at whether people with Long COVID share the same genetic and immune signs as people with chronic fatigue syndrome by analyzing large collections of patient data.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11381943

• HHV-6B (a common herpesvirus) and its link to ME/CFS and Long COVID

  This project will follow adults with ME/CFS, some with Long COVID, and healthy controls over time to find out whether reactivation of herpesvirus HHV-6B is linked to changes in symptoms and immune responses.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-11159442

• Long COVID may be a form of chronic fatigue syndrome

  This project looks for shared genetic and immune causes in people with Long COVID and people with chronic fatigue syndrome to explain lingering symptoms.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11143218

• Investigating T Cell Responses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  This study is looking at how a type of immune cell called T cells behaves in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) compared to healthy individuals, to help uncover clues about the condition and find better ways to treat it.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11044125

• Investigating muscle cells to improve diagnosis of chronic fatigue syndrome

  This study is looking at muscle cells from people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to find out how they differ from those of healthy individuals, with the hope of discovering new ways to diagnose and better understand the condition, especially for those who developed symptoms after COVID

  NIH research Lehigh University · Bethlehem, United States · NIH-10951972

• Investigating Long COVID as a type of chronic fatigue syndrome

  This study is looking into how Long COVID works and what might make some people more likely to experience it, especially since it has symptoms similar to chronic fatigue syndrome, to help find better treatments for those who are struggling with these ongoing issues.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10903937

• Investigating the role of Human Herpesvirus 6B in Chronic Fatigue Syndrome

  This study is looking at how a virus called Human Herpesvirus 6B might be linked to the symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) by collecting blood and saliva samples from people with ME/CFS, Long COVID, and healthy individuals to see how the virus affects the immune system over time.

  NIH research London Sch/hygiene & Tropical Medicine · London, United Kingdom · NIH-10903798

• Exploring N-Acetylcysteine as a treatment for chronic fatigue syndrome

  This study is looking at whether a supplement called N-acetylcysteine (NAC) can help people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) feel better by boosting a natural antioxidant in the body, and participants will either get NAC or a placebo to see how it affects their fatigue and overall health

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10821379

Related topics

Quick answers

How many Chronic Fatigue Syndrome clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (5 trials), Norway (2 trials), Denmark (1 trial), Israel (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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