Understanding how neutrophils affect Long COVID in children
Defining neutrophil pathobiology in pediatric Long COVID
This study is looking at how a type of white blood cell called neutrophils behaves in children with Long COVID, to help find better ways to diagnose and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11077808 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in children suffering from Long COVID after SARS-CoV-2 infection. The team will analyze neutrophil activation profiles using advanced techniques like single-cell RNA sequencing and microfluidics to compare children with Long COVID to healthy peers. By identifying specific neutrophil behaviors and gene expressions, the research aims to uncover potential diagnostic and therapeutic strategies for this condition. Additionally, the study will collaborate with an ongoing clinical trial to explore treatments that may reverse harmful neutrophil activation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have experienced Long COVID symptoms following a SARS-CoV-2 infection.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for children suffering from Long COVID.
How similar studies have performed: Previous research has shown that understanding immune cell behavior can lead to significant advancements in treating post-viral syndromes, suggesting potential success for this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yonker, Lael — Massachusetts General Hospital
- Study coordinator: Yonker, Lael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.