Biomarker study to understand Long COVID using VIPER

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify and validate biological markers of Long COVID by collecting health data and biological samples from participants. It leverages the UCSF VIPER program to establish a central, standardized biospecimen resource for cross-lab comparisons. Participants may provide blood, saliva, stool, and, for some, tissue biopsies, to support assay development and longitudinal analyses. The study targets adults with Long COVID or with prior SARS-CoV-2 exposure who have recovered, to better understand disease biology and advance diagnostic tools.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willing and able to provide written informed consent, and
* Age \>/= 18 years, and
* Either:

History of a SARS-CoV-2 infection resulting in Long COVID symptoms, confirmed by the investigator, or

Exposure to SARS-CoV-2 without establishment of Long COVID.

* Enrolled or willing to enroll and complete at least 1 visit in the UCSF Long-term Impact of Infection with Novel Coronavirus (LIINC).
* Enrolled or willing to be referred for a gut biopsy procedure under related IRB-approved protocols.

Exclusion Criteria:

* Self-reported or documented chronic anemia with hemoglobin \< 9 g/dL. Anemia during a preceding acute illness will not be exclusionary.
* Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent.
* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.

Where it's running

• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Study coordinator: VIPER Study UCSF
• Email: VIPERStudy@ucsf.edu
• Phone: (415) 502-2449

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.