Effects of Osteopathic Manipulative Therapy on Long COVID symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of Osteopathic Manipulative Therapy (OMT) on individuals suffering from Long COVID, specifically focusing on whether OMT can alleviate various symptoms beyond olfactory dysfunction. Participants will complete digital surveys regarding their symptoms over an 8-week period, receiving either OMT or a placebo treatment. The study aims to determine if multiple OMT sessions yield greater improvements compared to a single session. The research builds on previous pilot data that indicated OMT may improve smell in Long COVID patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Individuals must claim they have had a prior positive SARS-CoV-2 test at least 6-weeks before the consenting process to proceed with the study
* Individuals must claim they have at least one of the following symptoms greater than 6-weeks post infection that is affecting their daily life(these symptoms correlate with the SBQ™-LC):

Symptoms of Long Covid Inclusion Criteria:

* Shortness of breath or Difficulty Breathing
* Difficulty with Movement (balance or tremor)
* Muscle Pain or stiffness
* Changes in sexual desire
* Worsening Generalized Pain
* Difficulty with Sleep
* Changes in Mood (anxiety or depression)
* Changes in Erectile function (Biological males only)
* Palpations (irregular heart beats)
* Altered Taste
* Changes in your Hair
* Changes in urination
* Dizziness
* Altered Smell
* Changes in Skin
* Changes in bowels
* Fatigue
* Indigestion
* Dry or irritated eyes
* Changes in sweating
* Difficulty with Cognition (memory or thinking)
* Stomach Pain
* Changes in menstruation (Biological females only)
* Chills or shivering

Exclusion Criteria:

* If anyone denies they have any of the above symptoms before consent, they will be excluded from the trial

  * They will also be excluded from the trial if they have suffered any fractured bones in the last 3 months (this will further decrease risk to the patient as the patient will be moved by the physician during the treatment protocol)
  * Participants who are enrolled in other Long-COVID trials that have an intervention during their participation in this trial will be excluded. However, if they have a history of enrollment in a long-covid trial that has no interventions during this trial, they will not be excluded based on their history of acquiring experimental treatment.

Where it's running

• University of Louisville Outpatient Care Center
  Louisville, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Darryl Kaelin, MD, Medical Doctorate (US) — University of Louisville School of Medicine Chair of PM&R Division of the Department of Neurological Surgery
• Study coordinator: Michael E Stenta, DO, Doctor of Osteopathic Medicine
• Email: michael.stenta@uoflhealth.org
• Phone: 15137289344

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Magnetic resonance and rapid brain stimulation for Long COVID cognitive and mood symptoms

  This trial will test whether an accelerated outpatient magnetic brain stimulation (iTBS) can help reduce brain fog, depression, and anxiety in adults with Long COVID.

  Recruiting Phase 2 University of New Mexico · Albuquerque, New Mexico · NCT06940609

• Immunoadsorption blood filter for autoimmune long COVID

  We will test a blood-filter treatment called immunoadsorption in people with long COVID who have specific autoantibodies to see if their fatigue and daily functioning get better.

  Recruiting Phase 2 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07316127

• Anktiva for treating Long COVID symptoms

  This will test whether Anktiva helps adults aged 18–69 who had confirmed COVID-19 and now have persistent or worsened Long COVID symptoms.

  Recruiting Phase 2 ImmunityBio, Inc. · El Segundo, California · NCT07123727

• Analyzing MicroRNAs and Vitamin B12 in Long COVID Patients with Neurological Symptoms

  This study is testing if changes in certain microRNAs and vitamin B12 levels in the blood can help understand and treat neurological symptoms like depression and fatigue in people who have long COVID.

  Recruiting Instituto Nacional de Rehabilitacion · Mexico City, Mexico City · NCT06864156

• Improving life for patients with chronic fatigue syndrome

  This study is testing if two medications can help people aged 18-65 with chronic fatigue syndrome feel better and manage their symptoms.

  Recruiting Phase 2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06366724

• Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

  This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

  Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.