Observational study on post-COVID-19 complications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to evaluate the short- and long-term end-organ complications associated with COVID-19 in individuals aged 18 to 100 years. It will recruit up to 627 participants, including those with asymptomatic, mild, moderate, or severe COVID-19 infections, and will follow them for 24 months after symptom onset or diagnosis. The study will also establish a biobank for future research and develop predictive models for end-organ complications. Primary endpoints include the development of any end-organ complications plausibly related to COVID-19.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any gender, ≥ 18 years old
* Current resident of Quebec
* Speaks English or French
* Have a personal email (to which to send reminders and questionnaire by email )

AND

1 of the following criteria:

• Individuals with at least one COVID-19 positive PCR test, serology or antibody/antigen test in the last 60 months at day of recruitment. In the absence of a positive COVID-19 test, individuals with symptoms consistent with COVID-19 while living with a person who had a confirmed positive PCR, serology or antibody/antigen COVID-19 test in the last 60 months at day of recruitment (epidemiologic link).

OR

• Individuals who tested negative for COVID-19 while living with a household member who tested positive for COVID-19 or had a close contact with the viral infection in the context of their work, and never had any COVID-19 related symptoms (presumed COVID negative control group).

OR

• Individuals who don't have any COVID-19 related symptoms actually, have never had tested positive, and have had at least one negative PCR, serology or antibody/antigen COVID-19 test (presumed COVID negative control group).

OR

• Individuals with an undiagnosed viral infection in the last 60 months at day of recruitment and have persistent symptoms (or not) after the participant has recovered from a viral infection.

Exclusion Criteria:

* Any participant not deemed appropriate for enrollment according to the PI
* Known pregnancy (female will not be automatically screened for pregnancy upon enrollment unless there is a possibility that they might be pregnant)

Where it's running

• Institut de Recherches Cliniques de Montreal
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Emilia Liana Falcone, M.D., Ph.D. — Ircm
• Study coordinator: Emilia Liana Falcone, M.D., Ph.D.
• Email: Emilia.falcone@ircm.qc.ca
• Phone: 514-987-5610

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

  This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

  Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

• Fatigue Investigation Using Digital Outcomes

  This study tests whether digital monitoring with a smartphone app and wearables can track fatigue in people with MS or long COVID, compared with healthy volunteers.

  Recruiting at 6 sites University of Zurich · Basel, Basel and 5 other locations · NCT07783074

• Biomarker study to understand Long COVID using VIPER

  This study tests biomarkers in people with Long COVID and those who recovered from COVID-19 to see how they can diagnose and track the condition over time.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07770022

• PERCEIVE-Outreach: A scalable care model to help people with Long COVID manage heart and lung symptoms

  This study tests a remote care model to see if a personalized, telehealth-based exercise program helps adults with Long COVID feel better and move more.

  Recruiting University of Tasmania · Hobart, Tasmania and 1 other locations · NCT07661862

• Testing PNMR plus standard care for long COVID

  We’re trying PNMR along with standard care to see if it helps people with long COVID better than standard care alone.

  Recruiting at 4 sites Phase 2 ParagonClinicals Inc. · Brampton, Ontario and 3 other locations · NCT07627815

• Combination therapy for Long COVID symptoms using valacyclovir, celecoxib, and Paxlovid

  This study tests whether a three-drug combination can reduce Long COVID symptoms in adults compared with a placebo.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07597902

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.