Clinical trial Recruiting at 1 site Observational Ages 18 to 65

Analyzing MicroRNAs and Vitamin B12 in Long COVID Patients with Neurological Symptoms

Official title: Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19

Run by Instituto Nacional de Rehabilitacion · NCT06864156 · Data updated 2026-11-12

This study is testing if changes in certain microRNAs and vitamin B12 levels in the blood can help understand and treat neurological symptoms like depression and fatigue in people who have long COVID.

More Long COVID trials

Quick facts

Study typeObservational
Ages18 Years to 65 Years
SexAll
Enrollment20 (estimated)
SponsorInstituto Nacional de Rehabilitacion
Government
Locations1 site (Mexico City, Mexico City)
StatusRecruiting
StartedFebruary 18, 2025
Main results expectedJuly 2025
Study endsJuly 2025
Registry record updatedMarch 7, 2025
Trial IDNCT06864156 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with a confirmed COVID-19 diagnosis who are experiencing neurological symptoms of depression, anxiety, and fatigue at least three months post-infection.

Probably not a fit

Patients who have had recent acute COVID-19 symptoms or pre-existing neurological conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the expression of specific microRNAs and vitamin B12 levels in individuals experiencing neurological symptoms such as depression, anxiety, and fatigue following COVID-19 infection. By analyzing blood samples from these patients, the research aims to identify changes in biological processes that occur post-infection. The ultimate goal is to enhance diagnostic methods and develop targeted therapies for long COVID symptoms. The study focuses on patients who have had confirmed COVID-19 and exhibit these neurological symptoms three months after their acute infection.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnostic tools and therapies for patients suffering from long COVID-related neurological symptoms.

How similar studies have gone: While the specific approach of analyzing microRNAs and vitamin B12 in long COVID is relatively novel, similar studies have explored biomarkers in post-viral syndromes with varying degrees of success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR or antigen testing.
* With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 after three months from the first day of acute infection symptoms.

Exclusion Criteria:

* Subjects who have presented symptoms of acute infection in the last twelve weeks.
* Subjects who present diagnostic premorbid neurological alterations.
* Subjects who do not have at least 2 doses of COVID-19 vaccine, with last application date equal or older than 3 months.

Where it's running

  • Instituto Nacional de Rehabilitación
    Mexico City, Mexico City, Mexico
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Immunoadsorption blood filter for autoimmune long COVID

    We will test a blood-filter treatment called immunoadsorption in people with long COVID who have specific autoantibodies to see if their fatigue and daily functioning get better.

    Recruiting Phase 2 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07316127

  • Anktiva for treating Long COVID symptoms

    This will test whether Anktiva helps adults aged 18–69 who had confirmed COVID-19 and now have persistent or worsened Long COVID symptoms.

    Recruiting Phase 2 ImmunityBio, Inc. · El Segundo, California · NCT07123727

  • Magnetic resonance and rapid brain stimulation for Long COVID cognitive and mood symptoms

    This trial will test whether an accelerated outpatient magnetic brain stimulation (iTBS) can help reduce brain fog, depression, and anxiety in adults with Long COVID.

    Recruiting Phase 2 University of New Mexico · Albuquerque, New Mexico · NCT06940609

  • Effects of Osteopathic Manipulative Therapy on Long COVID symptoms

    This study is testing whether Osteopathic Manipulative Therapy can help people with Long COVID feel better by reducing their symptoms over eight weeks.

    Recruiting University of Louisville · Louisville, Kentucky · NCT06883513

  • Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID

    This study tests whether brief, repeated exposure to extreme cold can help reduce fatigue and related symptoms in adults with ME/CFS, fibromyalgia, or Long COVID compared to healthy controls.

    Recruiting Oxford Brookes University · Oxford, Oxon · NCT07874217

  • Fatigue Investigation Using Digital Outcomes

    This study tests whether digital monitoring with a smartphone app and wearables can track fatigue in people with MS or long COVID, compared with healthy volunteers.

    Recruiting at 6 sites University of Zurich · Basel, Basel and 5 other locations · NCT07783074

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.