Analyzing MicroRNAs and Vitamin B12 in Long COVID Patients with Neurological Symptoms
Official title: Evaluation of MicroRNAs and Vitamin B12 Expression in Subjects with Neurologic Symptoms of Depression, Anxiety and Fatigue in Long COVID-19
Run by Instituto Nacional de Rehabilitacion · NCT06864156 · Data updated 2026-11-12
This study is testing if changes in certain microRNAs and vitamin B12 levels in the blood can help understand and treat neurological symptoms like depression and fatigue in people who have long COVID.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Instituto Nacional de Rehabilitacion Government |
| Locations | 1 site (Mexico City, Mexico City) |
| Status | Recruiting |
| Started | February 18, 2025 |
| Main results expected | July 2025 |
| Study ends | July 2025 |
| Registry record updated | March 7, 2025 |
| Trial ID | NCT06864156 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a confirmed COVID-19 diagnosis who are experiencing neurological symptoms of depression, anxiety, and fatigue at least three months post-infection.
✕Probably not a fit
Patients who have had recent acute COVID-19 symptoms or pre-existing neurological conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the expression of specific microRNAs and vitamin B12 levels in individuals experiencing neurological symptoms such as depression, anxiety, and fatigue following COVID-19 infection. By analyzing blood samples from these patients, the research aims to identify changes in biological processes that occur post-infection. The ultimate goal is to enhance diagnostic methods and develop targeted therapies for long COVID symptoms. The study focuses on patients who have had confirmed COVID-19 and exhibit these neurological symptoms three months after their acute infection.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapies for patients suffering from long COVID-related neurological symptoms.
How similar studies have gone: While the specific approach of analyzing microRNAs and vitamin B12 in long COVID is relatively novel, similar studies have explored biomarkers in post-viral syndromes with varying degrees of success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects with confirmed diagnosis of COVID-19 by SARS-CoV-2 infection by PCR or antigen testing. * With presence of neurological symptoms of depression, anxiety and fatigue associated with COVID-19 after three months from the first day of acute infection symptoms. Exclusion Criteria: * Subjects who have presented symptoms of acute infection in the last twelve weeks. * Subjects who present diagnostic premorbid neurological alterations. * Subjects who do not have at least 2 doses of COVID-19 vaccine, with last application date equal or older than 3 months.
Where it's running
-
Instituto Nacional de Rehabilitación
Mexico City, Mexico City, Mexico Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Anktiva for treating Long COVID symptoms
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Whole-body Cryotherapy for Fatigue in ME/CFS, Fibromyalgia, Long COVID
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Fatigue Investigation Using Digital Outcomes
This study tests whether digital monitoring with a smartphone app and wearables can track fatigue in people with MS or long COVID, compared with healthy volunteers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.