Treatment for cognitive impairments in long COVID patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a 24-week open trial aimed at evaluating the effects of DAOIB on cognitive impairments in patients suffering from long COVID. Participants will receive DAOIB for the entire duration and will be assessed every 8 weeks to monitor improvements in cognitive function, mood symptoms, global functioning, and quality of life. The study specifically targets individuals who have experienced cognitive issues following COVID-19 infection, ensuring they meet specific health criteria. The goal is to determine the efficacy of DAOIB in alleviating these cognitive challenges.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* "post-COVID-19 condition" defined by WHO (symptoms present at three months after SARS-CoV-2 infection and last for at least 2 months which cannot be explained by an alternative diagnosis)(Cabrera Martimbianco, Pacheco et al. 2021) and COVID-induced cognitive impairments
* physically healthy and have all laboratory assessments (including urine/blood routine, biochemical tests, and electrocardiograph) within normal limits
* have sufficient education to communicate effectively and are capable of completing the assessments of the study

Exclusion Criteria:

* history of significant cerebrovascular disease
* Hachinski Ischemic Score \> 4
* major neurological, psychiatric or medical conditions other than long COVID-induced cognitive impairments
* memantine use (memantine is an NMDAR partial antagonist)
* substance (including alcohol) abuse or dependence
* delusion, hallucination or delirium symptoms
* severe visual or hearing loss
* inability to follow the protocol

Where it's running

• Kaohsiung Chang Gung Memorial Hospital
  Kaohsiung City, Taiwan Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.