Understanding how insulin sensitivity works in muscle cells
Official title: Insulin sensitivity in skeletal muscle
Funded at Saint Louis University · NIH-10439090 · Data updated 2026-11-12
This study is looking at how exercise and muscle activity can help insulin work better to move sugar into muscle cells, which is important for people with diabetes, and they’re doing this by testing different ideas in the lab.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $378,750 |
| NIH project number | 1R15DK132727-01 |
| Project ID | NIH-10439090 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with insulin resistance or type 2 diabetes who may benefit from improved glucose management.
✕Less likely to help
Patients who do not have insulin resistance or diabetes may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms that affect how insulin helps glucose enter muscle cells, which is crucial for managing diabetes. The team will explore how certain proteins and pathways, particularly those activated by exercise and muscle contractions, can enhance insulin sensitivity. By studying these processes in muscle cells, they aim to uncover new ways to improve glucose transport and insulin response. The research involves laboratory experiments using muscle cells to test various hypotheses about insulin signaling.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and glucose control for people with diabetes.
How similar studies have gone: Previous research has shown promising results in enhancing insulin sensitivity through similar mechanisms, indicating potential for success in this approach.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Fisher, Jonathan S. — Saint Louis University
- Study coordinator: Fisher, Jonathan S.
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A study will look at how specific fats circulating in the blood and in tissues relate to blood vessel function and insulin sensitivity in adults who work night shifts.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.