Identifying predictors of weight loss and metabolic health after bariatric surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify preoperative predictors that influence weight loss and metabolic health improvements following bariatric surgery. The research focuses on various factors including inflammation, insulin sensitivity, psychological traits, feeding behaviors, and cardiorespiratory fitness. By understanding these predictors, the study seeks to tailor treatment approaches for individuals undergoing bariatric surgery, thereby optimizing their outcomes. The study will involve patients scheduled for Roux-en-Y gastric bypass or Sleeve Gastrectomy, with a focus on those who are insulin resistant.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to provide informed consent
* Patient is ≥ 18 and ≤ 75 years old
* BMI ≥ 40 kg/m2 or ≥ 35 kg/m2 with obesity related comorbidity
* Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass (RYGB) or Sleeve Gastrectomy (SG)
* Stable weight 3 months prior to inclusion weight (\<10% change in body weight for 3 months prior to assessments)

In order to be eligible to participate in the subgroup of this study, we will use the following inclusion criteria:

* Ability to provide informed consent
* Patient is ≥ 18 and ≤ 75 years old
* BMI ≥ 40 kg/m2 or ≥ 35 kg/m2 with obesity related comorbidity
* Patients scheduled for RYGB
* Patients who are insulin resistant (impaired fasting glucose (\> 5.6 mmol/L) or fasting insulin \> 74 pmol/L)
* Postmenopausal women (to prevent bias due to the effect of sex hormones on insulin sensitivity)

Exclusion Criteria:

* Any actual medical condition except for obesity related health issues or well treated hypothyroidism
* Pregnancy anticipated in the first two years following surgery

A potential subject who meet the following criteria will be excluded from participation in the subgroup of this study:

* Coagulation disorders and/or use anticoagulants
* Use of any medication except for statins, antihypertensives (except for Angiotensine converting enzyme (ACE)- or angiotensin receptor blockers) and thyroid hormone
* Diabetes mellitus type 2

Where it's running

• Nederlandse Obesitas Kliniek Den Haag
  The Hague, South Holland, Netherlands Recruiting
• Nederlandse Obesitas Kliniek Gouda
  Gouda, South Holland, Netherlands Not yet recruiting
• Nederlandse Obesitas Kliniek Nieuwegein
  Nieuwegein, Utrecht, Netherlands Not yet recruiting

Study contacts

• Principal investigator: Mireille JM Serlie, Prof. Dr. — Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Study coordinator: Rieneke van der Meer, Drs.
• Email: r.vandermeer1@amsterdamumc.nl
• Phone: +31703204703

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding genetic factors that affect weight loss after bariatric surgery

  This study is trying to find out if certain genes can help predict how well people with severe obesity will lose weight after having bariatric surgery.

  Recruiting Institut de Recerca Biomèdica de Lleida · Lleida, Leida · NCT06226194

• Understanding why some patients don't lose weight after bariatric surgery

  This study is trying to find out why some people don’t lose as much weight as expected after bariatric surgery, focusing on the role of gut hormones to help improve their results.

  Recruiting Imperial College London · London · NCT05404061

• Survey on bariatric surgery for adolescents

  This study is trying to see how well laparoscopic adjustable gastric banding works for teenagers aged 14-20 who are having bariatric surgery, focusing on weight loss and any health issues that might come up.

  Recruiting University Hospital, Angers · Angers, Maine Et Loire · NCT04766801

• Registry for bariatric surgery quality control

  This study is setting up a registry to track the results and safety of bariatric surgery for people who are severely obese to help improve surgical practices.

  Recruiting Sheba Medical Center · Ramat Gan · NCT04040413

• Long-term follow-up of severely obese patients after bariatric surgery

  This study is trying to see how well different types of weight loss surgery work for severely obese patients over the long term and how it affects their health and quality of life.

  Recruiting University Hospital, Montpellier · Montpellier · NCT02310178

• Glycemic variability after SASI versus Roux-en-Y gastric bypass

  This trial tests whether SASI or Roux-en-Y gastric bypass leads to different glucose fluctuations in adults with severe obesity using continuous glucose monitoring.

  Recruiting Hospitales Universitarios Virgen del Rocío · Seville, Sevilla · NCT07872397

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.