Investigating how exercise affects muscle insulin sensitivity
The Significance of Physical Activity for Insulin Signaling Dynamics and Insulin Sensitivity
NA · University of Copenhagen · NCT06776094
This study tests how a single session of one-legged exercise affects how well young healthy men’s muscles respond to insulin.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 8 (estimated) |
| Ages | 22 Years to 35 Years |
| Sex | Male |
| Sponsor | University of Copenhagen (other) |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT06776094 on ClinicalTrials.gov |
What this trial studies
This study examines the effects of a single bout of one-legged knee-extensor exercise on muscle insulin sensitivity in young healthy males. Participants will undergo a controlled exercise session followed by a hyperinsulinemic-euglycemic clamp to assess insulin signaling dynamics. Blood samples and muscle biopsies will be collected at various time points to analyze changes in insulin sensitivity and glucose uptake mechanisms. The study aims to provide insights into the temporal development of insulin signaling post-exercise.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy young males aged 22-35 with a BMI between 28 and 35 and a moderate fitness level.
Not a fit: Patients who are women, have significant physical activity levels, or any acute illnesses may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how exercise improves insulin sensitivity, potentially leading to better management strategies for insulin resistance.
How similar studies have performed: Other studies have shown promising results regarding the effects of exercise on insulin sensitivity, making this approach both relevant and supported by existing literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy individuals (no known diseases) * No use of medication * Non-smokers * Male * Aged 22-35 years * Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg * BMI between 28 and 35 Exclusion Criteria: * Women * Failure to meet all inclusion criteria * Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week * Acute illness within 2 weeks prior to the study days * Use of recreational drugs within 2 weeks prior to the study days
Where this trial is running
Copenhagen
- University of Copenhagen, August Krogh Section for Human and Molecular Physiology — Copenhagen, Denmark (RECRUITING)
Study contacts
- Principal investigator: Jørgen FP Wojtaszewski, Prodessor — Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark
- Study coordinator: Jørgen FP Wojtaszewski, Professor
- Email: jw@nexs.ku.dk
- Phone: +4535321625
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Insulin Sensitivity, Exercise, Muscle insulin sensitivity, Muscle glucose uptake, GLUT4, Phosphoproteomics