Investigating how exercise affects muscle insulin sensitivity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the effects of a single bout of one-legged knee-extensor exercise on muscle insulin sensitivity in young healthy males. Participants will undergo a controlled exercise session followed by a hyperinsulinemic-euglycemic clamp to assess insulin signaling dynamics. Blood samples and muscle biopsies will be collected at various time points to analyze changes in insulin sensitivity and glucose uptake mechanisms. The study aims to provide insights into the temporal development of insulin signaling post-exercise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy individuals (no known diseases)
* No use of medication
* Non-smokers
* Male
* Aged 22-35 years
* Fitness level (VO2max, i.e., maximal oxygen uptake) between 30-50 mL O2/min/kg
* BMI between 28 and 35

Exclusion Criteria:

* Women
* Failure to meet all inclusion criteria
* Physical activity level (e.g., running, cycling, fitness, etc.) exceeding 6 hours per week
* Acute illness within 2 weeks prior to the study days
* Use of recreational drugs within 2 weeks prior to the study days

Where it's running

• University of Copenhagen, August Krogh Section for Human and Molecular Physiology
  Copenhagen, Denmark Recruiting

Study contacts

• Principal investigator: Jørgen FP Wojtaszewski, Prodessor — Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark
• Study coordinator: Jørgen FP Wojtaszewski, Professor
• Email: jw@nexs.ku.dk
• Phone: +4535321625

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Improve Teen Sleep to Support Healthy Blood Sugar and Metabolism

  This study tests whether extending and timing teens’ sleep, with melatonin and morning light, can improve insulin sensitivity and energy use in overweight adolescents.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07618117

• Weekly physiologic insulin sessions to improve insulin sensitivity and memory in Alzheimer’s

  This trial will test whether weekly short (up to two-hour) physiologic insulin sessions can improve how the body uses glucose and help thinking and memory in adults with Alzheimer’s disease.

  Recruiting Pennington Biomedical Research Center · Baton Rouge, Louisiana · NCT07265323

• Colchicine to improve insulin sensitivity in people with type 1 diabetes and low-grade inflammation

  This trial will test whether adding colchicine to usual care can improve insulin sensitivity in adults with type 1 diabetes who have chronic low-grade inflammation.

  Recruiting Phase 2 University Hospital, Gentofte, Copenhagen · Gentofte Municipality · NCT07247734

• Understanding how different meals affect metabolism

  This study tests how different types of meals affect metabolism in young adults to see how their bodies respond to various nutrients.

  Recruiting Instituto Nacional de Medicina Genomica · Mexico City · NCT06878781

• Effects of Lipids on Health in Night Shift Workers

  This study is testing how certain fats in the body affect heart health and blood sugar in people who work night shifts, while also trying a new eating schedule to see if it helps.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT06550115

• Investigating the impact of a GLP-1 medication on brain insulin response

  This study is testing if a medication called semaglutide can change how the brain responds to insulin in people of different weights to see if it helps with thinking and eating habits.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06487832

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.