Improving insulin sensitivity in people living with HIV through nutrition in Oklahoma
Official title: Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NOURISH OK)
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10906104 · Data updated 2026-11-12
The NOURISH OK project is looking at how what you eat can impact insulin sensitivity for people living with HIV, especially those from low-income backgrounds, and it aims to find ways to improve health by understanding the connection between food access and health challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 17, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $472,235 |
| NIH project number | 5R01DK127464-05 |
| Project ID | NIH-10906104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are low-income individuals living with HIV in Oklahoma, particularly those experiencing food insecurity.
✕Less likely to help
Patients who are not living with HIV or those who do not face food insecurity may not benefit from this research.
What this research studies
The NOURISH OK project investigates how nutrition affects insulin sensitivity in individuals living with HIV, particularly focusing on those from low-income backgrounds. By engaging with communities, the research aims to understand the links between food insecurity and insulin resistance, using surveys and observational studies to gather data. The study will explore dietary habits and other biological factors that may contribute to health disparities among HIV-positive individuals. Participants will be involved in identifying effective interventions to improve their health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and interventions that enhance insulin sensitivity and overall health for people living with HIV.
How similar studies have gone: Previous research has shown promising results in addressing health disparities through community-based interventions, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Wetherill, Marianna — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Wetherill, Marianna
Related research
Other NIH-funded projects on the same topics.
-
How clock-watching lifestyle affects fats, blood vessels, and insulin in night-shift workers
This study looks at how being awake and active at night changes lipids in the blood and muscle and what that means for blood vessel function and insulin in adults who work night shifts.
-
How bile acids affect insulin and metabolism in humans
A study using humanized mouse models and human cell systems will explore how a specific group of bile acids (12HBAs) influence insulin signaling and metabolic health in adults.
-
Placental miRNAs and insulin sensitivity in pregnancy
This grant explores whether tiny molecules from the placenta help control how the mother’s body handles insulin during pregnancy, with potential implications for gestational diabetes.
-
Understanding how fat tissue changes affect insulin health
This grant supports a clinician-scientist to explore how fat tissue in adults with obesity influences insulin sensitivity using human data and advanced analyses.
-
Regulation of a new adipokine that improves insulin sensitivity
A scientist-led study will explore how a newly found adipokine called NRN1 helps fat tissue control insulin and glucose in adults with obesity and type 2 diabetes.
-
Understanding how lipids affect blood vessels and insulin in night-shift workers
A study will look at how specific fats circulating in the blood and in tissues relate to blood vessel function and insulin sensitivity in adults who work night shifts.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.