Investigating how insulin sensitivity affects metformin's ability to slow aging
Official title: Does insulin sensitivity impact the potential of metformin to slow aging?
Funded at Oklahoma Medical Research Foundation · NIH-10791774 · Data updated 2026-11-12
This study is looking at whether metformin, a medication usually used for diabetes, can help people stay healthier for longer as they age, especially focusing on how insulin sensitivity might affect its benefits for those without chronic diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2019 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $565,721 |
| NIH project number | 5R01AG064951-05 |
| Project ID | NIH-10791774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are free of chronic diseases and have varying levels of insulin sensitivity.
✕Less likely to help
Patients with existing chronic diseases or those who are not insulin sensitive may not benefit from this research.
What this research studies
This research explores the potential of metformin, a common diabetes medication, to delay aging and extend healthy lifespan. It focuses on understanding how insulin sensitivity may influence the effectiveness of metformin in individuals who are free of chronic diseases. By analyzing data from previous clinical trials, the study aims to identify which patients might benefit from metformin treatment and whether it could have negative effects on metabolic health. The research will involve human studies to clarify these relationships and guide future clinical trials.
Why it matters
Potential benefit: If successful, this research could help identify which patients can safely use metformin to potentially slow aging and improve overall health.
How similar studies have gone: Previous research has shown mixed results regarding metformin's effects on aging, indicating that this area is still being explored and holds potential for new insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Miller, Benjamin Francis — Oklahoma Medical Research Foundation
- Study coordinator: Miller, Benjamin Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.