Investigating how glucocorticoid receptors affect insulin sensitivity
Official title: Glucocorticoid Receptor Coregulators and Insulin Sensitivity
Funded at University of California Berkeley · NIH-10746410 · Data updated 2026-11-12
This study is looking at how a specific protein called Ehmt2 affects insulin sensitivity, especially when the body is exposed to high levels of certain hormones over time, which could help us find better ways to manage insulin resistance in people with type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | December 10, 2020 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $381,608 |
| NIH project number | 5R01DK124866-04 |
| Project ID | NIH-10746410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes or those experiencing insulin resistance.
✕Less likely to help
Patients without insulin resistance or those with type 1 diabetes may not benefit from this research.
What this research studies
This research explores the role of glucocorticoid receptors and their coregulators in insulin sensitivity, particularly focusing on the effects of chronic glucocorticoid exposure. The study aims to understand how the coregulator Ehmt2 influences insulin resistance through its dual functions as a coactivator and corepressor. By using advanced techniques like RNA sequencing and hyperinsulinemic-euglycemic clamps, researchers will assess how changes in Ehmt2 affect glucose metabolism in the liver and overall insulin signaling. This could lead to new insights into managing insulin resistance in patients with type 2 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving insulin sensitivity in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding glucocorticoid effects on metabolism, indicating that this approach has potential for success.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Wang, Jen-Chywan — University of California Berkeley
- Study coordinator: Wang, Jen-Chywan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.