Investigating how glucocorticoid receptors affect insulin sensitivity
Glucocorticoid Receptor Coregulators and Insulin Sensitivity
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10746410
This study is looking at how a specific protein called Ehmt2 affects insulin sensitivity, especially when the body is exposed to high levels of certain hormones over time, which could help us find better ways to manage insulin resistance in people with type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10746410 on ClinicalTrials.gov |
What this research studies
This research explores the role of glucocorticoid receptors and their coregulators in insulin sensitivity, particularly focusing on the effects of chronic glucocorticoid exposure. The study aims to understand how the coregulator Ehmt2 influences insulin resistance through its dual functions as a coactivator and corepressor. By using advanced techniques like RNA sequencing and hyperinsulinemic-euglycemic clamps, researchers will assess how changes in Ehmt2 affect glucose metabolism in the liver and overall insulin signaling. This could lead to new insights into managing insulin resistance in patients with type 2 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes or those experiencing insulin resistance.
Not a fit: Patients without insulin resistance or those with type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving insulin sensitivity in patients with type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding glucocorticoid effects on metabolism, indicating that this approach has potential for success.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, JEN-CHYWAN — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: WANG, JEN-CHYWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Ketosis-Resistant Diabetes Mellitus, Maturity-Onset Diabetes Mellitus, Non-Insulin Dependent Diabetes, Noninsulin Dependent Diabetes