Investigating the effects of metformin and automated insulin delivery on kidney and heart health in youth with Type 1 Diabetes

Who could benefit from this research

What this research studies

This research explores how metformin, a medication commonly used for diabetes, combined with automated insulin delivery systems, can improve kidney function and heart health in young people with Type 1 Diabetes. The study involves a randomized trial where participants aged 12-21 will receive either metformin or a placebo while using an automated insulin delivery system. Researchers will measure changes in insulin sensitivity and renal vascular resistance to understand the potential benefits of this combined approach. The goal is to find effective strategies to reduce the risk of kidney and cardiovascular diseases in youth with diabetes.

Why it matters

Where this research is happening

• Seattle Children's Hospital
  Seattle, United States Active

Researchers

• Principal investigator: Tommerdahl, Kalie L — Seattle Children's Hospital
• Study coordinator: Tommerdahl, Kalie L

Related research

Other NIH-funded projects on the same topics.

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• Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology

  This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603068

• Helping people with type 1 diabetes regain awareness of dangerous lows

  A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.

  NIH research University of Sheffield · Sheffield, United Kingdom · NIH-11603067

• How the pancreas environment affects insulin-producing cells in type 1 diabetes

  Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.

  NIH research Colorado School of Mines · Golden, United States · NIH-11592249

• Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it

  This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11582458

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.