Effects of tirzepatide and bimagrumab on body fat, insulin sensitivity, and bone health in adults with obesity

Who could benefit from this research

What this research studies

If you have obesity, losing fat—especially visceral fat—can improve your heart and metabolic health, but losing too much lean muscle or bone can be risky. This research tests how tirzepatide combined with bimagrumab may help you lose fat while preserving muscle and bone, potentially improving insulin sensitivity. Participants would undergo treatments and assessments to measure body composition, bone density, and metabolic responses over time. The goal is to identify a weight-loss approach that benefits fat, muscle, and bone together in adults with obesity.

Why it matters

Where this research is happening

• Massachusetts General Hospital
  Boston, United States Active

Researchers

• Principal investigator: Haines, Melanie Schorr — Massachusetts General Hospital
• Study coordinator: Haines, Melanie Schorr

Related research

Other NIH-funded projects on the same topics.

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  This study is looking at how a new drug called bimagrumab can help adults with obesity lose fat while keeping their muscles and bones healthy, and it will also include some lifestyle changes to help with weight loss.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10898713

• How obesity drugs and exercise affect muscle and body fat in adults with obesity and diabetes

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  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11416732

• Advancing Aging, Obesity, and Body Composition Care

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  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11350614

• Using medication to help adolescents with obesity and type 2 diabetes lose weight and improve health.

  This study is looking at how well a medication called liraglutide can help teenagers with obesity and type 2 diabetes lose weight and improve their blood sugar control, with the hope of keeping them healthier in the long run.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11099717

• Investigating body composition and its effects on kidney cancer outcomes

  This study is looking at how different aspects of body composition, not just weight, can impact survival for people with clear cell kidney cancer, using CT scans and tumor samples to find helpful insights for better health recommendations.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10675702

• Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis

  This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11644470

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.