Investigating how exercise affects insulin sensitivity through mTOR
Official title: Mechanistic Target of Rapamycin (mTOR) as Mediator of Exercise-induced Insulin Sensitivity Study
Run by University of Copenhagen · NCT05233722 · Data updated 2026-11-12
This study is testing if a medication that blocks a specific pathway in the body can change how exercise helps young healthy men improve their insulin sensitivity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 22 Years to 35 Years |
| Sex | Men only |
| Enrollment | 10 (estimated) |
| Sponsor | University of Copenhagen Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | February 10, 2022 |
| Main results expected | June 2029 |
| Study ends | June 2029 |
| Registry record updated | May 16, 2024 |
| Trial ID | NCT05233722 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy young men aged 22-35 with a BMI between 18.0 and 25.0 who engage in moderate physical activity.
✕Probably not a fit
Patients who are women, highly active individuals, or those with metabolic diseases will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines the role of the mTOR pathway in enhancing muscle insulin sensitivity after exercise in young healthy males. Participants will undergo a controlled exercise regimen while receiving either a pharmacological mTOR inhibitor, Rapamycin, or a placebo. The study employs a crossover design, allowing each participant to serve as their own control, with various blood sampling and infusion protocols to measure muscle glucose uptake and protein synthesis. The goal is to understand the biochemical mechanisms that improve insulin sensitivity through exercise.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for improving insulin sensitivity, which is crucial for preventing metabolic diseases.
How similar studies have gone: While the specific approach of using mTOR inhibition in this context is novel, related studies have shown promising results in understanding the role of exercise in insulin sensitivity.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy persons (no known disease) without diabetes in the family * No use of medications * Non-smokers * Men * Age 22-35 years * Physical activity level (VO2peak) between 30-50 mL O2/min/kg * BMI between 18.0 and 25.0 Exclusion Criteria: * Women * Physical activity (e.g., running, cycling, fitness, etc.) above 6 hours a week. * Persons who show signs of metabolic diseases, hematologic diseases, reduced liver function, human immunodeficiency virus (HIV), hepatitis, thyroid diseases or other signs of disease that may affect the outcome of the study or the study subject's wellbeing will be excluded. * Acute sickness less than 2 weeks prior to study start. * If disease appears or is identified and/or a need for medication arises after inclusion but before initiation of the study. Disease during conclusion of the study
Where it's running
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University of Copenhagen
Copenhagen, Denmark Recruiting
Study contacts
- Principal investigator: Jørgen FP Wojtaszewski, Professor — Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark
- Study coordinator: Jørgen FP Wojtaszewski, Professor
- Email: jw@nexs.ku.dk
- Phone: +4535321625
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.