Condition

Overweight and Obesity clinical trials and research

• 63Clinical trials
• 7NIH research projects
• 21Countries

Newest Overweight and Obesity clinical trials

All recruiting trials (63)

• Nutrition support to improve dietary diversity in adults who are underweight or overweight/obese

  A community-based nutrition program will be tested in adults in Cambodia to see if it improves dietary diversity and if the program is acceptable and feasible to run.

  Recruiting National University of Singapore · Phnom Penh, Phnom Penh · NCT07836322

• Hesperidin for better thinking in overweight older adults

  In adults aged 55–75 who are overweight, taking hesperidin or a placebo for 10 weeks will show whether the citrus flavonoid can improve thinking skills like memory, attention, and problem-solving.

  Recruiting University of Glasgow · Shanghai, Shanghai Municipality · NCT07750223

• MR-based performance tests for overweight and obesity

  This study tests mixed reality versions of mobility tests to see if they match conventional assessments in adults who are overweight or obese.

  Recruiting Selcuk University · Konya, Selcuklu · NCT07654439

• DA-302168S in adults with overweight or obesity

  A phase 3 trial in China is testing whether DA-302168S helps people who are overweight or obese lose weight compared with a placebo.

  Recruiting Phase 3 Chendu DIAO Pharmaceutical Group CO., LTD. · Beijing · NCT07629544

• Metabolic Health Trajectories in Overweight Chinese Adults

  This observational study follows overweight and obese Chinese adults to see how metabolic health changes over five years and whether people stay healthy, develop diabetes, or have complications.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT07584330

• Blood-count inflammation scores (SII and SIRI) to predict metabolic complications in adults with overweight or obesity

  This project will test whether two blood-count-based scores (SII and SIRI) can help predict metabolic complications and treatment response in adults with overweight or obesity.

  Recruiting University of Rijeka · Varaždin · NCT07431593

• 4-week nightly ketogenic supplement to improve nighttime metabolism and muscle health

  We will test whether taking a ketogenic nutritional supplement each evening for 4 weeks helps older adults who are overweight improve their daily energy metabolism patterns and muscle health.

  Recruiting Maastricht University Medical Center · Maastricht · NCT07395973

• Neuromuscular balance exercises for people with overweight or obesity

  This project will test whether adding neuromuscular balance exercises to regular aerobic and strength training improves balance, functional capacity, and physical fitness in adults with overweight or obesity.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07372157

• Genotype-based versus standard dietary counseling to reduce weight and body fat.

  This test sees if dietary advice based on your genes helps Greek adults with overweight lose more weight and reduce body fat compared with standard dietary advice.

  Recruiting Metropolitan College · Marousi · NCT07368777

• Intermittent cottonseed oil intake to improve cholesterol and metabolic risk

  This trial will test whether taking cottonseed oil three times a week at two different doses can improve fasting and after-meal blood lipids and other risk markers in adults with high cholesterol or who are overweight.

  Recruiting University of Georgia · Athens, Georgia · NCT07246408

• LAE103 injections alone or with LAE102 for healthy overweight/obese adults and postmenopausal women

  This study will test whether injections of LAE103, alone or combined with LAE102, are safe and how the body processes them in healthy overweight or obese adults and in healthy postmenopausal women.

  Recruiting Phase 1 Laekna Limited · Sydney, New South Wales and 1 other locations · NCT07230496

• Daily postbiotic gummy plus nutrition advice for adults with overweight or obesity

  This project will test whether taking a daily postbiotic gummy together with nutritional advice helps adults with overweight or obesity improve body composition, glucose metabolism, and gut microbiota.

  Recruiting Clinica Universidad de Navarra, Universidad de Navarra · Pamplona, Navarre · NCT07165431

• Hands-on cooking classes to help young adults with intellectual disabilities keep weight off

  This program will test whether adding in-person cooking classes to a weight-loss plan helps young adults (18–35) with mild-to-moderate intellectual disabilities lose weight and keep it off.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT06961591

• Testing WVE-007 for adults with overweight or obesity

  This study is testing a new drug called WVE-007 to see if it is safe and well-tolerated in adults who are overweight or obese.

  Recruiting at 6 sites Phase 1/2 Wave Life Sciences USA, Inc. · Phoenix, Arizona and 6 other locations · NCT06842186

• Training to improve brain control and reduce excess weight

  This study is testing whether a new brain training method combined with a special type of brain stimulation can help people with excess weight make healthier choices and improve their overall well-being.

  Recruiting Universidad de Granada · Granada · NCT06668077

• Training to improve control over food cravings for people with excess weight

  This study is testing whether a special training program that helps people control their food cravings can help those with excess weight improve their eating habits and lose weight.

  Recruiting Universidad de Granada · Granada · NCT06600100

• Egg-derived peptide IRW tested for blood sugar, blood pressure, and weight.

  This project will test whether a small peptide from egg white (IRW), given in a smoothie, can quickly lower blood sugar and blood pressure in adults who have or are at high risk for type 2 diabetes.

  Recruiting Phase 1 University of Alberta · Edmonton, Alberta · NCT06555393

• Cooking demonstrations to improve health in Native Hawaiians

  This study is trying out cooking demonstrations to help Native Hawaiians manage heart and diabetes-related health issues by promoting traditional diets and healthier eating habits.

  Recruiting at 2 sites University of Hawaii · Honolulu, Hawaii and 1 other locations · NCT06526650

• Improving health in Native Hawaiians through traditional diets and cooking

  This study is testing if a program that promotes traditional Hawaiian diets and cooking can help Native Hawaiians with diet-related health issues improve their eating habits and overall health.

  Recruiting at 2 sites University of Hawaii · Honolulu, Hawaii and 1 other locations · NCT06526273

• Choosing AVOID or RESIST to help weight management

  Participants will test whether choosing a self-regulatory strategy (AVOID or RESIST) leads to better adherence to a weight-management program for overweight and obese adults.

  Recruiting Cedars-Sinai Medical Center · Beverly Hills, California · NCT06521021

• Early time-restricted eating to support postpartum weight loss

  This program will test whether an early time-restricted eating schedule helps postpartum women with overweight or obesity lose weight and is acceptable for them.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06491537

• Investigating the impact of a GLP-1 medication on brain insulin response

  This study is testing if a medication called semaglutide can change how the brain responds to insulin in people of different weights to see if it helps with thinking and eating habits.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06487832

• Diet-management app and smart scale for weight loss in people with heart failure and obesity

  This tests whether using a diet-management phone app at each meal plus a smart weight scale daily for 12 months helps people with heart failure and obesity live longer, avoid hospital stays, and feel less frail.

  Recruiting at 19 sites Heart Health Research Center · Beijing, Beijing Municipality and 25 other locations · NCT06455878

• Improving health in patients with COPD and sleep apnea through telehealth lifestyle changes

  This study is testing a telehealth program to see if it can help overweight and obese veterans with COPD and sleep apnea improve their health through lifestyle changes and support.

  Recruiting at 5 sites Seattle Institute for Biomedical and Clinical Research · Boise, Idaho and 4 other locations · NCT06390345

• Comparing the effects of cottonseed oil and matched PUFA on cholesterol levels

  This study is testing whether drinking meal replacement shakes with cottonseed oil can help lower cholesterol levels in adults at risk for heart disease compared to shakes with a different type of healthy fat.

  Recruiting University of Georgia · Athens, Georgia · NCT06382298

• Natural odor levels in spinal fluid after inhalation

  This study will test whether inhaling a natural odor leads to detectable levels of that odor in the spinal fluid and blood of lean and obese adults undergoing a lumbar puncture.

  Recruiting Early Phase 1 University Hospital, Basel, Switzerland · Basel and 1 other locations · NCT06370845

• Investigating insulin resistance using alpelisib in adults

  This study is testing if a drug called alpelisib can help us understand how insulin works in healthy adults compared to those at risk for type 2 diabetes.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06354088

• Effects of watermelon and low-fat cookies on health and wellness

  This study is testing whether eating fresh watermelon can improve health and wellness, especially for skin, gut, and sexual health, compared to eating low-fat cookies in healthy adults.

  Recruiting San Diego State University · San Diego, California · NCT06323070

• Maternal fecal transplant for babies born by cesarean section

  This trial will try giving a small fecal transplant from the mother to newborns delivered by elective C-section to see if it improves their gut microbiome and lowers the risk of later overweight or obesity.

  Recruiting Oulu University Hospital · Oulu · NCT06282952

• Nutrition care for patients with chronic pain

  This study is testing a new app that helps people with chronic pain improve their nutrition and overall health through a personalized program.

  Recruiting Linkoeping University · Linköping, Östergötland County · NCT06277232

• Using metformin to improve asthma control in overweight and obese adults

  This study is testing if the diabetes drug metformin can help overweight or obese adults with asthma feel better and manage their symptoms more effectively.

  Recruiting at 2 sites Phase 2 Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06273072

• Research on how obesity and bariatric surgery affect the body

  This study looks at how obesity affects the body and how bariatric surgery changes things for people who are obese, comparing them to healthy volunteers.

  Recruiting The Affiliated Hospital of Xuzhou Medical University · Xuzhou, Jiangsu · NCT06268262

• Using engineering principles to help maintain weight loss

  This study is testing a new way to help people keep off the weight they lost by using technology to track their habits and give them support when they're at risk of gaining it back.

  Recruiting Phase 2 The Miriam Hospital · Providence, Rhode Island · NCT06244888

• Increasing sleep duration to improve health in people with obesity

  This study is testing if getting an extra 2 hours of sleep each night can help people with obesity improve their health and insulin sensitivity.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06180837

• Combining dietary nitrate with calorie restriction to improve cognitive and vascular function in older adults

  This study is testing if drinking beetroot juice while following a calorie-restricted diet can help improve thinking and blood flow in healthy older adults who are overweight or obese.

  Recruiting University of Nottingham · Nottingham, Nottinghamshire · NCT06151015

• An acceptance-based healthy lifestyle program for overweight adolescent girls

  This study is testing a new healthy lifestyle program that helps overweight girls aged 14-19 learn to manage their weight and improve their health compared to a regular health education class.

  Recruiting Nemours Children's Clinic · Philadelphia, Pennsylvania · NCT06147973

• Understanding how caveolin-1 deficiency affects weight loss with GLP-1 receptor agonists

  This study is trying to see how a lack of caveolin-1 affects weight loss in overweight and obese adults using a specific weight loss medication called GLP-1 receptor agonists.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06069622

• Exploring the links between oral bacteria, muscle blood flow, and fitness levels

  This study is trying to see how oral bacteria and fitness levels affect blood flow to muscles in people.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06009276

• Rehabilitation with Nordic Walking for overweight and obese patients

  This study tests if Nordic Walking can help overweight and obese patients with diabetes and heart issues get fitter and feel better while also receiving standard rehabilitation support.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan · NCT05987410

• A program to help people lose weight through personalized diet and exercise

  This study is testing if a personalized diet and exercise program can help people who are overweight or obese lose weight more effectively than a standard diet plan.

  Recruiting Augusta University · Augusta, Georgia · NCT05956574

• Improving cardiometabolic health through circadian interventions

  This study is testing whether changing sleep habits and reducing nighttime light and eating can help people with overweight and obesity who don’t get enough sleep improve their health over eight weeks.

  Recruiting University of Utah · Salt Lake City, Utah · NCT05943626

• Using tirzepatide to improve metabolic health in people with obesity or overweight

  This study is testing if tirzepatide can help people with obesity or being overweight improve their metabolic health and lose weight over 22 weeks.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT05912621

• App plus smart body fat scale program to help overweight people with schizophrenia or bipolar disorder lose weight

  See if using the Huawei Health app together with a smart body fat scale helps overweight people with schizophrenia or bipolar disorder lose weight and stay involved in their care.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT05866107

• Managing weight gain during pregnancy with a new digital intervention

  This study is testing a new digital program to help pregnant women who are overweight or obese manage their weight gain during pregnancy.

  Recruiting Penn State University · University Park, Pennsylvania · NCT05807594

• Weight loss before pregnancy to reduce childhood obesity risk

  This study is testing if losing 10% of their weight before getting pregnant can help healthy couples with an overweight mother reduce the risk of their child becoming overweight later on.

  Recruiting University of Aarhus · Aarhus · NCT05798494

• Optimizing diet and physical activity for taxi drivers

  This study is trying to help taxi drivers who are overweight or obese make healthier choices about their diet and exercise through personalized support and tools.

  Recruiting Phase 2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT05770570

• Using mobile health apps to help manage weight in people with obesity

  This study is testing whether using a mobile health app can help people with obesity lose weight and improve their health over six months.

  Recruiting San Diego State University · San Diego, California · NCT05726942

• Understanding how obesity affects breathing and heart responses

  This study looks at how being overweight affects breathing and heart responses during exercise to help understand the connection between obesity and heart health.

  Recruiting Florida State University · Tallahassee, Florida · NCT05632406

• Health coaching for pregnant women to reduce postpartum weight retention

  This study is testing a health coaching program for Black and Latinx pregnant women to see if it helps them keep off extra weight after having a baby.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05619705

• Effects of dietary changes on food choices and brain function

  This study is testing if changing diets can help overweight and obese adults make better food choices and improve their brain function.

  Recruiting Max Planck Institute for Human Cognitive and Brain Sciences · Leipzig · NCT05353504

• Weight management combined with hormonal treatment for women with endometrial atypical hyperplasia

  This study is testing if combining weight management with hormonal treatments can help obese women with endometrial atypical hyperplasia who want to keep their fertility have better treatment results and pregnancy chances.

  Recruiting Phase 2/3 Fudan University · Shanghai · NCT05316493

• Food prescriptions to help Latino families eat healthier

  This study is testing a meal planning and grocery delivery service to see if it helps Latino families with overweight or obesity eat healthier and improve their health over six months.

  Recruiting Phase 3 Kaiser Permanente · Pasadena, California · NCT05309395

• Diabetes prevention program tailored for African Americans

  This study is testing a diabetes prevention program designed specifically for African Americans to see if a culturally tailored approach helps them lose weight and attend the program better.

  Recruiting Phase 2 University of Missouri, Kansas City · Kansas City, Missouri and 1 other locations · NCT05301413

• Comparing glycemic targets in overweight and obese women with gestational diabetes

  This study tests whether setting stricter blood sugar goals during pregnancy helps overweight and obese women with gestational diabetes have better outcomes for themselves and their babies.

  Recruiting at 5 sites Indiana University · Birmingham, Alabama and 4 other locations · NCT05124808

• Effects of different exercise modes during pregnancy on childhood obesity

  This study is testing how different types of exercise during pregnancy can affect the health of overweight and obese moms and their babies to see which workouts are best for preventing childhood obesity.

  Recruiting East Carolina University · Greenville, North Carolina · NCT04805502

• Investigating how exercise affects insulin resistance and heart function in diabetes

  This study is testing if regular exercise can help people with type 2 diabetes improve their heart function and reduce insulin resistance.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT04791371

• Registry of patients visiting the Obesity Clinic

  This study is creating a registry of people visiting the Obesity Clinic to gather information that can help improve treatment and care for obesity.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT04614961

• Examining how fat tissue expands during overeating

  This study is testing how fat tissue in the body changes when people overeat for a short time to see how it affects their overall health, especially regarding obesity and metabolic issues.

  Recruiting Pennington Biomedical Research Center · Baton Rouge, Louisiana · NCT04583514

• Weight loss method for people with overweight or obesity in primary care

  This study tests a new weight loss method called LEVA to see if it can help people with overweight or obesity in primary care lose weight and keep it off.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT04184479

• Study on how overweight and obesity affect puberty in children

  This study looks at how being overweight or obese affects the timing of puberty in children aged 6 to 12 by tracking their growth and environment over three years.

  Recruiting Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT04113070

• Effect of time-restricted feeding on weight loss

  This study is testing if eating within specific time limits can help people lose weight better than just cutting calories without time restrictions.

  Recruiting at 2 sites Federal University of Minas Gerais · Belo Horizonte, Minas Gerais and 1 other locations · NCT03574103

• Observational study on pregnancy and child health in Shenyang, China

  This study looks at how different factors affect the health of pregnant women and their children in Shenyang, China, by collecting information and samples from them over 18 years.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT03561766

• Comparing Liraglutide and Insulin Glargine for Type 2 Diabetes Management

  This study is testing if adding a medication called Liraglutide to insulin can help overweight and obese people with uncontrolled type 2 diabetes manage their blood sugar better and avoid weight gain compared to using a different type of insulin alone.

  Recruiting Phase 4 The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT03087032

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Game-based mobile app to help pregnant women with overweight/obesity manage weight in Nepal

  A new app designed for pregnant women in Nepal with overweight or obesity to help manage weight gain during pregnancy and reduce weight retention after birth.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11601016

• Nutrition and exercise plan to help overweight cancer survivors, using multi-omics to tailor care

  A cancer survivorship program combines a tailored diet and exercise plan with multi-omics data to personalize care for adults with overweight or obesity.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11457147

• Game-based mobile app to help pregnant women with overweight/obesity in Nepal manage weight

  A mobile app designed for pregnant women in Nepal who start pregnancy overweight or obese to help them manage weight gain and reduce postpartum weight retention.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11416297

• Creating a program to help adults maintain weight loss and prevent regain

  This study is all about helping adults who have lost weight keep it off for good by offering personalized support and strategies that adapt to their needs, making it easier for them to manage their weight in the long run.

  NIH research University of Utah · Salt Lake City, United States · NIH-11083649

• Using multi-omics to improve nutrition for cancer survivors with overweight and obesity

  This study is all about helping cancer survivors who are overweight or obese by creating a personalized nutrition and exercise program that uses their unique health information to improve their overall well-being.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11044159

• How the timing and nutrient status of aerobic exercise affects energy metabolism in adults with overweight and obesity

  This study is looking at how the time of day you exercise—morning or evening—and whether you've eaten before working out affects how your body burns energy, which could help people who are overweight or obese find better ways to lose weight and improve their health.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10886945

• Improving emotional skills to help teens manage their weight

  This study is all about helping teens aged 12 to 19 who are dealing with being overweight by teaching them how to manage their emotions better, which can lead to healthier eating and more active lifestyles.

  NIH research Miriam Hospital · Providence, United States · NIH-10884504

Related topics

Quick answers

How many Overweight and Obesity clinical trials are recruiting right now?

63, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (31 trials), China (10 trials), Spain (3 trials), Turkey (Türkiye) (2 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 3, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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