Understanding how fat tissue changes affect insulin sensitivity in older adults
Official title: Dissecting the cellular interplays of adipose tissue remodeling in the regulation of insulin sensitivity
Funded at University of California, San Francisco · NIH-10885130 · Data updated 2026-11-12
This study is looking at how changes in fat tissue can affect diabetes, especially in older adults, to help us understand why some people become resistant to insulin and how we can improve their health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $168,340 |
| NIH project number | 5K08DK124679-03 |
| Project ID | NIH-10885130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those who are overweight or obese and may be experiencing issues with insulin sensitivity.
✕Less likely to help
Patients who are not overweight or do not have issues related to insulin sensitivity may not benefit from this research.
What this research studies
This research investigates the relationship between obesity, fat tissue changes, and diabetes, particularly focusing on older adults. The study aims to understand how certain types of fat tissue can become dysfunctional and lead to insulin resistance, a precursor to diabetes. By analyzing a diverse group of individuals with varying levels of fat tissue health, researchers will explore the cellular and molecular mechanisms that influence insulin sensitivity. This approach combines experimental methods with advanced bioinformatics to uncover critical insights into fat tissue behavior.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving insulin sensitivity and preventing diabetes in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the role of fat tissue in metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Alba, Diana Lucia — University of California, San Francisco
- Study coordinator: Alba, Diana Lucia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.