How a specific enzyme in fat tissue affects insulin sensitivity
Official title: Adipose-Specific Phosphatidic Acid Acid Phosphatase Activity of Lipin 1 Regulates Systemic Insulin Sensitivity
Funded at University of Kansas Medical Center · NIH-10883666 · Data updated 2026-11-12
This study is looking at how a specific enzyme called Lipin 1 affects fat tissue and insulin sensitivity, especially in people with obesity, to help find better ways to understand and treat adult-onset diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 4, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $102,869 |
| NIH project number | 5K01DK126990-04 |
| Project ID | NIH-10883666 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing insulin resistance or obesity-related metabolic disorders.
✕Less likely to help
Patients who do not have issues with insulin sensitivity or obesity may not benefit from this research.
What this research studies
This research investigates the role of a specific enzyme, Lipin 1, in fat tissue and its impact on insulin sensitivity, particularly in the context of obesity. The study employs advanced metabolic and lipidomic analysis to identify new factors that contribute to insulin resistance when fat tissue is unable to store fat properly. By examining both animal models and cell cultures, the research aims to uncover mechanisms that could lead to better understanding and treatment of conditions like adult-onset diabetes. The principal investigator, Dr. Andrew Lutkewitte, is receiving mentorship from experts in the field to enhance his skills and knowledge in lipid metabolism and obesity.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving insulin sensitivity and managing obesity-related conditions.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism and its effects on insulin sensitivity, indicating that this approach has potential for success.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Lutkewitte, Andrew — University of Kansas Medical Center
- Study coordinator: Lutkewitte, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.