Weekly physiologic insulin sessions to improve insulin sensitivity and memory in Alzheimer’s

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with Alzheimer’s disease will receive a physiologic insulin intervention once a week for six months, with each session lasting up to two hours. Participants will have measures of insulin sensitivity, cognitive testing including the MoCA and the RMBPC, and brain glucose uptake measured by FDG-PET before and after the intervention. Adverse events and feasibility will be tracked throughout the study to determine safety and tolerability. The trial enrolls adults with MMSE scores below 25 and excludes those taking daily benzodiazepines, pregnant women, prisoners, and others judged unsuitable by the investigative team.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mini Mental State Examination (MMSE) score \< 25

Exclusion Criteria:

* On daily medication for the specific treatment of anxiety including benzodiazepines.
* An infant, child, or teenager
* A pregnant woman
* A prisoner
* Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).

Where it's running

• Pennington Biomedical Research Center
  Baton Rouge, Louisiana, United States Recruiting

Study contacts

• Principal investigator: Tim Gilbert, M.D. — Pennington Biomedical Research Center
• Study coordinator: Tim Gilbert, M.D.
• Email: Tim.Gilbert@pbrc.edu
• Phone: 2257632584

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.