Understanding how resistance exercise improves insulin sensitivity in diabetes
Official title: Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity
Funded at Mayo Clinic Rochester · NIH-11030575 · Data updated 2026-11-12
This study is looking at how strength training can help people with type 2 diabetes build muscle and improve how their bodies use insulin, so if you join, you'll get to work out while we learn more about how these exercises can benefit your health!
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 8, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $143,874 |
| NIH project number | 1K01DK141911-01 |
| Project ID | NIH-11030575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 2 diabetes who are looking to improve their insulin sensitivity and overall health through exercise.
✕Less likely to help
Patients who do not have type 2 diabetes or those who are unable to participate in physical exercise may not benefit from this research.
What this research studies
This research investigates how resistance exercise training (RET) can enhance muscle mass and improve insulin sensitivity in individuals with type 2 diabetes (T2D). The study aims to uncover the underlying mechanisms by which RET affects metabolism, particularly focusing on the role of post-translational modifications like acetylation and phosphorylation in muscle tissue. By analyzing changes in muscle proteins and their signaling pathways, the research seeks to provide insights that could lead to better exercise recommendations for managing T2D. Participants may engage in resistance training while researchers monitor their metabolic responses and muscle adaptations.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise strategies that enhance insulin sensitivity and overall metabolic health for patients with type 2 diabetes.
How similar studies have gone: Previous research has shown that resistance exercise can significantly improve insulin sensitivity in individuals with type 2 diabetes, indicating a promising avenue for further exploration.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Pataky, Mark William — Mayo Clinic Rochester
- Study coordinator: Pataky, Mark William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.