Condition
Healthy Aging clinical trials and research
As of November 12, 2026, Find a Trial lists 56 Healthy Aging clinical trials that are recruiting, at sites in 22 countries (most in United States (25), France (5), Canada (3)). By phase: Phase 1 (1), Phase 2 (1), Early Phase 1 (1). The most active sponsors are Massachusetts General Hospital (2), Amazentis SA (2), Rutgers, The State University of New Jersey (2). There are also 76 NIH-funded research projects on Healthy Aging, with $71.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 56Clinical trials
- 76NIH research projects
- 22Countries
Newest Healthy Aging clinical trials
All recruiting trials (56)
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Do Quercefit® or Ubiqsome™ help with aging and metabolic health in adults 50–75?
This study tests whether Quercefit® or Ubiqsome™ can improve aging markers, blood sugar, and heart health in sedentary adults aged 50–75 compared with a placebo.
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NVTIA Ergothioneine for Healthy Aging and Skin Health
This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.
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Miricell supplementation and markers of healthy aging
This trial tests whether taking Miricell once daily for 12 weeks improves cellular health and brain/metabolic indicators in adults aged 40–70 compared with a placebo.
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Does daily lean beef support brain health in older adults
In healthy adults aged 65 and up, this study tests whether eating lean beef every day for two weeks can influence brain health markers compared with a non-beef, protein-matched option.
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Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment
This study tests whether a computer-based training program can improve executive thinking in older adults, including those with mild cognitive impairment, and see if it also helps memory and well-being.
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SHARP: Personalized Health and Behavior Plan to Lower Biological Age in Older Adults
A 12-month randomized trial tests whether a personalized health and behavior program can lower biological age and improve function in healthy adults over 50.
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Hormones, Pain, and Exercise: Sports Bras for Full-Busted Women
This study tests whether specially designed sports bras can reduce neck, shoulder, arm, and back pain in full-busted women, and whether hormones, inflammation, or brain changes affect pain.
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Building a Russian biological age calculator and mapping aging patterns
This project will try to build a calculator that estimates biological age from health, lifestyle, and lab measures for adults in Russia.
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Wearable exoskeleton to support walking and balance in older adults and people with Parkinson's
This project will test whether a wearable robotic exoskeleton can help older adults and people with Parkinson's walk steadier, improve balance, and reduce effort.
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How regular meditation relates to thinking and emotion control
This study will see if people who regularly practice Isha-style meditation differ in cognitive skills and emotion regulation compared with people who do not meditate.
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Intensive tutoring versus flexible self-study to improve My Health Bank app use in adults over 50
This project will test whether one-on-one tutoring or flexible self-study with AI-created materials helps adults 50+ use the My Health Bank app more confidently and effectively.
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Daily collagen peptides for cellular aging in middle-aged adults
This trial will test whether taking daily collagen peptides for 24 weeks can stabilize or lengthen telomeres and improve cellular aging markers in adults aged 50–70 with overweight and low-to-moderate physical activity.
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iVS-1 probiotic to target biological aging in midlife adults
This trial will test whether taking a daily iVS-1 (Bifidobacterium adolescentis) probiotic for 150 days can change biological aging markers and improve metabolic, cognitive, sleep, and quality-of-life measures in adults aged 40–75.
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Digital tools to monitor aging health in rural Taiwan
This study tests a wearable and mobile health setup to help understand and support healthy aging in older adults living in Yunlin County, Taiwan.
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Urolithin A (Mitopure) to improve muscle strength in middle-aged adults
This study will test whether taking Mitopure (urolithin A) once daily for six months can improve muscle strength and performance in healthy 40–65-year-olds with low activity and lower aerobic fitness.
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Cognitive Vitality Pilot: 45-day supplement for thinking and mood
This study will test whether taking the liquid supplement Axolt daily for 45 days helps thinking and mood in healthy adults aged 55 and older.
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FAXAGE: Fasting and exercise to slow aging in older adults.
This project will test whether time-restricted eating, exercise, or both can slow biological aging in people 65 and older.
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Using ultra-high field and metabolic MRI to understand resilience and degeneration in the aging and diseased brain
This project will try advanced 3T and 7T MRI scans, including sodium and phosphorus imaging, to see if metabolic and connectivity changes explain resilience and degeneration in adults with MS, NMOSD, MOGAD, Alzheimer’s, Parkinson’s, or healthy aging.
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Plant-based diets for healthy aging
This project will test whether vegetarian and plant-based diets help middle-aged and older Tzu Chi volunteers maintain physical function and cognitive health as they age.
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Humiome® Post LB for stress, anxiety, sleep, and thinking in older adults
This will test whether taking Humiome® Post LB every day for 90 days helps reduce stress and anxiety and improve sleep and memory in healthy adults aged 50–75.
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Freeze-dried grape powder to support immune health in adults 50-75.
This will see if drinking a daily freeze-dried grape powder beverage changes immune, inflammation, and metabolism markers in healthy adults ages 50 to 75.
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Neuroathletic exercise to improve walking, balance, and thinking in older adults
This program will test whether neuroathletic exercises can boost walking speed, lower fall risk, and help cognitive function in healthy adults aged 60–80.
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Multitasking strategy training to boost executive control in healthy older adults
This trial tests whether a web-based multitasking game, with or without strategy training, helps healthy adults aged 60–75 improve their executive control.
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Using brain stimulation to improve memory and motivation in older adults
This study is testing if a type of brain stimulation can help improve memory and motivation in older adults, including those showing early signs of Alzheimer's disease.
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Evaluating the effects of injectable Niagen®+ compared to NAD+ for healthy aging
This study is testing if an injectable form of vitamin B3 called Niagen®+ is safe and effective for healthy aging compared to another treatment called NAD+ in healthy adults.
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Integrated care program for frail older adults in Barcelona
This study is testing a new exercise program in Barcelona to see if it helps frail older adults get stronger and stay independent longer.
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Investigating swallowing issues in adults with and without Alzheimer's disease
This study is testing how swallowing problems differ between adults with Alzheimer's disease and healthy older adults to see how it affects both the patients and their caregivers.
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Assessing balance control in older adults with diabetic peripheral neuropathy
This study tests how diabetic peripheral neuropathy affects balance and muscle activity in adults over 50 to see if it increases their risk of falling.
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Investigating how different focus strategies during strength training affect gait in older adults
This study is testing how different ways of focusing during strength training can improve walking and movement in healthy older adults.
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Evaluating the effects of exercise, mindfulness, and nutrition on healthy aging
This study is testing if a mix of exercise, mindfulness, and healthy eating can improve key health markers in people aged 50 to 75 who don't have neurological disorders.
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Virtual registry for menopause and perimenopause in Australia
This study is creating an online registry to collect information from Australian women about their experiences with menopause and perimenopause to help improve healthcare and support for them.
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Nicotinamide Riboside and Exercise for Healthy Aging
This study is testing if taking a supplement called nicotinamide riboside along with exercise can help older adults feel healthier and age better.
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Understanding how brain processes affect sentence production in people with aphasia
This study is trying to understand how the brain works when people with post-stroke aphasia struggle to form sentences, in hopes of finding better ways to help them communicate.
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Using spatial navigation to detect early Alzheimer's disease.
This study is testing if using spatial navigation tasks can help spot early signs of Alzheimer's disease in people with mild cognitive impairment and mild dementia.
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Understanding how aging affects time perception and brain function
This study is trying to see how aging affects the way we perceive time and how our brains work, by comparing younger and older adults during various tasks.
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Assessing gait and balance in rare neurological diseases
This study looks at how walking and balance are affected in people with rare neurological diseases to better understand their challenges and risks of falling.
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Determining the dietary tryptophan needs of older adults
This study is testing how much tryptophan older adults need in their diet to stay healthy and support their body's protein needs.
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Motor imagery training to improve balance in older adults
This study tests if combining motor imagery training with watching actions can help older adults improve their balance better than just using virtual reality balance training alone.
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Training program to improve end-of-life care for older African Americans
This study is testing a training program for healthcare providers to improve end-of-life care for older African Americans by focusing on their cultural values and experiences.
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Testing the sense of smell to assess brain health in older adults
This study is testing if a smell test can help identify brain health issues in older adults who have memory concerns or mild cognitive problems.
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Improving language comprehension in Lewy body disease using brain stimulation
This study is testing if a type of brain stimulation can help improve language skills in older adults with Lewy body disease and mild cognitive impairment.
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Perceptual training to improve balance and motion sensing in older adults
This test tries whether repeated motion-feedback training can help older adults (65–89) better detect whole-body tilts and translations and improve their balance.
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Arm-in-arm walking program for older adults at risk of falling
This study tests if a special walking program with a younger partner can help older adults at risk of falling improve their balance and overall well-being.
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Exercise to enhance brain health in older African Americans
This study is testing whether two types of exercise, Cardio-Dance Fitness and Strength, Flexibility, and Balance, can help improve brain health and lower Alzheimer's risk in older African Americans.
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Testing beet-root juice and red light therapy for muscle endurance in older adults
This study is testing whether beet-root juice and red light therapy can help older adults improve their muscle endurance.
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Examining how autophagy affects blood vessel function in Type 2 Diabetes
This study is testing if a supplement that boosts a process called autophagy can improve blood vessel function in adults with Type 2 Diabetes.
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Effects of electrical stimulation on fatigue in healthy individuals
This study tests if a mild electrical current applied to the neck can help healthy adults feel less tired and improve their muscle performance.
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Longitudinal study of Victorian children and their parents
This study is looking at the health and wellbeing of children born in Victoria and their parents over time to see how different factors affect their physical and mental health.
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Wellness program for promoting healthy aging
This study is testing a wellness program that includes exercise, diet, and mental health support to see if it helps older adults stay healthy and active as they age.
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Investigating risk factors for disability progression in Multiple Sclerosis
This study is trying to find out what factors might make disability get worse in people with Multiple Sclerosis by looking at their medical history and MRI scans.
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Short mild low-oxygen sessions to support brain blood-vessel health in older adults
We will test whether brief, controlled sessions of mild low-oxygen exposure, alone or combined with rehabilitative exercise, can improve brain blood-vessel function in inactive people aged 60 to 80.
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Assessing Urolithin A Levels in Home-Collected Blood Samples
This study is testing how well people can collect their own blood samples at home to see if a supplement or pomegranate juice can help measure levels of Urolithin A, which might be important for healthy aging.
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Examining iron levels in the brain during healthy aging
This study looks at how iron levels in the brain change as people age and whether this affects their thinking skills, involving healthy adults from 18 to 95 years old.
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Training to improve balance and prevent falls
This study is testing different training devices to see if they can help healthy young adults, healthy older adults, and stroke survivors improve their balance and reduce the risk of falls.
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Effects of melatonin on brain health and cognition in older adults
This study is testing if taking 5mg of melatonin can improve brain health and thinking skills in older adults, especially those with mild cognitive impairment, over nine months.
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Longitudinal study on brain health and risk factors for neurological diseases
This study is trying to understand how different health factors affect brain health over time in people who are at risk for conditions like stroke and dementia.
NIH-funded research (newest 40 of 76)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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MyGoals for Healthy Aging among people at risk for Alzheimer’s dementia
A multi-center trial tests whether a combined program addressing poverty-related stress and executive function can slow aging and reduce risk factors for Alzheimer’s disease in adults.
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Healthy aging in Black adults and its links to dementia risk
This grant follows a large group of Black adults to understand how aging, brain health, and life experiences influence Alzheimer’s disease and related dementias.
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How early-life spending shape aging and dementia risk later in life
A Stanford-led study looks at how state and county spending in childhood may influence midlife thinking skills and the risk of dementia in later life.
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Costa Rica long-lived older adults follow-up (Wave 4)
We will re-contact Costa Rican adults aged 70 and older (and their spouses) to collect health, thinking, and blood information to find what helps people live longer and stay mentally sharp.
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Mapping tiny blood vessels in the brain's memory area and how they relate to Alzheimer's changes
Researchers are using ultra-high-resolution brain scans and tissue staining to map tiny blood vessels in the entorhinal cortex to learn how those patterns relate to Alzheimer's disease.
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The chemical language of human gut bacteria and aging
A Duke University study will look at how healthy aging is linked to molecules produced by gut bacteria, with a focus on people who might be at risk for Alzheimer’s disease.
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Sensory guidance of how diet affects healthy aging
Researchers will study how the way we experience food and our senses influence aging, using fruit-fly models to mirror human dietary choices.
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Systems biology study of aging in pet dogs
Aging, the biggest risk for many diseases, will be studied in pet dogs by looking at how genes, the microbiome, metabolism, and epigenetics together influence healthy aging.
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The Dog Aging Project: How genes and environment shape healthy aging in pet dogs
A large, long-term study using pet dogs to understand why some dogs stay healthier longer and what factors in their genes and environment influence aging.
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PROSPERing: Tailored Exercise in HIV Care to Ease Symptoms and Support Healthy Aging
A clinic-based, personalized exercise program for adults living with HIV is being tested to help reduce symptom burden and promote healthier aging.
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Aiming to keep older adults healthier by adjusting certain dietary amino acids
A study at a major university tests whether reducing specific dietary amino acids can improve obesity and blood sugar control in aging, with the goal of healthier aging for adults 65 and older.
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Circadian clocks and muscle fats: how timing keeps mitochondria healthy as we age
A study in adults will test how circadian timing in muscles affects mitochondrial function to support healthy aging.
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Targeting how the cell’s recycling factories change shape to support healthy aging
A study at Tufts University Boston is exploring how organelles called peroxisomes change their shape and function during fasting to support lipid metabolism and healthy aging.
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Long-term study of aging in Egypt to learn about dementia in diverse populations
A nationwide study in Egypt will track aging and dementia over time to help understand risk and resilience factors that may also affect people in the United States.
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MyGoals for Healthy Aging: A Multi-Center Trial to Help Older Adults
A multi-center study tests ways to slow aging and help people with Alzheimer’s-related dementia by reducing poverty-related stress and improving daily functioning.
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MyGoals Healthy Aging program
This program offers extended employment supports and coaching to help low-income older adults slow aging and lower their risk of Alzheimer’s and related dementias.
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Memory and vision in aging and mild cognitive impairment
This project uses brain imaging to understand how aging and amnestic mild cognitive impairment change how visual memories are stored and used.
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How cell-specific DNA elements may drive Alzheimer's disease and aging
Researchers are studying how certain DNA elements that can move around the genome contribute to Alzheimer’s disease and aging, using samples from adults and people with related risk factors.
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Chemical ways to support brain protein health to promote aging well
Aims to help the aging brain keep proteins properly folded by carefully adjusting protein production, with potential relevance to Alzheimer’s disease in the future.
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MyGoals for Healthy Aging
This project tests whether giving low-income adults employment incentives plus coaching to improve thinking skills can slow age-related health problems linked to Alzheimer's disease.
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Healthy Aging and Dementia Biomarkers in older adults
A long-term study follows aging adults to find early brain changes that predict Alzheimer's disease so future patients can benefit from earlier detection and care.
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Somatic mutations and aging in healthy people
Huge questions about aging may be unlocked by looking at tiny DNA changes in blood from healthy people over time.
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Automated MRI Scan to Learn About Muscle, Bone, and Fat for Healthy Aging
A new MRI-based tool uses artificial intelligence to automatically measure muscles, bones, and fat to help aging individuals stay strong and independent.
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How certain DNA elements affect aging and Alzheimer's disease
This study is looking at how certain genetic elements in our DNA might affect healthy aging and Alzheimer's disease by examining brain cells and signals in mice, which could help us understand more about these conditions.
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Finding molecules that help the hippocampus make and keep neurons in aging and Alzheimer's
Researchers are using new lab methods to find proteins and genes that help hippocampus cells make and maintain new neurons in older adults and people with Alzheimer's disease.
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Costa Rica Longevity and Healthy Aging — Wave 4 (CRELES)
This project continues interviews, physical checks, blood tests, and new memory testing for older adults in Costa Rica to understand aging and dementia.
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Physical resilience predicts healthier aging
This research looks at whether the body's ability to recover from physical stress predicts healthier aging in middle-aged and older people.
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Lactate's role in boosting brain energy during aging
A short, easy-to-understand study is exploring whether lactate can help aging brains use glucose more efficiently to support memory and thinking.
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Perilipin 5: how a fat-droplet protein helps cells sense nutrients to support healthy aging
It explores how a protein on fat droplets helps cells use fats to trigger protective signals that could keep people healthier as they age.
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AI-powered metabolic clock for aging and Alzheimer's disease
Researchers will study metabolic signals in blood or other biofluids to understand how aging and Alzheimer’s disease begin and progress, using advanced AI to find patterns that might predict dementia risk.
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How diet and metabolism affect healthy aging
This study is looking at how changing what we eat, especially by cutting back on certain nutrients like protein, can help older adults stay healthier as they age, and it’s exploring how a hormone called FGF21 and a specific cellular process work together to support this.
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Healthy Aging in Egypt (AL-SEHA)
This project follows older adults across Egypt over time to track health, thinking skills, and social and environmental factors that influence aging.
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Muscle body clock and mitochondrial health to support better aging
This work explores whether boosting the muscle 'body clock' can help keep muscles and their energy makers (mitochondria) healthier as people age.
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Measuring stress and building supports to help people age more healthily
This project develops better ways to track psychological stress and creates scalable programs to help older adults, especially those from underserved groups, stay healthier as they age.
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Lowering specific dietary amino acids to support healthy aging
Researchers are testing whether reducing three amino acids in the diet can help older adults with obesity or type 2 diabetes lose fat and improve blood sugar control.
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Healthy aging and medication management for World Trade Center responders
This project helps World Trade Center responders age well and manage their medications safely as they get older.
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How inner ear changes affect balance and fall risk as we age
This project looks at whether age-related changes in the inner ear make balance worse and raise the chance of falling for older adults.
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Understanding Genetic Elements in Brain Cells and Their Role in Alzheimer's Disease and Healthy Aging
This project explores how specific genetic elements in brain cells might cause Alzheimer's disease and affect how our brains age.
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Healthy aging for adults on the autism spectrum
This project follows autistic and non-autistic adults over time to learn how physical health, mental health, thinking skills, and the brain change with age.
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Understanding Healthy Aging in African Americans
This project looks at how memory and thinking skills change over time in middle-aged and older African Americans, especially focusing on factors that might protect against or lead to Alzheimer's disease.
Related topics
Quick answers
How many Healthy Aging clinical trials are recruiting right now?
56, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 22 countries. The most sites are in United States (25 trials), France (5 trials), Canada (3 trials), Australia (2 trials), Taiwan (2 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 1, Phase 2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.