How certain DNA elements affect aging and Alzheimer's disease
The Role of Transposable Elements in Healthy Aging and in Alzheimer's Disease
['FUNDING_OTHER'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-11321491
This study is looking at how certain genetic elements in our DNA might affect healthy aging and Alzheimer's disease by examining brain cells and signals in mice, which could help us understand more about these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-11321491 on ClinicalTrials.gov |
What this research studies
This research investigates the role of transposable elements, particularly human endogenous retroviruses, in the processes of healthy aging and Alzheimer's disease. By analyzing RNA sequencing data, the study aims to identify patterns of gene expression related to these elements in different brain regions and cell types. The researchers are also exploring the impact of specific signaling pathways on neurodegeneration using a mouse model. This approach could provide insights into the molecular mechanisms underlying aging and Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals at risk for Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those with other unrelated neurological conditions may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating Alzheimer's disease and improving healthy aging.
How similar studies have performed: While the role of transposable elements in disease is an emerging field, preliminary studies have shown promising results in understanding their impact on neurodegeneration.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIXON, DOUGLAS F — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: NIXON, DOUGLAS F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.