Building a Russian biological age calculator and mapping aging patterns

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-center cross-sectional study will enroll at least 3,500 adults across Russia, grouped in 5-year age bands, and involves a single clinic visit. Investigators will collect socioeconomic data, lifestyle information, physical measurements, cognitive tests, and laboratory biomarkers, and will create a biobank of blood, serum, plasma, and urine. Using these multidimensional data, researchers will develop and validate mathematical models to estimate biological age tailored to the Russian population. The study will also describe aging phenotypes across age groups and explore links between socioeconomic/lifestyle factors and the rate of biological aging.

Why it matters

Who can join: the full rules

Inclusion Criteria: Signing the informed consent form to participate in the study.

Participant's age was 18 years or older at the time of inclusion in the study.

\-

Exclusion Criteria:

1. Refusal to participate in the study or to provide informed consent.
2. History or medical records indicating the presence of infectious diseases (Hepatitis C, Hepatitis B, including HBsAg carrier status, HIV infection).
3. Presence of an acute illness/condition, exacerbation of a chronic disease, or surgical intervention within the last month prior to study inclusion.
4. Lack of remission from an oncological disease or ongoing anti-tumor therapy initiated less than three years prior to study inclusion.
5. Severe cognitive or sensory impairments and mental disorders that, in the investigator's opinion, preclude adequate communication with the subject.
6. Severe forms of chronic non-communicable diseases: life-threatening cardiac arrhythmias, chronic heart failure NYHA Class III-IV, left ventricular ejection fraction \<40%, ischemic heart disease CCS Class III-IV, chronic kidney disease Stages 4-5, type 1 diabetes mellitus, type 2 diabetes mellitus with terminal stages of complications, systemic connective tissue diseases, chronic obstructive pulmonary disease with respiratory failure of Grade 1 or higher, bronchial asthma requiring glucocorticosteroid therapy, osteoarthritis Kellgren-Lawrence Grade IV, body mass index (BMI) ≥40 kg/m², as well as documented history of myocardial infarction (MI) or acute cerebrovascular accident (stroke).
7. Pregnancy or lactation (breastfeeding).
8. Any other factors that, in the investigator's opinion, may preclude the participant's inclusion in the study.

   Additional exclusion criteria for participants undergoing stool sample collection:
9. Use of systemic antibiotics for 3 or more days within the 3 months prior to the study start.
10. Any invasive procedures on the large intestine within the last 3 weeks prior to the study start.

Where it's running

• Pirogov Russian National Research Medical University
  Moscow, Russia Recruiting

Study contacts

• Study coordinator: Liubov Machekhina, MD, PhD
• Email: machehina_lv@rgnkc.ru
• Phone: +79037488543

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Do Quercefit® or Ubiqsome™ help with aging and metabolic health in adults 50–75?

  This study tests whether Quercefit® or Ubiqsome™ can improve aging markers, blood sugar, and heart health in sedentary adults aged 50–75 compared with a placebo.

  Recruiting Applied Science & Performance Institute · Tampa, Florida · NCT07760506

• NVTIA Ergothioneine for Healthy Aging and Skin Health

  This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.

  Recruiting European Life Science Research Association · Dhaka · NCT07750002

• Miricell supplementation and markers of healthy aging

  This trial tests whether taking Miricell once daily for 12 weeks improves cellular health and brain/metabolic indicators in adults aged 40–70 compared with a placebo.

  Recruiting Nutraland USA, Inc. · Canfield, Ohio · NCT07675200

• Does daily lean beef support brain health in older adults

  In healthy adults aged 65 and up, this study tests whether eating lean beef every day for two weeks can influence brain health markers compared with a non-beef, protein-matched option.

  Recruiting South Dakota State University · Brookings, South Dakota · NCT07623785

• Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment

  This study tests whether a computer-based training program can improve executive thinking in older adults, including those with mild cognitive impairment, and see if it also helps memory and well-being.

  Recruiting at 2 sites Universidad Antonio de Nebrija · Madrid, Madrid and 1 other locations · NCT07598409

• SHARP: Personalized Health and Behavior Plan to Lower Biological Age in Older Adults

  A 12-month randomized trial tests whether a personalized health and behavior program can lower biological age and improve function in healthy adults over 50.

  Recruiting Sheba Medical Center · Ramat Gan, Tel Aviv · NCT07596576

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.