Building a Russian biological age calculator and mapping aging patterns
RUSS-AGE, CREATING OF A BIOLOGICAL AGE CALCULATOR AND STUDY OF AGING PHENOTYPES IN THE RUSSIAN POPULATION
This project will try to build a calculator that estimates biological age from health, lifestyle, and lab measures for adults in Russia.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Pirogov Russian National Research Medical University Academic / other |
| Locations | 1 site (Moscow) |
| Trial ID | NCT07574359 on ClinicalTrials.gov |
What this trial studies
This multi-center cross-sectional study will enroll at least 3,500 adults across Russia, grouped in 5-year age bands, and involves a single clinic visit. Investigators will collect socioeconomic data, lifestyle information, physical measurements, cognitive tests, and laboratory biomarkers, and will create a biobank of blood, serum, plasma, and urine. Using these multidimensional data, researchers will develop and validate mathematical models to estimate biological age tailored to the Russian population. The study will also describe aging phenotypes across age groups and explore links between socioeconomic/lifestyle factors and the rate of biological aging.
Who should consider this trial
Good fit: Adults aged 18 years or older in Russia who can provide informed consent and attend a single clinic visit are the intended participants.
Not a fit: People with recent acute illness or surgery, active infections (HIV, hepatitis B or C), recent cancer treatment, or severe uncontrolled chronic diseases are excluded and may not benefit from participation.
Why it matters
Potential benefit: If successful, the calculator could give people and clinicians a more accurate measure of physiological aging to help personalize prevention and guide future geroprotective research.
How similar studies have performed: Other teams have produced epigenetic and phenotypic aging clocks that show promising links to health outcomes, but those models were mostly derived from non-Russian populations and may not generalize locally.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Signing the informed consent form to participate in the study. Participant's age was 18 years or older at the time of inclusion in the study. \- Exclusion Criteria: 1. Refusal to participate in the study or to provide informed consent. 2. History or medical records indicating the presence of infectious diseases (Hepatitis C, Hepatitis B, including HBsAg carrier status, HIV infection). 3. Presence of an acute illness/condition, exacerbation of a chronic disease, or surgical intervention within the last month prior to study inclusion. 4. Lack of remission from an oncological disease or ongoing anti-tumor therapy initiated less than three years prior to study inclusion. 5. Severe cognitive or sensory impairments and mental disorders that, in the investigator's opinion, preclude adequate communication with the subject. 6. Severe forms of chronic non-communicable diseases: life-threatening cardiac arrhythmias, chronic heart failure NYHA Class III-IV, left ventricular ejection fraction \<40%, ischemic heart disease CCS Class III-IV, chronic kidney disease Stages 4-5, type 1 diabetes mellitus, type 2 diabetes mellitus with terminal stages of complications, systemic connective tissue diseases, chronic obstructive pulmonary disease with respiratory failure of Grade 1 or higher, bronchial asthma requiring glucocorticosteroid therapy, osteoarthritis Kellgren-Lawrence Grade IV, body mass index (BMI) ≥40 kg/m², as well as documented history of myocardial infarction (MI) or acute cerebrovascular accident (stroke). 7. Pregnancy or lactation (breastfeeding). 8. Any other factors that, in the investigator's opinion, may preclude the participant's inclusion in the study. Additional exclusion criteria for participants undergoing stool sample collection: 9. Use of systemic antibiotics for 3 or more days within the 3 months prior to the study start. 10. Any invasive procedures on the large intestine within the last 3 weeks prior to the study start.
Where this trial is running
Moscow
- Pirogov Russian National Research Medical University — Moscow, Russia (Recruiting)
Study contacts
- Study coordinator: Liubov Machekhina, MD, PhD
- Email: machehina_lv@rgnkc.ru
- Phone: +79037488543
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.