Evaluating the effects of exercise, mindfulness, and nutrition on healthy aging
Impact 360 Study for Healthy Agers
NA · University of British Columbia · NCT06516146
This study is testing if a mix of exercise, mindfulness, and healthy eating can improve key health markers in people aged 50 to 75 who don't have neurological disorders.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | University of British Columbia (other) |
| Locations | 1 site (Vancouver, British Columbia) |
| Trial ID | NCT06516146 on ClinicalTrials.gov |
What this trial studies
The Impact 360 study investigates how a combined intervention of exercise, mindfulness, and nutrition affects eight key health indicators in individuals aged 50 to 75 without neurological disorders. This interventional study employs a partial crossover design, where participants will either receive the intervention immediately or after a waitlist period. The study aims to understand the mechanisms behind the benefits of this multimodal approach and its impact on overall health, including cognition, inflammation, microbiome diversity, and more. The findings will also serve as a normative dataset for future studies in clinical populations.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 50 to 75 who can engage in exercise and have access to a smartphone for monitoring.
Not a fit: Patients with neurological disorders or significant cognitive impairments will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance overall health and well-being in older adults, potentially delaying the onset of neurological diseases.
How similar studies have performed: While individual interventions have shown benefits, this multimodal approach is relatively novel and has not been extensively tested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are able to complete questionnaires and follow directions for interventions * Have access to a smartphone that can support the Fitbit app Exclusion Criteria: * Any neurological disease/disorder diagnosis (Ex: Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury, Brain lesion, Stroke, etc) * Any chronic medical condition which would affect ability to participate in exercise * Any contraindication for exercise based on the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and medical clearance form * Participants who were told by a medical doctor that they need to be medically supervised for exercise * Montreal Cognitive Assessment (MoCA) scores \<21/30 * Significant cognitive impairment, depression, or eating disorder * Any contraindication to MRI scanning; such as implanted metal clips or wires (see list below) * Participants currently doing 180 minutes or more of moderate-vigorous intensity exercise per week AND either of the following: * Completion of an Mindfulness-Based Stress Reduction course OR; Score \>8/15 in the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) Diet Questionnaire * Significant or unstable cardiovascular or respiratory disease * Severe/multiple head trauma(s) * Subjects who are pregnant or breastfeeding * Subjects with a history or major episodes of drug or alcohol abuse * Chronic/acute bacterial/viral infection * GI cancer * Inflammatory bowel disease Exclusion for MRI scanning: * Individuals weighing \> 400 lbs (limit of MRI machine) * Artificial heart valve * Brain aneurysm clip * Electrical stimulator for nerves or bones * Ear or eye implant * Implanted drug infusion pump * Coil, catheter, or filter in any blood vessel * Orthopedic hardware (artificial joint, plate, screws) * Other metallic prostheses * Shrapnel, bullets, or other metal fragments * Surgery or tattoos (including tattooed eyeliner) in the last six weeks * Brain surgery * Have a cardiac pacemaker, wires or defibrillator * Have had an injury where a piece of metal lodged in the eye or orbit * Have a ferromagnetic aneurysm clip
Where this trial is running
Vancouver, British Columbia
- University of British Colombia — Vancouver, British Columbia, Canada (RECRUITING)
Study contacts
- Principal investigator: Silke Appel-Cresswell, MD, FRCPC — University of British Colombia
- Study coordinator: Jeffrey Kelly, MSc
- Email: jeffrey.kelly@ubc.ca
- Phone: 6048274230
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Aging, Exercise, Mindfulness, Microbiome, Well-Being