Evaluating the effects of exercise, mindfulness, and nutrition on healthy aging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Impact 360 study investigates how a combined intervention of exercise, mindfulness, and nutrition affects eight key health indicators in individuals aged 50 to 75 without neurological disorders. This interventional study employs a partial crossover design, where participants will either receive the intervention immediately or after a waitlist period. The study aims to understand the mechanisms behind the benefits of this multimodal approach and its impact on overall health, including cognition, inflammation, microbiome diversity, and more. The findings will also serve as a normative dataset for future studies in clinical populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants who are able to complete questionnaires and follow directions for interventions
* Have access to a smartphone that can support the Fitbit app

Exclusion Criteria:

* Any neurological disease/disorder diagnosis (Ex: Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury, Brain lesion, Stroke, etc)
* Any chronic medical condition which would affect ability to participate in exercise
* Any contraindication for exercise based on the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) and medical clearance form
* Participants who were told by a medical doctor that they need to be medically supervised for exercise
* Montreal Cognitive Assessment (MoCA) scores \<21/30
* Significant cognitive impairment, depression, or eating disorder
* Any contraindication to MRI scanning; such as implanted metal clips or wires (see list below)
* Participants currently doing 180 minutes or more of moderate-vigorous intensity exercise per week AND either of the following:
* Completion of an Mindfulness-Based Stress Reduction course OR; Score \>8/15 in the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) Diet Questionnaire
* Significant or unstable cardiovascular or respiratory disease
* Severe/multiple head trauma(s)
* Subjects who are pregnant or breastfeeding
* Subjects with a history or major episodes of drug or alcohol abuse
* Chronic/acute bacterial/viral infection
* GI cancer
* Inflammatory bowel disease

Exclusion for MRI scanning:

* Individuals weighing \> 400 lbs (limit of MRI machine)
* Artificial heart valve
* Brain aneurysm clip
* Electrical stimulator for nerves or bones
* Ear or eye implant
* Implanted drug infusion pump
* Coil, catheter, or filter in any blood vessel
* Orthopedic hardware (artificial joint, plate, screws)
* Other metallic prostheses
* Shrapnel, bullets, or other metal fragments
* Surgery or tattoos (including tattooed eyeliner) in the last six weeks
* Brain surgery
* Have a cardiac pacemaker, wires or defibrillator
* Have had an injury where a piece of metal lodged in the eye or orbit
* Have a ferromagnetic aneurysm clip

Where it's running

• University of British Colombia
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Silke Appel-Cresswell, MD, FRCPC — University of British Colombia
• Study coordinator: Jeffrey Kelly, MSc
• Email: jeffrey.kelly@ubc.ca
• Phone: 6048274230

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.