Investigating risk factors for disability progression in Multiple Sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify risk factors that contribute to disability progression in Multiple Sclerosis and related disorders. Participants will undergo a comprehensive screening process at Cedars-Sinai Medical Center, where their medical and MRI records will be reviewed to determine eligibility. The main research will involve collecting demographic data, medical history, and conducting quantitative disability assessments, alongside optional sub-studies that may include blood draws and additional MRI scans. The study will utilize historical and ongoing MRI data to predict changes in disability measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects who meet any one of the following diagnostic criteria:

  * Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
  * Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
  * Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
  * Diagnosis of neurological disorders other than MSRD.
  * Healthy volunteer.
* Age ≥18.
* Able to give informed consent.

Exclusion Criteria:

* Patients will be excluded from the MRI portions of the study if they have a contraindication to MRI(metallic implantsor foreign bodies, claustrophobia, MRI-incompatible pacemakers, MRI- incompatible prosthetic heart valves).
* Patients will be excluded from the MRI portions of the study if they are pregnant, but their demographic, clinical information,and disability measures may still be captured under the study.
* Patients will be excluded from the visual assessment portions of the study if they have had any recent ocular surgery (within the past two months), refractive errors of greater than or equal to ±6 diopters or other eye diseases that may affect or confound OCT/OCTA measurements (ex., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma).

Where it's running

• Cedars-Sinai Medical Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Omar Al-Louzi, MD — Cedars-Sinai Medical Center
• Study coordinator: Omar Al-Louzi, MD
• Email: omar.allouzi@cshs.org
• Phone: (310) 423-4008

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.