Examining iron levels in the brain during healthy aging
Study of Iron Accumulation Measured in MRI in Non-pathological Aging
This study looks at how iron levels in the brain change as people age and whether this affects their thinking skills, involving healthy adults from 18 to 95 years old.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 190 (estimated) |
| Ages | 18 Years to 95 Years |
| Sex | All |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Trial ID | NCT04659824 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between iron accumulation in the brain, as measured by MRI, and the age of healthy individuals. It will also explore how this iron load correlates with cognitive performance, various aging markers, and demographic factors. Participants will undergo MRI scans to assess their brain iron levels, and their cognitive abilities will be evaluated to understand potential impacts of iron accumulation on aging. The study focuses on a wide age range, from 18 to 95 years old, to capture a comprehensive view of healthy aging.
Who should consider this trial
Good fit: Ideal candidates are healthy men and women aged 18 to 95 who are French speakers and can provide informed consent.
Not a fit: Patients with neurological or psychiatric disorders, or those who have contraindications for MRI, are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of brain health in aging and inform strategies to maintain cognitive function.
How similar studies have performed: While studies on brain iron accumulation exist, this specific approach focusing on healthy aging is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men or women between 18 and 95 years old * French speaker with capability to understand the instructions * Health insurance Exclusion Criteria: * Pregnancy * minor subject * no informed consent agreement * subject enrolled in pharmaceutic study or exclusion period * MRI contra-indications * Neurological or psychiatric disorders * MOCA \< 26 * Psychotropic drugs * More than 3 MRI exams * More than 1 neuropsychological assessment (same cognitive tests) in the last 12 months * Unable to follow the entire protocol according to the investigator
Where this trial is running
Lille
- Hopital Roger Salengro, CHU Lille — Lille, France (Recruiting)
Study contacts
- Principal investigator: Grégory KUCHCINSKI, MD — University Hospital, Lille
- Study coordinator: Grégory KUCHCINSKI, MD
- Email: gregory.kuchcinski@chru-lille.fr
- Phone: 0320445962
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.