Clinical trial Recruiting at 1 site Observational Ages 18 to 95

Examining iron levels in the brain during healthy aging

Official title: Study of Iron Accumulation Measured in MRI in Non-pathological Aging

Run by University Hospital, Lille · NCT04659824 · Data updated 2026-11-12

This study looks at how iron levels in the brain change as people age and whether this affects their thinking skills, involving healthy adults from 18 to 95 years old.

Quick facts

Study typeObservational
Ages18 Years to 95 Years
SexAll
Enrollment190 (estimated)
SponsorUniversity Hospital, Lille
Academic / other
Locations1 site (Lille)
StatusRecruiting
StartedJanuary 30, 2023
Main results expectedJanuary 2029
Study endsJanuary 2029
Registry record updatedMay 29, 2025
Trial IDNCT04659824 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy men and women aged 18 to 95 who are French speakers and can provide informed consent.

Probably not a fit

Patients with neurological or psychiatric disorders, or those who have contraindications for MRI, are unlikely to benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between iron accumulation in the brain, as measured by MRI, and the age of healthy individuals. It will also explore how this iron load correlates with cognitive performance, various aging markers, and demographic factors. Participants will undergo MRI scans to assess their brain iron levels, and their cognitive abilities will be evaluated to understand potential impacts of iron accumulation on aging. The study focuses on a wide age range, from 18 to 95 years old, to capture a comprehensive view of healthy aging.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of brain health in aging and inform strategies to maintain cognitive function.

How similar studies have gone: While studies on brain iron accumulation exist, this specific approach focusing on healthy aging is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men or women between 18 and 95 years old
* French speaker with capability to understand the instructions
* Health insurance

Exclusion Criteria:

* Pregnancy
* minor subject
* no informed consent agreement
* subject enrolled in pharmaceutic study or exclusion period
* MRI contra-indications
* Neurological or psychiatric disorders
* MOCA \< 26
* Psychotropic drugs
* More than 3 MRI exams
* More than 1 neuropsychological assessment (same cognitive tests) in the last 12 months
* Unable to follow the entire protocol according to the investigator

Where it's running

  • Hopital Roger Salengro, CHU Lille
    Lille, France
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.