Examining iron levels in the brain during healthy aging
Official title: Study of Iron Accumulation Measured in MRI in Non-pathological Aging
Run by University Hospital, Lille · NCT04659824 · Data updated 2026-11-12
This study looks at how iron levels in the brain change as people age and whether this affects their thinking skills, involving healthy adults from 18 to 95 years old.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 95 Years |
| Sex | All |
| Enrollment | 190 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Status | Recruiting |
| Started | January 30, 2023 |
| Main results expected | January 2029 |
| Study ends | January 2029 |
| Registry record updated | May 29, 2025 |
| Trial ID | NCT04659824 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy men and women aged 18 to 95 who are French speakers and can provide informed consent.
✕Probably not a fit
Patients with neurological or psychiatric disorders, or those who have contraindications for MRI, are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the relationship between iron accumulation in the brain, as measured by MRI, and the age of healthy individuals. It will also explore how this iron load correlates with cognitive performance, various aging markers, and demographic factors. Participants will undergo MRI scans to assess their brain iron levels, and their cognitive abilities will be evaluated to understand potential impacts of iron accumulation on aging. The study focuses on a wide age range, from 18 to 95 years old, to capture a comprehensive view of healthy aging.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of brain health in aging and inform strategies to maintain cognitive function.
How similar studies have gone: While studies on brain iron accumulation exist, this specific approach focusing on healthy aging is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men or women between 18 and 95 years old * French speaker with capability to understand the instructions * Health insurance Exclusion Criteria: * Pregnancy * minor subject * no informed consent agreement * subject enrolled in pharmaceutic study or exclusion period * MRI contra-indications * Neurological or psychiatric disorders * MOCA \< 26 * Psychotropic drugs * More than 3 MRI exams * More than 1 neuropsychological assessment (same cognitive tests) in the last 12 months * Unable to follow the entire protocol according to the investigator
Where it's running
-
Hopital Roger Salengro, CHU Lille
Lille, France Recruiting
Study contacts
- Principal investigator: Grégory KUCHCINSKI, MD — University Hospital, Lille
- Study coordinator: Grégory KUCHCINSKI, MD
- Email: gregory.kuchcinski@chru-lille.fr
- Phone: 0320445962
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.