Nicotinamide Riboside and Exercise for Healthy Aging
Official title: Boosting the NAD+ Levels in Older Individuals Via Nicotinamide Riboside Supplementation and Exercise Training to Promote Metabolic Health
Run by Finis Terrae University · NCT06425042 · Data updated 2026-11-12
This study is testing if taking a supplement called nicotinamide riboside along with exercise can help older adults feel healthier and age better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years to 80 Years |
| Sex | All |
| Enrollment | 28 (estimated) |
| Sponsor | Finis Terrae University Academic / other |
| Locations | 1 site (Santiago, Santiago Metropolitan) |
| Status | Recruiting |
| Started | March 1, 2024 |
| Main results expected | December 2025 |
| Study ends | March 2026 |
| Registry record updated | July 11, 2025 |
| Trial ID | NCT06425042 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 60 to 80 with a BMI between 25 and 35 who can commit to the study requirements.
✕Probably not a fit
Patients with significant cardiovascular, liver, or kidney issues, or those with unstable body weight or engaging in excessive exercise may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of nicotinamide riboside (NR) supplementation combined with exercise training on promoting healthy aging and improving metabolic health in older adults. Participants aged 60 to 80 with a BMI between 25 and 35 will receive either NR or a placebo while engaging in a structured exercise program. The goal is to enhance mitochondrial function and energy metabolism, potentially mitigating age-related chronic diseases. The study aims to assess the impact of increased NAD+ levels on overall health and longevity.
Why it matters
Potential benefit: If successful, this approach could lead to improved metabolic health and reduced incidence of age-related chronic diseases in older adults.
How similar studies have gone: While the specific combination of NR supplementation and exercise is novel, previous studies have shown promising results with NAD+ precursors in improving metabolic health.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants are able to provide signed and dated written informed consent prior to any study specific procedures * Aged ≥ 60 and ≤ 80 years * Body mass index (BMI) 25 - 35 kg/m2 * Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months) * No signs of active cardiovascular disease, liver or kidney malfunction Exclusion Criteria: * Patients with congestive heart failure and and/or severe renal and or liver insufficiency * Uncontrolled hypertension * Any contra-indication for MRI scanning * Alcohol consumption of \> 3 servings per day for man and \>2 servings per day for woman * Smoking * Unstable body weight (weight gain or loss \> 5kg in the last 3 months) * Engagement in structured exercise activities \> 2 hours a week * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results * Use of food supplements containing NR or Resveratrol (similar working mechanisms)
Where it's running
-
Finis Terrae University
Santiago, Santiago Metropolitan, Chile Recruiting
Study contacts
- Study coordinator: Rodrigo Mancilla, PhD
- Email: rmancilla@uft.cl
- Phone: +56953676588
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.