Freeze-dried grape powder to support immune health in adults 50-75.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adults aged 50 to 75 will consume either a freeze-dried whole grape powder or a taste-matched control powder mixed with water each day while avoiding other polyphenol-rich foods. The study collects blood and related samples to measure markers of immune function, inflammation, and metabolism that are known to change with aging. People with major chronic illnesses, significant recent weight change, extreme BMI, or grape allergies are excluded to focus on healthy aging. The single-site intervention is conducted at the University of Connecticut Department of Nutritional Sciences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 50-75 years old (at time of screening)
* Body mass index (BMI) 18.5 to \< 30 kg/m2
* Willing to consume grape and control powder during study periods, and refrain from eating grapes and certain other polyphenol-rich foods and beverages during the study
* Do not fit any exclusion criteria

Exclusion Criteria:

* \<50 years old and \>75 years old
* BMI \<18.5 and ≥ 30 kg/m2 or body weight \< 110 pounds
* Experienced \>10% weight change in the past 4 weeks
* Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL
* Self-reported and/or physician-diagnosed history of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
* Allergy to grapes or any ingredients in the grape or control powders
* Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
* Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics in the last 3 months, active use of probiotics during the intervention
* Active smoker

Where it's running

• Department of Nutritional Sciences
  Storrs, Connecticut, United States Recruiting

Study contacts

• Study coordinator: Catherine J Andersen, PhD, RDN
• Email: catherine.andersen@uconn.edu
• Phone: 860-486-1704

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.