Freeze-dried grape powder to support immune health in adults 50-75.
Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
This will see if drinking a daily freeze-dried grape powder beverage changes immune, inflammation, and metabolism markers in healthy adults ages 50 to 75.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | University of Connecticut Academic / other |
| Locations | 1 site (Storrs, Connecticut) |
| Trial ID | NCT07079982 on ClinicalTrials.gov |
What this trial studies
Healthy adults aged 50 to 75 will consume either a freeze-dried whole grape powder or a taste-matched control powder mixed with water each day while avoiding other polyphenol-rich foods. The study collects blood and related samples to measure markers of immune function, inflammation, and metabolism that are known to change with aging. People with major chronic illnesses, significant recent weight change, extreme BMI, or grape allergies are excluded to focus on healthy aging. The single-site intervention is conducted at the University of Connecticut Department of Nutritional Sciences.
Who should consider this trial
Good fit: Ideal candidates are healthy adults 50-75 years old with a BMI between 18.5 and less than 30 who can follow dietary restrictions and consume the study powders daily.
Not a fit: People with diabetes, cardiovascular, liver or kidney disease, significant obesity or low body weight, pregnancy or lactation, or a grape allergy are unlikely to receive benefit from this protocol.
Why it matters
Potential benefit: If successful, this could offer a simple dietary approach to modestly improve immune markers and reduce age-related inflammation.
How similar studies have performed: Prior small human and animal studies of grape polyphenols have shown some favorable effects on inflammation and metabolic markers, but results in older healthy adults remain limited and not definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 50-75 years old (at time of screening) * Body mass index (BMI) 18.5 to \< 30 kg/m2 * Willing to consume grape and control powder during study periods, and refrain from eating grapes and certain other polyphenol-rich foods and beverages during the study * Do not fit any exclusion criteria Exclusion Criteria: * \<50 years old and \>75 years old * BMI \<18.5 and ≥ 30 kg/m2 or body weight \< 110 pounds * Experienced \>10% weight change in the past 4 weeks * Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL * Self-reported and/or physician-diagnosed history of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation * Allergy to grapes or any ingredients in the grape or control powders * Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance * Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics in the last 3 months, active use of probiotics during the intervention * Active smoker
Where this trial is running
Storrs, Connecticut
- Department of Nutritional Sciences — Storrs, Connecticut, United States (Recruiting)
Study contacts
- Study coordinator: Catherine J Andersen, PhD, RDN
- Email: catherine.andersen@uconn.edu
- Phone: 860-486-1704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.