Assessing gait and balance in rare neurological diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on individuals with rare and very rare neurological diseases, including conditions like multiple sclerosis and Parkinson's disease. It aims to evaluate gait and balance impairments that are common in these conditions, which can lead to increased fall risk and injuries. Participants will undergo assessments using questionnaires, clinical scales, and instrumental tests to gather essential data on their motor functions. The study seeks to improve understanding of these diseases, which are often poorly characterized due to their rarity.

Why it matters

Who can join: the full rules

Inclusion criteria

* Multiple sclerosis, Parkinson's disease, peripheral neuropathy of the lower limbs or rare or ultrarare neurological disease (e.g. la Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome - CANVAS, ORPHAcode: 504476; Wilson's disease, ORPHAcode: 905)
* undiagnosed neurological disease, i.e. a neurological disease that remains unknown after a full diagnostic assessment;
* age \> 18 years;
* ability to stand upright with no assistance and no assistive device for \> 30 seconds;
* ability to walk without assistance and with no assistive device for \> 50 m;
* ability to give their informed consent.

Exclusion criteria

* pregnancy or breastfeeding
* any other medical conditions affecting by itself balance and gait (e.g. lower limb amputation, hemiparesis due to a stroke)
* major orthopaedic surgery (e.g. hip or knee replacement).

Where it's running

• IRCCS Istituto Auxologico Italiano
  Milan, Milan, Italy Recruiting
• IRCCS Istituto Neurologico Carlo Besta
  Milan, Italy Active not recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.