Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses an adaptive computerized cognitive training program focused on executive functions to determine its effects in healthy older adults and individuals with mild cognitive impairment (MCI). Participants undergo training with the CogniFit platform and an active control with computer-based activities, assessing changes in executive function and potential transfer to memory, as well as emotional health, behavior, and quality of life. Recruitment occurs in Spain through day care centers and nursing homes, with older adults 65+ who do not have dementia. Outcomes include pre- and post-intervention differences in executive function, memory performance, emotional symptoms, behavioral disorders, and quality of life. Prior evidence on this topic is limited by small samples and short durations, making this study a meaningful step to understand potential broader benefits and applicability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adults 65 years of age and older;
2. spanish speakers;
3. residents in Spain (urban and rural communities);
4. elderly population that does not have dementia or other major diagnosed uncontrolled neurological disorders;
5. the initial cognitive state will be determined by a global screening test, the Lobo's Mini Cognitive Examination, that is, the spanish version of the Mini-Mental State Examination (MMSE); and 6) all participants must provide their signed written informed consent indicating that the individual has been informed of the relevant aspects of the study (and may withdraw from the study at any time if they so request).

Exclusion Criteria:

1. Older adults who obtain scores indicative of severe impairment (to be determined for low MEC scores that are suggestive of incipient dementia) or whose medical condition prevents them from participating safely;
2. diagnosis of dementia (e.g., Alzheimer's disease or other);
3. uncontrolled active major psychiatric illness (major depression, schizophrenia, etc.);
4. significant uncontrolled neurological conditions or history (e.g., Parkinson's disease, stroke, severe traumatic brain injury);
5. uncontrolled decompensated chronic medical conditions (e.g., diabetes, cardiovascular disease) that may affect cognition or attendance at sessions; and 6) severe uncorrected sensory disabilities (e.g., blindness or severe hearing loss) that interfere with the performance of tasks on tablets.

Where it's running

• Nebrija University
  Madrid, Madrid, Spain Recruiting
• Complutense University of Madrid
  Madrid, Madrid, Spain Recruiting

Study contacts

• Principal investigator: Víctor Echeverry-Alzate, PhD — Universidad Antonio de Nebrija
• Study coordinator: Víctor Echeverry-Alzate, PhD
• Email: vecheverry@nebrija.es
• Phone: +34 914 521 100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.