Longitudinal study on brain health and risk factors for neurological diseases
Official title: CUHK Brain Health Longitudinal Study
Run by Chinese University of Hong Kong · NCT03592563 · Data updated 2026-11-12
This study is trying to understand how different health factors affect brain health over time in people who are at risk for conditions like stroke and dementia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 5000 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 2 sites (Hong Kong and 1 other locations) |
| Status | Recruiting |
| Started | July 1, 2019 |
| Main results expected | December 31, 2038 |
| Study ends | December 31, 2048 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT03592563 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with established neurological or psychiatric conditions, those at high risk for such conditions, or individuals interested in maintaining brain health.
✕Probably not a fit
Patients without any neurological or psychiatric conditions and who are not interested in participating in longitudinal research may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to create a large cohort of individuals diagnosed with or at high risk for brain diseases, including stroke and dementia. Participants will complete the Neuro-QoL questionnaire to assess various aspects of their health and well-being. The study will gather data through medical records, questionnaires, and follow-up interviews to identify risk factors for neurological and psychiatric disorders over time. Ultimately, the goal is to develop scientifically validated strategies to promote and preserve brain health.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of brain health, potentially reducing the incidence of neurological diseases.
How similar studies have gone: Other studies focusing on longitudinal assessments of brain health have shown promise in identifying risk factors and improving patient outcomes, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
1. Adult ≥ 18 years of age
2. Fulfilling criteria for membership in one of these three groups:
* Red group: established diagnosis of one or more neurological and/or psychiatric conditions
* Yellow group: high-risk to develop one or more neurological and/or psychiatric conditions
1. family history (first degree relative) one or more neurological and/or psychiatric conditions
2. examination, imaging or laboratory findings consistent with pre-symptomatic stages of one or more neurological and/or psychiatric disorders
* Green group: not meeting criteria for Red or Yellow groups, but interested in longitudinal research on maintenance and/or improvement of brain health
3. Subject provides informed consent by signing and dating the written informed consent form
4. Subject is willing to answer health questionnaires and be followed longitudinally
Exclusion Criteria:
* None
Where it's running
-
Chinese University of Hong Kong
Hong Kong, Hong Kong Recruiting -
The Chinese University of Hong Kong
Hong Kong, Hong Kong Recruiting
Study contacts
- Principal investigator: Thomas Wai Hong LEUNG, FRCP — Division of Neurology, The Chinese University of Hong Kong
- Study coordinator: Thomas Wai Hong LEUNG, FRCP
- Email: drtleung@cuhk.edu.hk
- Phone: 852-35053593
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.