SHARP: Personalized Health and Behavior Plan to Lower Biological Age in Older Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study randomizes healthy community-dwelling adults over 50 to receive a personalized health and behavioral intervention based on an integrative systems approach, with biomarker and functional outcomes tracked at baseline, 6 months, and 12 months. Participants in the intervention group are guided by a tailored plan and monitored through a purpose-built app to track adherence and physiology. Comprehensive baseline and follow-up assessments include metabolic lab work, immune and hormonal panels, microbiome and proteomics analyses, physical and imaging measures, cognitive and mental health evaluations, and lifestyle data. Primary endpoints focus on changes in biological aging markers, while secondary endpoints assess functional and cognitive performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy older adults \>50 years old men and women

Exclusion Criteria:

1. A former diagnostic of a significant cognitive reduction (MoCa score \< 24 ).
2. Former diagnosis of neurodegenerative disease as Alzheimer's disease, Parkinson's disease, Lewy body dementia.
3. Former diagnosis of psychiatric disease.
4. In the past two years, underwent chemotherapy or radiation therapy.

Where it's running

• Sheba Medical Center
  Ramat Gan, Tel Aviv, Israel Recruiting

Study contacts

• Principal investigator: Evelyne Bischof, MD PhD — Sheba Medical Center
• Study coordinator: tzipi strauss, MD
• Email: zipora.strauss@sheba.heath.gov.il
• Phone: 972526664446

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.