Understanding how brain processes affect sentence production in people with aphasia
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
NA · University of Maryland, College Park · NCT06405594
This study is trying to understand how the brain works when people with post-stroke aphasia struggle to form sentences, in hopes of finding better ways to help them communicate.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 350 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Maryland, College Park (other) |
| Locations | 1 site (College Park, Maryland) |
| Trial ID | NCT06405594 on ClinicalTrials.gov |
What this trial studies
This research aims to explore the neurocognitive mechanisms behind sentence production impairments in individuals with post-stroke agrammatic aphasia. By investigating how lexical, grammatical, motoric, and cognitive processes interact during sentence production, the study seeks to identify the neural dynamics that contribute to communication difficulties. The findings could inform the development of more effective interventions for improving communication in individuals affected by aphasia. The study will involve both individuals with acquired aphasia and neurotypical adults to provide a comparative analysis.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with acquired aphasia following a left hemisphere brain injury, as well as neurotypical adults aged 18-30 or over 60.
Not a fit: Patients with prior neurological or psychiatric conditions or those who do not speak English fluently may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for individuals with aphasia, enhancing their communication abilities and overall quality of life.
How similar studies have performed: While there have been studies focusing on aphasia, this specific approach to understanding the neurocognitive mechanisms is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 18 years of age * Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke). * Neurotypical adults need to be either young (ages 18-30 years) or older (\> 60 years) * Native (or primary) speakers of English Exclusion Criteria: * Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia * do not speak English fluently
Where this trial is running
College Park, Maryland
- University of Maryland — College Park, Maryland, United States (RECRUITING)
Study contacts
- Principal investigator: Yasmeen Faroqi-Shah, PhD — University of Maryland
- Study coordinator: Yasmeen Faroqi-Shah, PhD
- Email: yfshah@umd.edu
- Phone: 3014054229
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aphasia, Acquired, Stroke, Healthy Aging