Understanding how brain processes affect sentence production in people with aphasia
Official title: Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
Run by University of Maryland, College Park · NCT06405594 · Data updated 2026-11-12
This study is trying to understand how the brain works when people with post-stroke aphasia struggle to form sentences, in hopes of finding better ways to help them communicate.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | University of Maryland, College Park Academic / other |
| Locations | 1 site (College Park, Maryland) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | June 2028 |
| Study ends | June 2029 |
| Registry record updated | September 3, 2024 |
| Trial ID | NCT06405594 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with acquired aphasia following a left hemisphere brain injury, as well as neurotypical adults aged 18-30 or over 60.
✕Probably not a fit
Patients with prior neurological or psychiatric conditions or those who do not speak English fluently may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to explore the neurocognitive mechanisms behind sentence production impairments in individuals with post-stroke agrammatic aphasia. By investigating how lexical, grammatical, motoric, and cognitive processes interact during sentence production, the study seeks to identify the neural dynamics that contribute to communication difficulties. The findings could inform the development of more effective interventions for improving communication in individuals affected by aphasia. The study will involve both individuals with acquired aphasia and neurotypical adults to provide a comparative analysis.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for individuals with aphasia, enhancing their communication abilities and overall quality of life.
How similar studies have gone: While there have been studies focusing on aphasia, this specific approach to understanding the neurocognitive mechanisms is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * At least 18 years of age * Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke). * Neurotypical adults need to be either young (ages 18-30 years) or older (\> 60 years) * Native (or primary) speakers of English Exclusion Criteria: * Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia * do not speak English fluently
Where it's running
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University of Maryland
College Park, Maryland, United States Recruiting
Study contacts
- Principal investigator: Yasmeen Faroqi-Shah, PhD — University of Maryland
- Study coordinator: Yasmeen Faroqi-Shah, PhD
- Email: yfshah@umd.edu
- Phone: 3014054229
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.