Correlating periostin levels with spinal degeneration in back pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the relationship between periostin expression in the intervertebral disc and Pfirrmann grading of disc degeneration in adults with chronic low back pain due to lumbar disc pathology. Participants are evaluated for lumbar conditions such as disc herniation or canal stenosis and undergo imaging and tissue assessment as available. The study uses surgical samples or imaging-based proxies to explore correlations with degeneration severity, without assigning a therapeutic intervention. No active treatment is tested; data collection focuses on understanding biological markers and imaging findings. Safety considerations align with standard care for participants undergoing routine procedures like posterior lumbar interbody fusion or lumbar discectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* lumbar disc herniation
* lumbar spinal canal stenosis
* patients who have MRI

Exclusion Criteria:

* allergic disease
* allergic rhinitis
* asthma
* atopic dermatitis
* chronic sinusitis
* history of cancer
* fracture within 6 months
* severe osteoporosis
* knee osteoarthritis
* hip osteoarthritis
* spinal surgery within 6 months
* myocardiac infarction
* heart failure
* liver cirrhosis

Where it's running

• Ji Hee
  Daegu, Daegu, South Korea Recruiting

Study contacts

• Study coordinator: JIHEE Hong
• Email: swon13@daum.net
• Phone: 01046794343

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.