Weight reduction program for chronic low-back pain

The Added Value of a Behavioral Weight Reduction Program to Blended Rehabilitation in Patients With Chronic Low Back Pain: A Randomized Clinical Trial

NA · Vrije Universiteit Brussel · NCT04824248

This study is testing if a weight loss program combined with pain education and exercise can help overweight people with chronic low back pain feel better.

Quick facts

PhaseNA
Study typeInterventional
Enrollment84 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorVrije Universiteit Brussel (other)
Locations2 sites (Brussels and 1 other locations)
Trial IDNCT04824248 on ClinicalTrials.gov

What this trial studies

This study recruits overweight or obese individuals aged 18 to 65 who suffer from chronic nonspecific low back pain. Participants will be randomly assigned to one of two groups for a 10-week intervention, combining online education and face-to-face sessions with a physical therapist. The experimental group will receive a behavioral weight reduction program alongside pain neuroscience education and cognition-targeted exercise therapy, while the control group will only receive pain education and exercise therapy. The primary outcome measured will be pain intensity, with secondary outcomes including body composition and physical activity levels.

Who should consider this trial

Good fit: Ideal candidates are overweight or obese individuals with chronic low back pain who are seeking care and can participate in a blended intervention format.

Not a fit: Patients with severe leg pain, specific spinal pathologies, or severe comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly reduce pain and improve quality of life for patients with chronic low back pain who are overweight or obese.

How similar studies have performed: Other studies have shown promising results with similar approaches combining weight management and pain education, suggesting potential for success in this trial.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Overweight (BMI ≥ 25 kg/m2) or obese (BMI ≥ 30 kg/m2) with chronic low back pain
* Non-specific low back pain for at least 3 months' duration
* Currently seeking care for low back pain
* Native Dutch speaker
* Access to internet and computer/tablet/smartphone

Exclusion Criteria:

* Leg pain of 7 or higher (on a maximum of 10) on a numeric rating scale
* Evidence of specific spinal pathology (e.g., hernia, spinal stenosis, spondylolisthesis, infection, spinal fracture or malignancy)
* Evidence of a severe underlying comorbidity (e.g. diabetes, cardiovascular problems, metabolic diseases)
* BMI ≥ 40 kg/m2
* Being pregnant or given birth in the preceding year
* Currently receiving dietary or exercise interventions

Where this trial is running

Brussels and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Chronic Low-back Pain, Overweight or Obesity, chronic low back pain, chronic pain, physiotherapy, physical therapy, weight reduction, pain management

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.