Condition

Arthritis clinical trials and research

• 23Clinical trials
• 198NIH research projects
• 10Countries

Newest Arthritis clinical trials

All recruiting trials (23)

• Pain patterns in rheumatic diseases: see if pain works differently in patients and healthy people

  This observational study tests how pain is experienced and measured in people with rheumatic diseases compared with healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07829497

• Ultrasound Before Corticosteroid Injection for Arthritis

  This trial tests whether applying ultrasound before a corticosteroid joint injection helps improve arthritis symptoms in adults with limb arthritis who need an injection.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT07363876

• Ultralow-dose PET scan to detect bone activity with 18F‑NaF

  This trial tests whether a new high-sensitivity PET scan using a tiny amount of 18F‑sodium fluoride can produce clear bone images in adults with or without bone disease while cutting radiation exposure by 10–100 times.

  Recruiting Phase 2 Nuclear Imaging Institute · Englewood, New Jersey and 1 other locations · NCT07284563

• Early stratification of acute arthritis

  The project will collect clinical information and biomarker samples to try to find signs that help classify and guide treatment for adults who developed inflammatory arthritis symptoms within the past 12 weeks.

  Recruiting Diakonhjemmet Hospital · Oslo · NCT07106931

• Biophoton therapy for chronic severe arthritis pain relief

  This study is testing if biophoton therapy can help people with chronic severe arthritis pain feel better over 12 weeks.

  Recruiting First Institute of All Medicines · Butler, Pennsylvania · NCT06915012

• Examining the effects of different exercise levels on arthritis symptoms

  This study tests how different amounts of exercise can help people with arthritis feel better over six months.

  Recruiting University of South Carolina · Columbia, South Carolina · NCT06880653

• Understanding pain in inflammatory joint diseases

  This project will follow people with inflammatory joint diseases who are starting or switching biological or targeted synthetic DMARDs to try to identify different pain types and see if central sensitization and cognitive function relate to persistent pain.

  Recruiting Diakonhjemmet Hospital · Oslo · NCT06718569

• Exercise therapy for people with axial spondyloarthritis

  This study is testing if a 12-week home-based walking program can help people with axial spondyloarthritis feel better and improve their overall health while they are already on medication.

  Recruiting at 2 sites Loughborough University · Loughborough, Leicestershire and 1 other locations · NCT06669702

• Understanding the impact of immune-related side effects in arthritis patients after immunotherapy

  This study looks at how immune-related side effects from immunotherapy affect the daily lives of arthritis patients and what they think about these experiences.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06647134

• Fecal microbiota transplantation for treating axial spondyloarthritis

  This study is testing if a treatment using gut bacteria from healthy donors can help people with axial spondyloarthritis who aren't feeling better with their current medications.

  Recruiting Phase 2 University Hospital of North Norway · Tromsø · NCT06451588

• Aptis PRUJ prosthesis to restore motion and stability of the proximal radioulnar joint

  This trial will test whether the Aptis PRUJ prosthesis helps adults with painful, unstable proximal radioulnar joints regain stability and forearm motion.

  Recruiting at 6 sites Aptis Medical · Carmel, Indiana and 6 other locations · NCT05796908

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Hydrogel coating to prevent infections after hip surgery

  This study is testing whether a special hydrogel coating can help prevent infections after hip surgery for people getting a new hip implant.

  Recruiting Medacta International SA · Vienna · NCT05679232

• Telehealth exercise program for Veterans with arthritis

  This study tests a telehealth exercise program for Veterans with arthritis to see if it helps them stay active and satisfied with their care.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT05666167

• Dapansutrile tablets for treating acute gout flares

  This study is testing if dapansutrile tablets can help people with acute gout flares feel better compared to a placebo.

  Recruiting at 30 sites Phase 2/3 Olatec Therapeutics, Inc. · Birmingham, Alabama and 39 other locations · NCT05658575

• Comparing two surgical treatments for CMC arthritis

  This study is testing two different surgical options for people with CMC arthritis to see which one helps relieve pain better and gets them back to their normal activities faster.

  Recruiting at 2 sites Fraser Orthopaedic Research Society · Calgary, Alberta and 1 other locations · NCT05111405

• Exploring the Benefits of Natural Medicine and Vitamin IV Therapy

  This study is testing whether herbal medicine and vitamin IV therapy can help improve health and manage chronic conditions like anxiety, fibromyalgia, and arthritis.

  Recruiting The Essence of Integrative Health and Medicine Practice · Dover, Delaware · NCT05067998

• Comparing two techniques for wrist fusion in patients with post-traumatic arthritis

  This study is testing two different surgery techniques for wrist fusion to see which one helps adults with post-traumatic arthritis feel better and regain more movement in their wrists.

  Recruiting at 5 sites University of Alberta · Calgary, Alberta and 4 other locations · NCT04580225

• Comparing hydroxychloroquine and prednisone for joint pain in cancer patients

  This study is testing whether adding hydroxychloroquine to prednisone can help cancer patients with joint pain from their treatment feel better than using prednisone alone.

  Recruiting Phase 2 AHS Cancer Control Alberta · Edmonton, Alberta · NCT04354649

• Understanding the causes and effects of systemic juvenile idiopathic arthritis and adult-onset Still's disease

  This study is trying to understand what causes systemic juvenile idiopathic arthritis and adult-onset Still's disease by looking at the health history and genetics of children and adults with these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03510442

• Understanding the natural progression of spondyloarthritis

  This study looks at how spondyloarthritis develops over time in both kids and adults to see if certain signs can help predict who might get more severe symptoms later on.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01422694

• Collection of synovial fluid from arthritis patients

  This study is collecting joint fluid and blood samples from arthritis patients to see if new markers can help us understand joint damage and inflammation better.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT00512343

• Exploring the causes of rheumatic diseases in minority communities

  This study looks at the causes and effects of rheumatic diseases in minority communities to better understand health differences and improve care for those affected.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00024479

NIH-funded research (newest 40 of 198)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Gut microbes and methotrexate: boosting RA treatment through microbiome targets

  Researchers are studying how gut bacteria affect how well methotrexate works for people with rheumatoid arthritis, aiming to make MTX effective for more patients.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11606746

• Understanding how immune checkpoint drugs can trigger inflammatory arthritis in cancer patients

  This research looks at why some cancer patients develop inflammatory arthritis after PD-1 inhibitor therapy and what could be done to prevent it.

  NIH research Yale University · New Haven, United States · NIH-11603643

• Hybrid biomaterial system to boost immunotherapy for rheumatoid arthritis

  A new, patient-facing immunotherapy approach uses specialized particles to retrain the immune system to calm RA in adults.

  NIH research University of Florida · Gainesville, United States · NIH-11552872

• Dose guide for physical activity to improve arthritis symptoms

  A study from the University of South Carolina will look at how different amounts of weekly physical activity affect arthritis symptoms and quality of life in adults with arthritis.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11503934

• Collaborating Center for Arthritis Care Tools and a Coordinating Center for an Arthritis Management & Wellbeing Network

  A coordinated NIH program aims to improve how primary care providers refer people with arthritis to evidence-based, self-management programs and to boost participation, especially among groups facing disparities.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11503933

• Arthritis prevention program to help adults with OA in mountain west communities

  A program to help adults with osteoarthritis in the Mountain West connect with physical activity counseling and community activities to reduce activity limitations.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11503932

• Pathways to arthritis flare persistence via resident memory T cells

  A study to understand how memory T cells in joints keep rheumatoid arthritis and juvenile arthritis flares going, with the goal of new therapies.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11460307

• Understanding how mutations in MIF may drive inflammatory arthritis in kids

  A kid-focused look at how changes in a protein called MIF could cause systemic juvenile idiopathic arthritis and what this could mean for better treatments.

  NIH research Yale University · New Haven, United States · NIH-11454897

• Role of Stabilin receptors in rheumatoid arthritis

  A short study to understand how certain scavenger receptors may influence the development and progression of rheumatoid arthritis in adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11453262

• Antenatal DMARD Use and Mother-Child Health in Women with Chronic Inflammatory Arthritis

  This project aims to understand how continuing pregnancy-safe arthritis medicines during pregnancy affects health outcomes for mothers with chronic inflammatory arthritis and their babies.

  NIH research Yale University · New Haven, United States · NIH-11452559

• IgG glycosylation and endothelial FcγRIIB: understanding RA-related heart and blood vessel disease

  This project looks at how rheumatoid arthritis affects blood vessels and clotting, with the goal of uncovering new ways to prevent heart and stroke risk for people with RA.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11448488

• Risk factors and biomarkers for progression of subclinical RA-related lung disease

  This study follows people with rheumatoid arthritis to understand who develops lung disease and what biomarkers predict it.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11447980

• Deciphering What Drives Juvenile Idiopathic Arthritis in African American Children

  This project looks at why African American children with juvenile idiopathic arthritis have more joint damage, using clinical data and genetic information to find factors that may explain the differences.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11442239

• Gut barrier and antibiotics: how gut health affects inflammatory arthritis

  Antibiotic use may increase the risk of inflammatory arthritis by changing the gut, and this project looks at how those gut changes influence joint inflammation in people with arthritis.

  NIH research Washington University · Saint Louis, United States · NIH-11417167

• ctDNA biomarker to guide safety of cancer immunotherapy in inflammatory arthritis

  A patient-facing biomarker study using a blood test to detect tumor DNA in people with cancer who develop inflammatory arthritis from immunotherapy, to help doctors pick safer treatment choices.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11411495

• Pregnancy changes in rheumatoid arthritis and new treatment ideas

  This research seeks to understand why some women’s rheumatoid arthritis improves during pregnancy and how to predict and mimic that effect to make treatments safer and more effective for pregnant patients.

  NIH research Northwestern University · Chicago, United States · NIH-11404945

• FRAX fracture risk in rheumatoid arthritis patients 65 and older

  This grant tests how well the FRAX fracture risk tool predicts fractures in people with rheumatoid arthritis who are 65 and older.

  NIH research Augusta University · Augusta, United States · NIH-11404833

• Population-Based RA Outcomes in Rural America

  A Mayo Clinic-led study is using AI to spot rheumatoid arthritis earlier and reduce delays in treatment for people living in rural areas.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11401420

• Neuroimaging markers that link stress with RA-related inflammation and response to therapy

  Scientists will look at brain activity and imaging markers to understand how stress and mood relate to inflammation in rheumatoid arthritis and how this affects treatment response.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11399705

• Setbp1’s role in how joint cells behave during inflammatory arthritis

  This project looks at how a protein called SETBP1 affects delicate joint cells (FLS) that drive inflammation in arthritis, with potential implications for better treatments.

  NIH research Emory University · Atlanta, United States · NIH-11398188

• How genetic clues help understand juvenile arthritis in kids

  Researchers are studying how genetic differences raise the risk of juvenile arthritis by looking at the ways genes are turned on or off in immune cells.

  NIH research University of Washington · Seattle, United States · NIH-11396512

• INPP5E Signaling and Treatment in Rheumatoid Arthritis

  This project explores how a specific molecule, INPP5E, affects inflammation in rheumatoid arthritis and whether it could become a new treatment option.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11393647

• Deciphering how complement signals shape macrophages in autoimmune arthritis

  A study with RA patients aims to learn how different immune cells in joints interact with complement signals to find new ways to tailor treatments.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11392260

• Understanding how T cells make IFN-γ and IL-17 in kids with juvenile arthritis

  A doctor-scientist at Vanderbilt is studying why certain immune cells in children with juvenile idiopathic arthritis produce inflammatory signals, with the goal of improving diagnosis and treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11392245

• Granzyme K+ CD8 T cells in rheumatoid arthritis joints

  A study exploring how a special type of immune cell behaves in the inflamed joints of people with rheumatoid arthritis and how it may drive inflammation.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11389141

• Obesity-related inflammatory signals predicting treatment response in rheumatoid arthritis patients starting biologics

  This study looks at whether inflammatory markers tied to obesity can predict which RA patients will respond poorly to new biologic therapies.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11387816

• Immunotherapy using a probiotic-based treatment for rheumatoid arthritis

  A small, probiotic-based therapy taken by mouth aims to calm the immune system in people with rheumatoid arthritis to reduce joint inflammation.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11385365

• Engineered cells that repair arthritis using disease-aware signals

  A research grant seeks to use specially designed cells that sense damaged joint environments and deliver regenerative therapy for arthritis, with the goal of improving cartilage and joint health.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11384709

• Bacteria-made indoles and inflammatory arthritis

  A study from the University of Colorado Denver is looking at how gut bacteria convert tryptophan into indoles that may drive inflammatory arthritis in people.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11380536

• Granzyme K–expressing CD8 T cells in rheumatoid arthritis joints

  A five-year study will explore how granzyme K–producing CD8 T cells behave in inflamed joints of people with rheumatoid arthritis and what that means for disease progression and treatment.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11380025

• Decoding T cell targets in rheumatoid arthritis for better treatments

  Aiming to identify what specific targets in the immune system trigger autoimmune T cells in rheumatoid arthritis, with the goal of guiding more precise therapies.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11378310

• Th17 cell plasticity and its role in rheumatoid arthritis

  This grant looks at how a type of immune cell called Th17 might change form and keep rheumatoid arthritis inflammation, even when we try to block a key molecule they make.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11376756

• Role of the CD47 Pathway in Rheumatoid Arthritis

  A study to understand how the CD47 pathway affects rheumatoid arthritis and whether blocking CD47 can improve joint inflammation and bone damage.

  NIH research University of Rochester · Rochester, United States · NIH-11374511

• Precision monitoring of Psoriatic Arthritis treatment using at-home RNA sampling and smartphone data

  A new study will track how Psoriatic Arthritis patients respond to TNF-inhibitor therapy using at-home RNA sampling and a remote smartphone app to collect data.

  NIH research New York University School of Medicine · New York, United States · NIH-11374491

• Type I interferon and treatment response in rheumatoid arthritis

  A doctor-scientist team is studying how a specific immune signal, type I interferon, affects which rheumatoid arthritis treatments work best for patients.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11369114

• PROACTIVE: Tailored pain relief for musculoskeletal and arthritis-related movement pain

  A tailored pain self-management program offering education, a resource toolkit, active prayer, and financial counseling for adults with chronic movement-related musculoskeletal pain.

  NIH research University of Florida · Gainesville, United States · NIH-11369050

• Understanding immune-triggered inflammatory arthritis from cancer immunotherapy

  A clinical study looks at why inflammatory arthritis caused by cancer immunotherapy affects people differently and how to best treat it.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365141

• How nerves and immune cells cause joint pain in rheumatoid arthritis

  Researchers will map how sensory nerves and immune cells in joints interact in people with rheumatoid arthritis to point toward new ways to reduce pain and inflammation.

  NIH research University of Washington · Seattle, United States · NIH-11363978

• Complement system’s role in autoimmune arthritis

  A research grant explores how a part of the immune system called complement drives inflammatory arthritis and what happens when it’s made locally in joint tissue.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11361363

• Lyme arthritis: how joint immune cells switch from protectors to attackers

  A doctor-researcher at the University of Iowa is studying why Lyme arthritis sometimes becomes a long-lasting inflammatory problem and how protective joint immune cells may turn inflammatory during infection.

  NIH research University of Iowa · Iowa City, United States · NIH-11357658

Related topics

Quick answers

How many Arthritis clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (13 trials), Canada (4 trials), Norway (3 trials), France (1 trial), Israel (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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