NIH-funded research Sbir 2 grant

Using virtual reality therapy to reduce chronic low back pain

Official title: Efficacy of a Virtual Reality Neuroscience-based Therapy for Chronic Low Back Pain

Funded at Cognifisense, INC. · NIH-11112333 · Data updated 2026-11-12

This study is testing a new virtual reality therapy that helps people with chronic low back pain by using fun and immersive experiences to change how their brain processes pain, and it's looking for participants to see if this therapy works better than regular treatments.

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionCognifisense, INC.
NIH-funded
Lab location1 site (Sunnyvale, United States)
Project startSeptember 23, 2019
Project endApril 30, 2027
Funding year2025
Award (this year)$580,584
NIH project number5R44NR017575-03
Project IDNIH-11112333 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults aged 21 and older who experience chronic low back pain.

Less likely to help

Patients with acute pain or those who do not have chronic low back pain may not benefit from this research.

What this research studies

This research investigates a novel virtual reality therapy designed to alleviate chronic low back pain by addressing the underlying neurological factors that contribute to pain perception. The therapy, known as Virtual Reality Neuroscience-based Therapy (VRNT), aims to create lasting pain relief through immersive experiences that target the brain's pain processing pathways. Participants will engage in a randomized controlled trial to evaluate the effectiveness of this therapy compared to standard treatments, with the goal of making the VRNT system available for broader use. The study builds on promising results from earlier phases, focusing on a comprehensive approach to pain management.

Why it matters

Potential benefit: If successful, this research could provide a new, effective treatment option for individuals suffering from chronic low back pain, potentially reducing reliance on medications.

How similar studies have gone: Previous clinical trials have shown success with similar virtual reality approaches in pain management, indicating a promising avenue for treatment.

Where this research is happening

  • Cognifisense, INC.
    Sunnyvale, United States
    Active

Researchers

  • Principal investigator: Way, Amanda — Cognifisense, INC.
  • Study coordinator: Way, Amanda

Related research

Other NIH-funded projects on the same topics.

  • Virtual reality program to reduce chronic low back pain

    This project will see if a virtual-reality, brain-targeting treatment can reduce long-term low back pain in adults.

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  • Using virtual reality to enhance acupuncture treatment for chronic low back pain

    This study is exploring a new way to help people with chronic low back pain by using virtual reality to create an acupuncture experience in their minds, which might help those who haven't found relief with regular treatments.

    NIH research Massachusetts Neuro Technology, INC. · Weston, United States · NIH-10976167

  • Using virtual reality to help manage chronic low back pain

    This study is exploring how virtual reality can help adults with chronic low back pain feel better and move more, comparing it to regular pain treatments to see which works best for improving their daily lives.

    NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10896861

  • Using virtual reality to enhance acupuncture treatment for chronic low back pain

    This study is exploring a new way to help people with chronic low back pain by using virtual reality to create an acupuncture experience in their minds, which might help reduce their pain and improve their daily life.

    NIH research Massachusetts Neuro Technology, INC. · Weston, United States · NIH-10695389

  • Using virtual reality to help manage chronic low back pain

    This study is exploring whether using virtual reality can help adults with chronic low back pain feel better and move more easily, comparing it to regular pain treatments like opioids, so you can see if this fun new approach might work for you!

    NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10683125

  • Ketamine-assisted care plan to help Veterans with chronic back pain and depression

    A program for Veterans with chronic low back pain and depression that uses ketamine infusions followed by a brief narrative therapy to sustain relief from pain and mood improvement.

    NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11533116

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.