Condition

Chronic Migraine clinical trials and research

• 24Clinical trials
• 2NIH research projects
• 20Countries

Newest Chronic Migraine clinical trials

All recruiting trials (24)

• Nebulized dexmedetomidine for early chronic migraine

  This study tests whether inhaled dexmedetomidine can lessen central sensitization and help prevent chronification in people with early chronic migraine.

  Recruiting Beni-Suef University · Banī Suwayf · NCT07769255

• i-NEED: New migraine drugs database

  This project will collect real-life data to see how new migraine treatments—anti‑CGRP antibodies, gepants, ditans, and a sumatriptan‑naproxen combo—work and how well adults with episodic or chronic migraine tolerate them.

  Recruiting at 2 sites IRCCS San Raffaele Roma · Milan, Italy and 1 other locations · NCT07103694

• Suppressive Functions of Regulatory T Cells in Migraine

  This study tests whether regulatory T cells can help control migraine-related inflammation in adults with chronic migraine.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07067112

• Comparing sphenopalatine block and BOTOX for chronic migraine relief

  This study is testing whether a nerve block or BOTOX injections can help people with chronic migraines feel better.

  Recruiting Cairo University · Cairo · NCT06974617

• Using Atogepant tablets to prevent migraines in teens aged 12 to 17

  This study is testing if Atogepant tablets can help prevent migraines in teenagers aged 12 to 17.

  Recruiting at 61 sites Phase 3 AbbVie · Huntsville, Alabama and 65 other locations · NCT06810505

• Acceptance and Commitment Therapy to reduce disability in adults with chronic migraine

  This trial will test whether adding Acceptance and Commitment Therapy (ACT) to usual care helps adults with chronic migraine improve daily functioning and reduce headache frequency and pain.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06795867

• Comparing nerve block injections to Botox for chronic migraine relief

  This study tests whether nerve block injections or Botox can help adults with chronic migraines feel better and have fewer migraine days.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684249

• Assessing the safety and effectiveness of Atogepant for migraine prevention in Korean adults

  This study is testing how well and safely Atogepant works for preventing migraines in Korean adults who have chronic or episodic migraines.

  Recruiting at 36 sites AbbVie · Busan, Busan Gwang Yeogsi and 35 other locations · NCT06603558

• Using Atorvastatin to prevent chronic migraines

  This study is testing if taking Atorvastatin every day can help prevent chronic migraines for people who suffer from them.

  Recruiting at 3 sites Phase 2 St. Olavs Hospital · Bergen and 5 other locations · NCT06485336

• Evaluating the PRIMUS System for treating resistant migraines

  This study tests a new device called the PRIMUS System to see if it can help people with chronic migraines who haven't found relief from other treatments.

  Recruiting at 8 sites Salvia BioElectronics · Broadmeadow, New South Wales and 10 other locations · NCT06450444

• Using ultrasound to block a nerve for treating chronic migraines

  This study is testing if using ultrasound to block a specific nerve can help adults with chronic migraines who haven't found relief from regular treatments.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06322407

• Evaluating the ketogenic diet's effects on children with various conditions

  This study is testing if the ketogenic diet can help children with conditions like epilepsy, autism, migraines, and brain tumors feel better and grow properly.

  Recruiting at 3 sites Danone Nutricia SpA Società Benefit · Milan, MI and 2 other locations · NCT06309251

• Using laser acupuncture to help prevent chronic migraines

  This study is testing if laser acupuncture can help people with chronic migraines have fewer headache days and feel better overall.

  Recruiting Taichung Veterans General Hospital · Taichung, Xitun District · NCT06219694

• Evaluating the effectiveness of rimegepant for treating migraines

  This study tests if a new migraine pill called rimegepant can help people with migraines feel better during their attacks and how well they can handle any side effects.

  Recruiting at 2 sites University of Florence · Florence and 1 other locations · NCT05903027

• Comparing telehealth cognitive behavioral therapy for youth with migraines

  This study is testing whether online therapy for kids and teens with migraines works better when combined with medication or on its own.

  Recruiting at 15 sites Children's Hospital Medical Center, Cincinnati · Birmingham, Alabama and 14 other locations · NCT05889624

• Non-invasive brain stimulation for chronic migraine relief

  This study is testing whether a type of brain stimulation can help people with chronic migraines feel better compared to a fake treatment.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05769348

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Comparing BOTOX® and XEOMIN® for treating chronic migraine

  This study is testing whether BOTOX® or XEOMIN® can help active duty military personnel and their families reduce the number of chronic migraine headaches they experience.

  Recruiting Phase 3 Naval Medical Center Camp Lejeune · Jacksonville, North Carolina · NCT05598723

• Evaluating a lifestyle intervention for chronic migraine management

  This study is testing a new lifestyle program to see if it can help people with chronic migraines feel better compared to a control group.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05415020

• Using cannabis to treat chronic headaches in teenagers

  This study is testing if a special cannabis extract can help teenagers aged 14 to 17 with chronic headaches feel better and manage their pain.

  Recruiting Phase 2 University of Manitoba · Vancouver, British Columbia and 2 other locations · NCT05337033

• Understanding how CGRP affects autonomic function in migraine patients

  This study is trying to see how a migraine treatment affects the nervous system in people with migraines, both during attacks and when they're feeling fine.

  Recruiting Medical University of Vienna · Vienna · NCT04628429

• Cannabidiol (CBD) to prevent chronic migraine

  This trial will test whether a daily cannabidiol (CBD) pill can reduce headaches in adults with chronic migraine.

  Recruiting Phase 2 University of Calgary · Calgary, Alberta · NCT03972124

• Treatment of chronic migraine with Well-Being Therapy

  This study is testing if Well-Being Therapy can help people with chronic migraines feel better and improve their mental health.

  Recruiting University of Florence · Florence, Florence and 1 other locations · NCT03404336

• Understanding why some headaches become chronic

  This study is trying to find out why some people’s headaches turn into chronic ones by looking at different factors like brain function and genetics.

  Recruiting Stanford University · Stanford, California · NCT03231241

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Testing a new approach to manage chronic migraine through lifestyle changes

  This study is looking at how making healthy lifestyle changes, like exercising regularly and improving sleep, can help people with chronic migraines feel better without using medication.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11159272

• Investigating the role of a specific receptor in chronic migraine

  This study is looking at how a specific receptor in the brain might play a role in chronic migraines, using animal models to see what happens when this receptor is missing, with the hope of finding new ways to help people who suffer from migraines.

  NIH research Florida Atlantic University · Boca Raton, United States · NIH-10845955

Related topics

Quick answers

How many Chronic Migraine clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (8 trials), Italy (5 trials), Canada (3 trials), Egypt (3 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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