Condition

Back Pain clinical trials and research

• 24Clinical trials
• 120NIH research projects
• 12Countries

Newest Back Pain clinical trials

All recruiting trials (24)

• ESPB for persistent back pain in ankylosing spondylitis

  This trial tests whether an erector spinae plane block can help reduce persistent back pain in adults with ankylosing spondylitis who still have pain despite controlled disease activity.

  Recruiting Marmara University · Istanbul, Pendik · NCT07633730

• Erector Spinae Plane Block vs Trigger Point Injection for Chronic Thoracic Myofascial Pain

  A randomized trial tests whether an erector spinae plane (ESP) block or a trigger point injection (TPI) provides better relief for adults with chronic thoracic myofascial pain.

  Recruiting Phase 4 Mayo Clinic · Jacksonville, Florida and 4 other locations · NCT07632820

• Transcutaneous Electrical Nerve Stimulation for Acute Low Back Pain in EDs

  This trial tests whether TENS can relieve acute low back pain in adults who come to the emergency department.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT07588490

• Hormones, Pain, and Exercise: Sports Bras for Full-Busted Women

  This study tests whether specially designed sports bras can reduce neck, shoulder, arm, and back pain in full-busted women, and whether hormones, inflammation, or brain changes affect pain.

  Recruiting Phase 1 University of Houston · Houston, Texas · NCT07579182

• Mindfulness-based stress reduction for chronic thoracic or lumbar back pain

  This project will test whether an 8-week mindfulness-based stress reduction (MBSR) course helps working-age adults (18–64) with chronic thoracic or lumbar back pain reduce their pain compared with usual care.

  Recruiting at 4 sites Tampere University Hospital · Tampere and 3 other locations · NCT07528833

• Pulsed vs Conventional Radiofrequency for Tailbone Pain

  This study tests whether pulsed or conventional radiofrequency ablation of the ganglion impar better relieves tailbone (coccydynia) pain and improves sleep and quality of life in adults who have not responded to other treatments.

  Recruiting at 2 sites Adana City Training and Research Hospital · Adana, Adana and 1 other locations · NCT07497269

• Psychological Options for Wellness and Recovery (POWeR) for Veterans with Chronic Back or Neck Pain

  This study tests whether Pain Reprocessing Therapy (PRT), cognitive behavioral therapy (CBT), or usual care works best to lower pain in veterans with chronic back or neck pain.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07137715

• Three dry needling approaches for chronic low back pain

  This study will see if three types of dry needling—dry needling alone, dry needling with high-rate PENS, and dry needling with low-rate PENS—reduce pain and improve quality of life for adults with chronic low back pain.

  Recruiting The University of Texas Medical Branch, Galveston · Galveston, Texas · NCT07112404

• Cultural adaptation and validation of a pain questionnaire in Turkish

  This study is testing a new version of a pain questionnaire for Turkish-speaking people with chronic pain conditions like osteoarthritis, back pain, and fibromyalgia to see if it accurately reflects their experiences.

  Recruiting Hacettepe University · Ankara, Altındağ · NCT06825650

• Consultation with a radiologist before spinal injections

  This study is testing if having a chat with a radiologist before spinal injections can help patients feel less anxious and have a better overall experience.

  Recruiting University Hospital, Montpellier · Montpellier, Occitnaie · NCT06762665

• Using Electroacupuncture and Dry Cupping to Treat Back Pain from Lumbar Spondylosis

  This study is testing if a combination of Electroacupuncture and Dry Cupping can help relieve back pain for people with lumbar spondylosis.

  Recruiting University of Medicine and Pharmacy at Ho Chi Minh City · Ho Chi Minh City · NCT06693453

• Multidisciplinary treatment for chronic low back pain

  This study is testing a new program that combines education, therapy, and exercise to see if it can help people with chronic low back pain feel better and improve their quality of life compared to regular treatment.

  Recruiting University of Barcelona · Barcelona, Barcelona and 1 other locations · NCT06679205

• Using the medidux smartphone app to manage discharge from the Acute Admission Unit

  We will test whether adults discharged from the Acute Admission Unit with cough, back pain, or abdominal discomfort who use the medidux app are less likely to return or need extra medical visits within 7 days.

  Recruiting Mobile Health AG · Horgen, Canton of Zurich · NCT06655337

• Understanding multiple health issues in patients with spinal pain

  This study looks at how common it is for people with back and neck pain to have other health issues and how these affect their treatment and recovery.

  Recruiting Aalborg University Hospital · Aalborg · NCT06402409

• Using Haloperidol to Manage Acute Back Pain in the Emergency Department

  This study is testing whether Haloperidol can help relieve acute back pain in adults who come to the emergency department, comparing it to a common pain medication.

  Recruiting Phase 4 Western Michigan University School of Medicine · Kalamazoo, Michigan · NCT06395428

• Managing Low Back Pain for Horticulture Workers

  This study is testing two different ways to help nursery and landscape workers manage their low back pain, one with extra personalized support and the other with just self-management videos, to see which works better.

  Recruiting University of Florida · Gainesville, Florida · NCT06153199

• CARES: Comprehensive Analgesic, Recovery, and Education Support for Surgery

  This trial tests whether combining motivational interviewing–guided opioid tapering with the medication tizanidine helps adults who used opioids long-term before elective surgery stop or return to their pre-surgery opioid levels sooner and recover from pain faster than enhanced usual care.

  Recruiting at 4 sites Phase 3 Stanford University · Stanford, California and 3 other locations · NCT06027099

• Evaluating Alocyte for treating facet joint back pain

  This study is testing a new treatment called Alocyte to see if it can help people with chronic back pain from facet joints who haven't found relief from other treatments.

  Recruiting Phase 1 The Center For Regenerative Medicine Laboratories · North Miami, Florida · NCT05909709

• Oral cannabis for chronic neck and back pain

  This trial will test whether a daily oral cannabis solution can reduce spine pain and help people with chronic back or neck pain lower their high-dose opioid use.

  Recruiting Phase 3 University of Colorado, Denver · Aurora, Colorado · NCT05052541

• Comparing high-intensity and moderate-intensity exercise during pregnancy and its effects on health and birth outcomes

  This study tests whether high-intensity or moderate-intensity exercise during pregnancy can improve health and birth outcomes for moms and their babies.

  Recruiting Gdansk University of Physical Education and Sport · Gdansk, Pomeranian Voivodeship · NCT05009433

• Investigating how cannabis helps relieve pain

  This study is testing how vaporized cannabis helps relieve pain by looking at how it affects the brain while participants feel controlled heat.

  Recruiting Early Phase 1 University of California, San Diego · La Jolla, California · NCT04982965

• Preventing neck and back pain in teleworking office workers

  This study is testing whether a training program and educational video can help office workers who work from home avoid neck and back pain over 12 weeks.

  Recruiting University Ghent · Ghent, East Flanders · NCT04783454

• Impact of muscle degeneration on chronic low back pain after surgery

  This study looks at how muscle loss affects ongoing back pain in people who have surgery for spine problems, to help improve recovery and predict results.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT04273828

• Neck and low back pain among medical students at UWI Mona

  This project will test whether a standardised spine exercise program helps medical students at UWI Mona who have neck or low back pain while also measuring how common these pains are and students' spine-health knowledge.

  Recruiting The University of The West Indies · Kingston, Kingston and 1 other locations · NCT03707288

NIH-funded research (newest 40 of 120)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ketamine-assisted care plan to help Veterans with chronic back pain and depression

  A program for Veterans with chronic low back pain and depression that uses ketamine infusions followed by a brief narrative therapy to sustain relief from pain and mood improvement.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11533116

• Savoring Meditation for Chronic Low Back Pain patients

  A study tests a brief mindfulness-based practice called Savoring Meditation to help people with chronic low back pain feel better emotionally and manage pain in daily life.

  NIH research University of Virginia · Charlottesville, United States · NIH-11465428

• Clinical Decision Support to Improve Low Back Pain Care

  A widely used digital tool helps doctors choose better, evidence-based care for people with low back pain in real clinics.

  NIH research Palmer College of Chiropractic · Davenport, United States · NIH-11448328

• Chronic Low Back Pain in Older Adults and Hip Impairments

  A study to help older adults with chronic low back pain, by looking at how hip problems affect their pain and function and testing tailored non-drug treatments.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11447991

• Mechanical signs from the spine’s discs that predict when back pain becomes long-lasting

  A Duke study aims to use new imaging and personal factors to see if the mechanical health of spinal discs can predict when acute low back pain becomes chronic.

  NIH research Duke University · Durham, United States · NIH-11446556

• Genetic predictors of recovery and surgical outcomes for Veterans with chronic low back pain and lumbosacral spine disorders

  This project uses VA health records and genetic information to find DNA markers linked to how Veterans fare with chronic low back pain and related spine conditions.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11446450

• Understanding how spinal cord injuries lead to chronic back and spine pain

  Researchers are studying how injuries to the thoracolumbar spine trigger lasting pain, with the goal of finding better treatments for people who have had traumatic spinal cord injuries.

  NIH research Virginia College of Osteopathic Medicine · Blacksburg, United States · NIH-11444618

• Whole-person approach to chronic low back pain with advanced phenotyping

  A large NIH project from the University of Pittsburgh aims to map and understand chronic low back pain through deep, real-world data on biology, behavior, and function to help tailor future treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419847

• Personalized multicomponent therapy for chronic low back pain using smart patient-based algorithms

  A U-Michigan-led effort tests a personalized approach to chronic low back pain by tailoring several treatments to individual patients using smart, data-driven decision rules.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11418354

• Understanding why neck, shoulder, arm, and back pain is common in full-busted women

  A study is exploring how factors like bra size and body mechanics relate to chronic pain in the neck, shoulders, arms, and back in women with larger breasts.

  NIH research University of Houston · Houston, United States · NIH-11418166

• Epigenetic drivers of chronic low back pain

  A patient-friendly look at how DNA methylation might influence disc-related back pain and potential new ways to treat it beyond opioids.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11418084

• What causes back pain flares and how to prevent them

  A back-pain study in Australia will use recent tech to see what triggers flare-ups in people with acute to chronic low back pain.

  NIH research University of Queensland · Brisbane, Australia · NIH-11417863

• Deep Brain Stimulation for Chronic Low Back Pain

  A new brain-targeted therapy is tested to help people with long-standing, hard-to-treat low back pain that hasn’t improved with other treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11417113

• Improving back-pain care in rural areas with tele-physical therapy

  This project tests a tele-rehabilitation program to help adults with chronic low back pain in rural communities access physical therapy and reduce opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11412950

• Biomarkers that reveal why acute low back pain becomes chronic

  A study on blood signals and immune factors in people with new acute low back pain to find clues that predict who will develop chronic pain.

  NIH research Duke University · Durham, United States · NIH-11412948

• A Better Way to Help People with Low Back Pain Using Radiofrequency Nerve Treatment

  A large NIH-supported study tests whether a targeted nerve-dulling procedure (radiofrequency ablation) can reliably help people with chronic low back pain who meet specific diagnostic criteria.

  NIH research University of Washington · Seattle, United States · NIH-11401715

• Mechanistic insights into chronic low back pain using patient tissues

  Researchers are studying nerve and tissue changes in people with chronic low back pain who are having spine surgery to find new clues that could lead to better treatments.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11399406

• Spine-hip exoskeletons with smart control to ease lower back pain

  A team is testing a spine-hip soft exoskeleton with learning-based control to reduce strain and injury risk for workers who lift heavy loads.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11394296

• Actigraphy-based Monitoring to Improve Chronic Low Back Pain Care

  A patient-friendly plan to use wearable activity data to better track and manage chronic lower back pain and its impact on daily life.

  NIH research Arbor Medical Innovations, LLC · Ypsilanti, United States · NIH-11389490

• Embedded ED Physical Therapy for Back Pain in the Emergency Department

  A dedicated physical therapist works with ED teams to help adults with back pain feel better sooner and reduce opioid use.

  NIH research Northwestern University · Chicago, United States · NIH-11384625

• Interprofessional Outpatient Therapy for Native Americans with Low Back Pain

  A collaborative outpatient program using physical and occupational therapy to help Cherokee Nation members manage low back pain without relying on drugs or surgery.

  NIH research Cherokee Nation · Tahlequah, United States · NIH-11369411

• Psilocybin for Chronic Back Pain: Brain Signals and Real-World Therapy Outcomes

  A patient-facing study will test whether a carefully controlled psilocybin treatment can improve body awareness and enhance physical therapy outcomes for people with chronic low back pain.

  NIH research Yale University · New Haven, United States · NIH-11359203

• Integrative Health Coaching in the ED for Back Pain after discharge

  A short, friendly program that uses personalized health coaching to help adults with acute flare-ups of chronic low back pain after leaving the emergency department, aiming to reduce opioid use and improve self-management.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11358903

• Increase use of non-drug therapies for chronic low back pain

  A study to help people with chronic low back pain use proven non-pharmacological therapies more often, by empowering patients to advocate for these treatments in their networks.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11358692

• Cannabis Coaching for Chronic Low Back Pain: A Multi-Site Feasibility Study

  A multi-site study tests a cannabis-coaching program designed to help people with chronic low back pain use legal cannabis products safely and effectively.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11358127

• Mindfulness-based brain science to reduce pain and opioid use in chronic back pain

  A study at UC San Diego tests how Mindfulness-Oriented Recovery Enhancement may help people with chronic low back pain use fewer opioids by changing brain activity.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11348866

• Understanding what causes disc-related back pain and how to treat it

  This grant explores how nerve growth, inflammation, and mechanical stress in the spinal disc contribute to chronic discogenic low back pain and whether targeting these factors can relieve pain.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11346026

• An adaptive plan to help pain after CBT for insomnia in people with chronic back pain

  A patient-facing program will test a supplemental, hopeful approach added to standard CBT for insomnia to see if it can reduce pain for people who have chronic low back pain and insomnia.

  NIH research University of Virginia · Charlottesville, United States · NIH-11332862

• Auricular stimulation for chronic low back pain: brain changes measured with noninvasive imaging

  A noninvasive study tests whether ear-based stimulation changes brain activity and connectivity in healthy volunteers and people with chronic low back pain.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11325702

• Virtual reality program to reduce chronic low back pain

  This project will see if a virtual-reality, brain-targeting treatment can reduce long-term low back pain in adults.

  NIH research Cognifisense, INC. · Sunnyvale, United States · NIH-11322088

• Acupuncture for Medicare Beneficiaries with Chronic Low Back Pain

  This project looks at how coverage of acupuncture for chronic low back pain in Medicare beneficiaries affects outcomes, access, and costs.

  NIH research Southern California Univ of Health Scis · Whittier, United States · NIH-11311347

• How fat builds up in back muscles with chronic low back pain

  Researchers will use advanced MRI plus movement and muscle tests to link patterns of fat in back muscles to symptoms in people with chronic low back pain.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11306684

• Spinal movement problems and early low back pain recovery

  This project looks at whether certain spine movement problems in adults with new low back pain affect how quickly and how well they recover, and whether treating those problems helps.

  NIH research Washington University · Saint Louis, United States · NIH-11296839

• Brain changes in chronic low back pain across ages and sexes

  This project looks for brain-based markers of long-term low back pain and how aging and biological sex change those brain patterns for people with chronic low back pain.

  NIH research University of Rochester · Rochester, United States · NIH-11295443

• Understanding how the immune system affects chronic back pain

  A research study is exploring how immune system signals and antibodies contribute to low back pain and how this could lead to better treatments for people with persistent back pain.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11268384

• Engineered tiny vesicles to reprogram and heal degenerated spinal discs

  A non-surgical approach using engineered extracellular vesicles aims to reprogram damaged disc cells to restore disc health and reduce chronic disc-related low back pain for people with discogenic pain.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11262849

• How race and income affect long‑term low back pain

  This project looks at why adults of different races and socioeconomic backgrounds, especially Black and White adults, experience different levels of long‑lasting low back pain.

  NIH research Washington University · Saint Louis, United States · NIH-11251322

• Two neurosteroid medicines being tested for chronic low back pain in U.S. veterans

  This project will compare two experimental neurosteroid medicines against a placebo to see if they safely ease chronic low back pain in U.S. military veterans.

  NIH research Durham VA Medical Center · Durham, United States · NIH-11249118

• Understanding the causes of low back pain related to disc degeneration

  This study is looking into how issues with your back discs can cause ongoing pain, focusing on how stress and inflammation affect nerves in those discs, with the hope of finding new ways to help relieve that pain.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-11247718

• UCSF REACH: smarter understanding of chronic low back pain using big data and models

  A big NIH grant will help UCSF build and test a data-driven model to understand chronic low back pain and guide better care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11211838

Related topics

Quick answers

How many Back Pain clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (10 trials), Turkey (Türkiye) (3 trials), Belgium (2 trials), France (1 trial), Switzerland (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 4: 2, Phase 3: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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