Brain imaging to predict response to spinal cord stimulation for chronic low back pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate brain imaging biomarkers that may predict how patients with chronic low back pain respond to spinal cord stimulation (SCS). A total of 42 participants will undergo brain mapping studies as part of their normal clinical care over a two-year period. Participants will have two visits: one for baseline imaging and assessments, and a follow-up visit two weeks after SCS treatment for final assessments. The study focuses on the connectivity of specific brain regions to understand their relationship with treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female ≥ 21 years of age at time of consent
* Subject has been recommended to undergo an SCS trial for chronic back with or without leg pain by their pain management physician
* Chronic low back pain as defined by persistent low back pain despite prior treatments that continues for 12 weeks or longer
* Subject signs a valid, Institutional Review Board (IRB)-approved informed consent form (ICF) provided

Exclusion Criteria:

* Subject is a woman who is not using adequate contraception, is pregnant or breastfeeding or intends to become pregnant during the course of the study
* Subject has previously undergone a spinal cord stimulation trial or is already implanted with an active implantable device(s) to treat their pain (Implantable Pulse Generators (IPGs), implantable drug pump, etc.) or pacemaker or implantable cardiac defibrillator
* Subject is currently abusing alcohol or illicit drugs
* Contraindications to MRIs or the need for recurrent body MRIs
* Presence of cardiac pacemakers/defibrillators, implanted medication pumps, intra-cardiac lines, any intracranial implants (e.g., aneurysm clip, shunt, cochlear implant, electrodes) or other implanted stimulators

Where it's running

• University of California Los Angeles
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Meskereen Tolossa
• Email: MTolossa@mednet.ucla.edu
• Phone: 310-206-9187

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.