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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Mindfulness-based treatment for chronic low back pain

Official title: Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

Run by Boston Medical Center · NCT06106191 · Data updated 2026-11-12

This study is testing how well an 8-week mindfulness program helps people with chronic low back pain and what factors might affect their results.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment350 (estimated)
SponsorBoston Medical Center
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedJuly 25, 2024
Main results expectedSeptember 2028
Study endsDecember 2029
Registry record updatedJune 30, 2026
Trial IDNCT06106191 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals experiencing chronic low back pain for at least three months who are willing to participate in an online intervention.

Probably not a fit

Patients with recent worsening pain, pregnancy, metastatic cancer, or those not planning to remain patients at a participating clinic may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify unique biological, psychological, and social markers that influence the response of individuals with chronic low back pain (cLBP) to Mindfulness-Based Stress Reduction (MBSR) using machine learning techniques. Over a 24-month period, researchers will collect comprehensive biopsychosocial data from participants to develop predictive models for treatment response. The study will involve a single-arm clinical trial with 300 participants undergoing an 8-week MBSR program conducted via Zoom, with assessments at multiple time points to evaluate pain and functional outcomes.

Why it matters

Potential benefit: If successful, this approach could lead to more personalized and effective treatments for patients suffering from chronic low back pain.

How similar studies have gone: Other studies have shown promise in using mindfulness-based approaches for pain management, but this specific predictive modeling approach is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Chronic low back pain, which is pain that persists for at least 3-months and has resulted in pain on at least half the days in the past 6 months
* Willing and able to provide online or telephone informed consent
* Speak English as the intervention manual is currently written in English

Exclusion Criteria:

* Red flags- recent (past month) worsening of pain, unexplained fever, unexplained weight loss
* Pregnancy
* Metastatic cancer
* Not a patient at a participating clinic or persons not planning to continue as a patient at a participating clinic for 6 or more months

Where it's running

  • Boston Medical Center
    Boston, Massachusetts, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.