See if serum BDNF levels relate to outcomes in chronic low back pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study explores whether serum Brain-Derived Neurotrophic Factor (BDNF) levels are linked to clinical outcomes in adults with chronic low back pain due to disc degeneration or spinal stenosis. Blood samples will be collected for ELISA analysis alongside standard assessments, and participants may receive an erector spinae plane block as part of the protocol. The study relies on MRI-confirmed disc pathology and excludes patients with conditions or medications known to affect BDNF. By correlating BDNF with pain, function, and other outcomes, the trial aims to identify potential markers for prognosis or stratification. The investigation is conducted at Keimyung University Dongsan Medical Center in Daegu, Korea.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic low back pain patients with or without leg pain due to disc degeneration or spinal stenosis
* Patients who have MRI

Exclusion Criteria:

* Secondary low back pain (spine fracture, infection, tumor)
* recent history of spine surgery
* systemic inflammatory disease (rheumatoid arthritis, SLE, ankylosing spondylitis)
* peripheral neuropathy or central nervous system injury
* fibromyalgia
* drugs which can affect the serum BDNF level (anti depressant, anti parkinsonian drug, acetylcholinesterase inhibitor, anti psychotics)

Where it's running

• Ji Hee
  Daegu, Daegu, South Korea Recruiting

Study contacts

• Study coordinator: JIHEE Hong
• Email: swon13@daum.net
• Phone: 01046794343

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound-Guided Thoracolumbar Fascia Injection for Chronic Low Back Pain in Type 2 Diabetes

  This trial tests whether an ultrasound-guided injection into the thoracolumbar fascia, added to standard care, helps reduce chronic low back pain in adults with type 2 diabetes.

  Recruiting Kanuni Sultan Suleyman Training and Research Hospital · Küçükçekmece, Istanbul · NCT07927530

• Subcutaneous Fat, Back Muscles, and Spine Shape in Back Pain Patients

  This study tests whether body fat under the skin and features of back muscles and spine joints are linked to lumbar facet joint degeneration in adults with chronic low back pain.

  Recruiting Marmara University · Istanbul, Istanbul · NCT07860697

• Correlating periostin levels with spinal degeneration in back pain

  This study tests whether periostin levels in the intervertebral disc relate to the severity of disc degeneration in people with chronic low back pain and spinal stenosis.

  Recruiting Keimyung University Dongsan Medical Center · Daegu, Daegu · NCT07776366

• Palmitoylethanolamide for Central Sensitisation and Neuroinflammation in Chronic Low Back Pain

  A treatment with palmitoylethanolamide is being tried to see if it helps people with chronic low back pain who have nerve-related pain and disc problems.

  Recruiting Beni-Suef University · Banī Suwayf · NCT07772141

• Multichannel neuromuscular stimulation plus core exercise for chronic low back pain

  This study tests two multichannel neuromuscular electrical stimulation programs added to a core exercise plan to see if they help adults with chronic non-specific low back pain.

  Recruiting Uskudar University · Şırnak · NCT07760142

• Algorithm-informed care to find the best pain treatment for chronic low back pain

  This study tests whether an algorithm that uses a patient’s symptoms, history, and lifestyle can help pick the best treatment from physical therapy, duloxetine, acupressure, or PRISM-CBT for people with chronic low back pain.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07731750

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.