Condition

Brain Metastases clinical trials and research

• 74Clinical trials
• 38NIH research projects
• 21Countries

Newest Brain Metastases clinical trials

All recruiting trials (74)

• EarlyFDG PET after Radiotherapy to See Brain Metastases and Radionecrosis

  This study tests whether a short FDG-PET scan after radiotherapy can help tell apart radionecrosis from recurring brain metastases in adults.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07632092

• IL-8 receptor–modified CAR T cells for brain metastases in adults

  This phase 1 study tests whether patient-derived, IL-8 receptor–modified CD70 CAR T cells can be safely given to adults with brain metastases.

  Recruiting Phase 1 University of Florida · Gainesville, Florida · NCT07569263

• Targeted FSRT plus bevacizumab versus hippocampus-sparing whole-brain radiation for people with lung adenocarcinoma that has spread to the brain

  This will test whether focused 5-day fractionated stereotactic radiotherapy (FSRT) combined with bevacizumab works better than hippocampus-avoidant whole-brain radiotherapy with a simultaneous boost at controlling brain metastases and protecting memory in adults with lung adenocarcinoma and extensive brain metastases.

  Recruiting at 3 sites Phase 3 Sun Yat-sen University · Chongqing, Chongqing Municipality and 2 other locations · NCT07481786

• Molecular comparison of primary gastroesophageal cancers and their brain metastases

  This project will test whether key biomarkers (HER2, MSI, PD-L1, CLDN18.2) match between primary gastroesophageal tumors and their matched brain metastases using archived tissue.

  Recruiting Blokhin's Russian Cancer Research Center · Moscow · NCT07464470

• Imaging inflammation in primary and metastatic brain tumors with [C-11]-CS1P1 PET

  This trial will test a new PET tracer, [C-11]-CS1P1, in adults with primary or secondary brain tumors to see if tracer patterns of inflammation relate to MRI, treatments, and clinical outcomes.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07462507

• Cognitive stepped care program for adults with brain metastases

  This project will test whether routine screening plus a stepped program of education and tailored cognitive support can help adults with brain metastases manage thinking and memory problems.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07355348

• Memory-avoidance whole brain radiotherapy: trying to protect memory while treating brain metastases

  This study tests whether memory-avoidance whole brain radiotherapy with memantine is better at preserving thinking and memory than hippocampal-avoidance whole brain radiotherapy with memantine for adults with brain metastases.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07248228

• Staged stereotactic radiosurgery versus fractionated stereotactic radiotherapy for larger brain metastases

  This trial tests whether staged stereotactic radiosurgery or fractionated stereotactic radiotherapy better controls brain metastases 2–5 cm in adults while reducing side effects.

  Recruiting Phase 2 Medical University of South Carolina · Charleston, South Carolina · NCT07227610

• Intraoperative MRI to improve brain metastasis surgery

  This study will test whether using intraoperative MRI during surgery helps surgeons remove brain metastases more completely and with fewer repeat operations.

  Recruiting Technical University of Munich · Munich · NCT07197632

• Dual Energy CT to Delineate Tumors and Organs at Risk in Radiotherapy

  This study tests whether dual-energy CT can delineate tumors and nearby critical tissues as well as MRI for patients needing radiotherapy.

  Recruiting at 2 sites Aalborg University Hospital · Aalborg and 2 other locations · NCT07185958

• 7T MRI to detect tiny brain metastases in adults with small-cell lung cancer who decline preventive cranial irradiation.

  Try a higher-strength 7T brain MRI to see if it finds tiny brain metastases earlier in adults with small-cell lung cancer who decline preventive cranial radiation.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07175077

• Personalized PULSAR radiotherapy for advanced small cell lung cancer and brain metastases

  This trial will try personalized PULSAR radiotherapy schedules to see if they are safe and helpful for adults with extensive-stage small cell lung cancer who need thoracic radiation and for adults with 1–5 brain metastases.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07139990

• Trastuzumab rezetecan with or without radiotherapy for HER2‑positive advanced breast cancer that has spread to the brain.

  This trial will test whether adding radiotherapy to trastuzumab rezetecan helps adults with HER2‑positive advanced breast cancer and untreated brain metastases control their brain tumors better than the drug alone.

  Recruiting Phase 2 Henan Cancer Hospital · Zhengzhou, Henan · NCT07100600

• Surgery or LITT followed by a second focused radiosurgery versus close monitoring for recurrent brain metastases

  This trial tests whether giving a second course of stereotactic radiosurgery after surgery or LITT helps people with recurrent brain metastases keep the tumor from coming back compared with close monitoring.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07053033

• No perioperative dexamethasone for brain metastasis surgery

  This trial will try skipping perioperative dexamethasone in adults having surgery for newly diagnosed brain metastases to see if it is safe and reduces lymphopenia.

  Recruiting University of Louisville · Louisville, Kentucky · NCT07044557

• Combining fractionated stereotactic radiosurgery with surgery for brain metastases

  This study is testing whether giving radiation therapy before surgery can help people with brain tumors from cancers like lung, breast, and melanoma have better outcomes and fewer complications.

  Recruiting Regina Elena Cancer Institute · Rome · NCT06992973

• Neoadjuvant Stereotactic Radiotherapy for Brain Metastases

  This study is testing a new type of targeted radiation therapy for people with brain metastases to see if it can improve their survival and quality of life.

  Recruiting at 4 sites University Hospital Ostrava · Ostrava, Moravian-Silesian Region and 3 other locations · NCT06933199

• Comparing radiation margins in treating brain metastases with radiosurgery

  This study is testing whether using different amounts of space around brain tumors during radiation treatment can help control the tumors better and reduce side effects for patients with brain metastases.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06857006

• Datopotamab-deruxtecan with carboplatin and pembrolizumab for treatment‑naive NSCLC that has spread to the brain

  This trial will try giving datopotamab-deruxtecan together with carboplatin and pembrolizumab to adults with metastatic non‑small cell lung cancer that has spread to the brain and has no targetable mutations.

  Recruiting at 13 sites Phase 2 Latin American Cooperative Oncology Group · Fortaleza, Ceará and 12 other locations · NCT06822543

• Treatment for brain metastases in triple-negative breast cancer using Ivonescimab and TROP2 ADC

  This study is testing a new combination treatment of ivonescimab and TROP2 antibody-drug conjugates for patients with triple-negative breast cancer that has spread to the brain to see if it helps them feel better and live longer.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT06793332

• Relatlimab, nivolumab, and ipilimumab for melanoma that has spread to the brain

  This trial will test whether the combination of relatlimab, nivolumab, and ipilimumab can help adults with melanoma brain metastases, including those with and without symptoms.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT06712927

• Combining Cadonilimab with Stereotactic Radiotherapy for Brain Metastases Treatment

  This study is testing if combining a new drug called Cadonilimab with targeted radiation therapy can help people with brain metastases from lung cancer feel better and have fewer side effects than current treatments.

  Recruiting Phase 2 Xiangya Hospital of Central South University · Changsha, Hunan · NCT06702826

• Exploring combined local and systemic treatments for brain metastases

  This study is testing whether a new approach that combines targeted radiation with standard treatments can help people with brain metastases who have seen some improvement or stability after their initial therapy.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06649058

• Combining TIL Therapy and Pembrolizumab for Advanced Brain Cancer

  This study is testing a new treatment that combines a type of immune therapy using patients' own tumor cells with Pembrolizumab to see if it helps people with advanced brain cancer feel better and live longer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06640582

• Using ex vivo pharmacoscopy to guide treatment for brain metastases

  This project will test whether pharmacoscopy, a lab test that screens a patient's tumor cells against many drugs, can help pick effective treatments for adults having surgery for brain metastases.

  Recruiting at 2 sites Phase 2 University of Zurich · Basel and 2 other locations · NCT06620380

• Combining cranial radiotherapy with chemoimmunotherapy for lung cancer patients with brain metastasis

  This study is testing if combining brain radiation with a new type of immunotherapy and chemotherapy can help people with advanced lung cancer and brain metastases live longer and better.

  Recruiting Phase 2 Fudan University · Shanghai · NCT06501391

• Combining SRT and Anlotinib for treating brain metastases from lung cancer

  This study is testing if combining a targeted cancer drug called Anlotinib with a type of focused radiation therapy can help patients with non-small cell lung cancer who have limited brain metastases and haven't responded to other treatments.

  Recruiting The First People's Hospital of Lianyungang · Lianyungang, Jiangsu · NCT06476093

• Corticodependent or corticoresistant brain radionecrosis after radiotherapy for brain metastases

  This trial tests whether the drug bevacizumab helps people with steroid‑dependent or steroid‑resistant brain radionecrosis following radiotherapy for brain metastases.

  Recruiting at 9 sites Phase 3 Institut Cancerologie de l'Ouest · Brest and 9 other locations · NCT06471465

• Comparing two radiation therapies for brain metastases in small-cell lung cancer

  This study is testing whether two types of targeted radiation therapy can be better options than standard whole brain radiation for people with small-cell lung cancer that has spread to the brain.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06457906

• Repotrectinib for treating ROS1-positive lung cancer with brain metastasis

  This study is testing a new drug called repotrectinib to see if it can help people with ROS1-positive lung cancer that has spread to the brain.

  Recruiting at 17 sites Phase 2 MedSIR · Graz and 16 other locations · NCT06315010

• Hippocampal-sparing whole brain radiotherapy combined with stereotactic radiotherapy for extensive-stage small cell lung cancer with brain metastases

  This study is testing a new type of brain radiation treatment for people with extensive-stage small cell lung cancer that has spread to the brain, to see if it can help control their cancer while protecting their memory.

  Recruiting Phase 1/2 Fudan University · Shanghai · NCT06243003

• Combining nitroglycerin with radiation therapy for lung cancer patients with brain metastases

  This study is testing if adding nitroglycerin to radiation therapy can help lung cancer patients with brain metastases live longer and feel better.

  Recruiting Instituto Nacional de Cancerologia de Mexico · Mexico City, Mexico City · NCT06238882

• Treatment for brain metastases from melanoma using defactinib and avutometinib

  This study is testing if a combination of two drugs, defactinib and avutometinib, can help people with brain tumors from melanoma feel better after their previous treatments didn't work.

  Recruiting at 2 sites Phase 1/2 University of Utah · Iowa City, Iowa and 1 other locations · NCT06194929

• Using MRI to Differentiate Between Brain Tumors and Radiation Effects

  This study is testing a new MRI technique to see if it can help tell the difference between brain tumors and radiation damage in people who have had radiation therapy.

  Recruiting at 2 sites Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT06101069

• Using 18F-FES PET/CT imaging for breast cancer patients with brain metastases

  This study is testing a special type of imaging to see if it can help doctors better understand brain tumors in breast cancer patients and improve their treatment plans.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT06072807

• Using 18F-Fluciclovine PET/CT to Identify Brain Metastasis

  This study is testing if a special type of PET scan can help doctors find brain metastases more accurately in patients who have unclear MRI results.

  Recruiting Early Phase 1 University of Arizona · Tucson, Arizona · NCT06055790

• Evaluating brain metastasis treatment using PET imaging

  This study is testing if a special type of brain scan can help doctors see how well treatment is working for patients with brain tumors caused by cancer.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT06048094

• Assessing tumor hypoxia using MRI to improve radiation therapy

  This study is testing if special MRI scans can help doctors understand and improve radiation treatment for patients with head and neck cancer or brain metastases by looking at how much oxygen their tumors are getting.

  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05996432

• Comparing brain radiotherapy timing in lung cancer patients with ALK rearrangements

  This study is testing whether a targeted lung cancer treatment called alectinib works better alone or with brain radiation for patients who have lung cancer with specific genetic changes and brain metastases.

  Recruiting at 3 sites Phase 1/2 Hoosier Cancer Research Network · Stanford, California and 2 other locations · NCT05987644

• Using MRI to improve diagnosis of brain damage from lung cancer treatment

  This study tests a new MRI method to see if it can better diagnose brain damage in lung cancer patients who have had radiation treatment and are facing complications.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05977803

• Evaluating TY-9591 for treating advanced lung cancer with brain metastases

  This study is testing a new drug called TY-9591 to see if it can help people with advanced lung cancer that has spread to the brain, compared to a standard treatment.

  Recruiting Phase 2 TYK Medicines, Inc · Beijing, Beijing Municipality · NCT05948813

• Evaluating BDTX-4933 for patients with specific cancer mutations

  This study is testing a new drug called BDTX-4933 to see if it can help adults with advanced cancers that have certain gene mutations feel better and improve their treatment options.

  Recruiting at 34 sites Phase 1/2 Servier · Gilbert, Arizona and 48 other locations · NCT05786924

• Comparing early and delayed brain radiotherapy with Almonertinib for lung cancer patients with brain metastases

  This study is testing whether giving brain radiotherapy right away or waiting a bit longer, along with a new lung cancer medication, helps people with brain metastases live longer and feel better.

  Recruiting Phase 3 Sun Yat-sen University · Guangdong, Guangzhou · NCT05768490

• Combining niraparib and dostarlimab for advanced cancers with brain metastases

  This study is testing if combining two drugs, niraparib and dostarlimab, can help people with advanced cancers that have spread to the brain feel better and respond to treatment.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05700721

• Monitoring the brain with MRI to detect cancer spread early

  This study is testing if regular brain MRI scans after radiation therapy can help catch cancer spread in patients with advanced lung cancer before they start showing symptoms.

  Recruiting Phase 2 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05692635

• Combination treatment for HER2-positive metastatic solid tumors with brain metastases

  This study is testing if a combination of two drugs can help people with HER2-positive metastatic solid tumors that have spread to the brain feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05673928

• New MRI technique to assess brain tumors after treatment

  This study is testing a new MRI method to see if it can tell the difference between real tumor growth and changes caused by treatment in people with brain tumors.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT05559853

• Using a special imaging agent to evaluate brain metastases after surgery

  This study is testing a special imaging agent to see if it can help doctors find leftover brain tumors after surgery and improve care for patients with brain cancer.

  Recruiting Phase 2 Baptist Health South Florida · Miami, Florida · NCT05554302

• Combining UTD1 and Capecitabine for HER2-negative Breast Cancer with Brain Metastases

  This study is testing if a new treatment combining UTD1 and Capecitabine can help people with HER2-negative breast cancer that has spread to the brain.

  Recruiting Phase 1/2 Hunan Cancer Hospital · Changsha · NCT05535413

• Using advanced imaging techniques to improve brain cancer diagnosis

  This study is testing a new imaging technique to see if adding special scans can help doctors better diagnose brain cancer in patients getting PET/MRI exams.

  Recruiting Centre Paul Strauss · Strasbourg · NCT05464992

• Using a new imaging agent to detect lung cancer spread

  This study is testing a new imaging method to see if it can better detect the spread of lung cancer, especially to the brain, in patients with Non-Small Cell Lung Cancer.

  Recruiting Phase 1 University of California, Davis · Sacramento, California · NCT05452005

• Stereotactic radiosurgery for lung cancer that has spread to the brain

  This study is testing if a targeted radiation treatment can help people with small cell lung cancer that has spread to their brain feel better and improve their outcomes.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05419076

• Evaluating Cyberknife Radiosurgery for Patients with Multiple Brain Metastases

  This study is testing whether a new type of targeted radiation treatment called Cyberknife can help people with multiple brain tumors live better and longer compared to standard whole-brain radiation therapy.

  Recruiting University Hospital Heidelberg · Heidelberg · NCT05378633

• New treatment method for brain metastases using fractionated stereotactic radiotherapy

  This study is testing a new way to treat brain metastases using a different form of radiation therapy to see if it can reduce side effects while still helping patients live longer and feel better.

  Recruiting Haaglanden Medical Centre · Leidschendam, South Holland · NCT05346367

• Evaluating the CONVIVO System for Brain Tumor Surgery

  This study is testing a new imaging tool during brain tumor surgery to see if it can better tell the difference between healthy and unhealthy brain tissue for patients with brain tumors.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT05139277

• Treatment for recurrent brain metastases after radiation therapy

  This study is testing whether Laser Interstitial Thermal Therapy or other radiation treatments work better for patients with brain tumors that have come back after previous radiation therapy.

  Recruiting at 8 sites Monteris Medical · Los Angeles, California and 8 other locations · NCT05124912

• Combining pembrolizumab and lenvatinib for treating brain metastases in cancer patients

  This study is testing if combining two cancer drugs, pembrolizumab and lenvatinib, can help patients with solid tumors and brain metastases, especially those with triple negative breast cancer or non-small cell lung cancer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05064280

• Combining nivolumab, ipilimumab, and cabozantinib for untreated kidney cancer that has spread to the brain

  This trial tests whether adding the oral drug cabozantinib to two immunotherapy medicines (nivolumab and ipilimumab) helps people with untreated renal cell carcinoma brain metastases live longer or have their brain tumors shrink.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05048212

• Using a new radiation technique to treat brain metastases

  This study is testing a new way of giving radiation to treat brain tumors in adults to see if it helps them tolerate the treatment better and protects their thinking skills.

  Recruiting at 2 sites Phase 2 Medical College of Wisconsin · Milwaukee, Wisconsin and 1 other locations · NCT05045950

• Evaluating Osimertinib with Early Stereotactic Radiosurgery for EGFR Mutated NSCLC with Brain Metastases

  This study is testing if combining a lung cancer drug called Osimertinib with early targeted radiation therapy can help people with EGFR-mutated non-small cell lung cancer and brain metastases live longer and maintain better brain function.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT05033691

• Normal tissue sparing radiation therapy for brain metastases

  This study is testing a new type of radiation therapy that aims to protect healthy brain tissue while treating brain metastases, to see if it improves quality of life for patients receiving it along with a standard medication.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT05013892

• Combining Stereotactic Radiation with Abemaciclib for Breast Cancer Brain Metastases

  This study is testing if combining a medication called abemaciclib with targeted radiation can help people with hormone receptor-positive breast cancer that has spread to the brain live longer without their cancer getting worse.

  Recruiting Phase 1/2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida and 1 other locations · NCT04923542

• Using nanoparticles to enhance radiation treatment for brain metastases

  This study is testing if adding special nanoparticles to radiation therapy can help people with brain metastases get better results than radiation alone.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04899908

• Using MRI to Differentiate Between Brain Metastasis Progression and Radionecrosis After Gamma Knife Treatment

  This study is testing a new MRI method to see if it can help tell the difference between brain cancer growth and treatment side effects in patients who have had gamma knife therapy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04833335

• Using 18F-Fluciclovine to Monitor Brain Metastases After Radiation Therapy

  This study is testing a new imaging agent called 18F-fluciclovine to see if it can help track how well radiation therapy is working for people with large brain metastases.

  Recruiting Phase 1 Baptist Health South Florida · Miami, Florida · NCT04689048

• Using MRI to guide radiation therapy for various cancers

  This study is testing if using MRI scans to adjust radiation therapy can help people with different types of cancer, like pancreatic and lung cancer, feel better and control their tumors more effectively.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04115254

• Understanding brain changes after radiation treatment for brain metastases

  This study is testing how radiation treatment for brain metastases affects thinking and memory over a year to help improve future care for patients.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT04073966

• Testing a new radiation therapy for brain metastases

  This study is testing a new type of radiation therapy for people with brain metastases to see how safe it is and what the best dose might be.

  Recruiting Albert Einstein College of Medicine · The Bronx, New York · NCT03726359

• Comparing two radiation treatments for brain metastases

  This study is testing whether a new type of targeted radiation treatment works better than a standard whole brain radiation treatment for people with multiple brain tumors.

  Recruiting at 47 sites Phase 3 Canadian Cancer Trials Group · Tucson, Arizona and 85 other locations · NCT03550391

• Pembrolizumab and Stereotactic Radiosurgery for Breast Cancer Brain Metastases

  This study is testing if combining an immunotherapy drug called pembrolizumab with a targeted radiation treatment can help people with metastatic breast cancer who have multiple brain tumors.

  Recruiting at 3 sites Phase 1/2 Weill Medical College of Cornell University · New York, New York and 2 other locations · NCT03449238

• Using advanced MRI to study brain metastases in cancer patients

  This study is testing a special MRI technique to see how brain tumors in cancer patients use energy and how that might affect their treatment outcomes.

  Recruiting Phase 1 Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT03324360

• Frameless stereotactic radiosurgery for intact brain metastases

  This trial will test whether omitting planning target volume (PTV) margins during frameless stereotactic radiosurgery changes progression-free survival in adults with 1–5 brain metastases.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT02747303

• Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Cognitive Function

  This study is testing whether a special type of brain radiation that avoids the hippocampus can help people with brain tumors keep their thinking skills better than regular radiation.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT02504788

• Increasing radiation doses for treating brain metastases

  This study is testing higher doses of radiation during a specific type of surgery to see if it can safely help people with untreated brain metastases feel better.

  Recruiting Phase 1 University of Utah · Salt Lake City, Utah · NCT02390518

NIH-funded research (38)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding and interrupting brain metastasis in cancer patients

  A national research effort at Stanford aims to understand why cancer spreads to the brain and to develop ways to interrupt it, with the goal of improving survival and quality of life for people with cancer.

  NIH research Stanford University · Stanford, United States · NIH-11517622

• Rational approaches to improve treatment for breast cancer that has spread to the brain

  Aimed at boosting how well a HER2-targeted antibody-drug conjugate works for people whose breast cancer has spread to the brain.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11414846

• Understanding how brain metastasis in triple-negative breast cancer is shaped by tumor-immune interactions

  A patient-focused program aims to learn why TNBC spreads to the brain and how the immune system interacts with those cancer cells, with a focus on women of African ancestry.

  NIH research University of California at Davis · Davis, United States · NIH-11411191

• AI-driven automatic treatment planning for brain metastases radiotherapy

  A new AI-based system helps plan precise stereotactic radiosurgery for people with multiple brain metastases.

  NIH research University of Chicago · Chicago, United States · NIH-11408679

• Endocrine therapy and radiation work together to reduce brain metastases

  Aims to understand how hormone therapy and radiation together help the body fight breast cancer that has spread to the brain, especially in younger women.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11398946

• Personalized brain metastases risk map to guide radiotherapy

  A new approach uses personal MRI data to predict where brain metastases might develop so radiation can target high-risk areas and spare healthy brain tissue.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11397221

• Clinical CEST MRI Fingerprinting to Track Brain Metastasis Treatment Response

  A patient-facing overview of a new MRI method that uses advanced imaging and AI to measure how brain metastases respond to treatment.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11384800

• Integrated MRI and blood markers to predict radiation failures in brain metastases from NSCLC

  Aims to build a person-friendly model using MRI scans and blood biomarkers to predict how brain metastases from non-small cell lung cancer will respond to radiation therapy.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11374199

• Advanced non-contrast MRI to track blood flow in brain metastases

  This project develops improved non-contrast MRI methods that track blood flow in brain metastases to help doctors see how tumors respond to treatment.

  NIH research University of Washington · Seattle, United States · NIH-11374112

• Stopping RET-driven breast cancer spread to the brain

  This project looks at whether blocking the RET protein can slow or stop breast cancer that has spread to the brain.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11333968

• Enhancing brain metastases care with clear AI insights

  A physician-scientist at MGH will use interpretable deep learning to understand why brain metastases resist treatment and how to tailor therapy for patients.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11332763

• Timing chemotherapy to help breast cancer that has spread to the brain

  This project will see if giving common breast cancer chemotherapy at certain times of day helps the medicines get into brain tumors better for people with breast cancer that has spread to the brain.

  NIH research West Virginia University · Morgantown, United States · NIH-11296911

• Following neural stem cells that target breast cancer spread in the brain

  Researchers will build high-resolution, non-invasive imaging to watch therapeutic neural stem cells move to breast cancer brain metastases to support better-targeted treatments for patients.

  NIH research Northwestern University · Chicago, United States · NIH-11238077

• Hormone-blocking treatment plus radiation to reduce breast cancer spread to the brain

  This project looks at whether combining hormone-blocking drugs with radiation helps the immune system stop breast cancer from spreading to the brain in women, especially younger patients.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11180134

• Understanding how brain immune cells support brain tumors

  This study is looking at how special immune cells in the brain, called microglia, help support aggressive brain tumors, and it's for anyone interested in understanding how these cells interact with tumors to find new ways to slow down their growth.

  NIH research Stanford University · Stanford, United States · NIH-11178804

• AI-assisted radiosurgery planning for multiple brain metastases

  This project uses artificial intelligence to create faster, personalized radiosurgery plans for people with multiple brain metastases.

  NIH research University of Chicago · Chicago, United States · NIH-11175332

• Blocking brain immune cells that help cancer spread to the brain

  This project aims to stop brain immune cells called microglia from helping metastatic cancers grow in people with brain metastases.

  NIH research Stanford University · Stanford, United States · NIH-11174235

• Stopping the interactions between cancer, nerves, and immune cells that let tumors grow in the brain

  This program aims to find and block the signals between cancer cells, brain cells, and the immune system that let cancers spread to and grow in the brain, to help people with cancers at risk of brain metastases.

  NIH research Stanford University · Stanford, United States · NIH-11174229

• MRI technique to track treatment response in brain metastases

  Creates a faster MRI method that measures chemical changes in brain tumors to help people with brain metastases see whether their treatments are working.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11134518

• Better drug delivery for breast cancer that has spread to the brain

  New methods to deliver cancer-fighting drugs into the brain for people whose breast cancer has spread there.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11130937

• How timing chemotherapy can improve treatment for brain metastases in breast cancer

  This study is looking at how the time of day affects the ability of chemotherapy drugs to reach the brain in patients with breast cancer that has spread to the brain, with the goal of making treatments work better and cause fewer side effects.

  NIH research West Virginia University · Morgantown, United States · NIH-11062431

• Creating models of melanoma brain tumors to improve immune therapy

  This study is creating tiny models of brain tumors from melanoma patients to see how immune cells work in these tumors and to try out new treatments that could help improve care for people with melanoma that has spread to the brain.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11051251

• Tracking how neural stem cells move to brain tumors in breast cancer patients

  This study is looking at how special brain cells called neural stem cells move towards tumors in the brains of breast cancer patients, with the hope of using these cells to deliver better treatments directly to the tumors.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11022299

• Improving treatment for breast cancer that has spread to the brain

  Trying antibody-drug combinations and immune-targeting drugs to help people with HER2-positive or HER2-low breast cancer that has spread to the brain.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11015467

• Understanding and disrupting the connection between cancer and the brain's immune system to prevent brain metastases.

  This study is looking into how cancer spreads to the brain and aims to find better treatments for patients who are affected, so they can have improved survival and quality of life.

  NIH research Stanford University · Stanford, United States · NIH-10977543

• Investigating how to overcome resistance of breast cancer that has spread to the brain to a specific treatment

  This study is looking into why breast cancer that spreads to the brain often doesn't respond well to a certain treatment, and it's working to find new ways to help patients get better options that can effectively target these tough-to-treat brain tumors.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10947332

• Using artificial intelligence to improve treatment planning for multiple brain metastases.

  This study is looking at how we can use smart computer technology to create better and more personalized treatment plans for patients with multiple brain tumors, helping them get targeted radiation therapy that is easier on their thinking and memory.

  NIH research University of Chicago · Chicago, United States · NIH-10927272

• Understanding how brain immune cells support brain tumors

  This study is looking at how special immune cells in the brain, called microglia, help support aggressive brain tumors, and it's for anyone interested in understanding how these cells interact with tumors to find new ways to treat them.

  NIH research Stanford University · Stanford, United States · NIH-10925241

• Understanding and disrupting the processes that allow cancer to spread to the brain.

  This study is looking into how cancer spreads to the brain, which can happen to many cancer patients, and aims to find better ways to treat this issue by exploring how cancer interacts with the brain and immune system, so that patients can eventually benefit from new treatment options.

  NIH research Stanford University · Stanford, United States · NIH-10925234

• Improving MRI techniques to monitor brain metastases treatment response

  This study is testing a new way to use MRI scans without contrast dye to see how well brain tumors are responding to treatment, making it easier and safer for patients to track their progress over time.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10914899

• Understanding how hormone therapy and radiation work together to reduce brain metastases in breast cancer.

  This study is looking at why young women with breast cancer often face tougher challenges, like aggressive tumors and brain spread, and it’s exploring how certain hormone treatments combined with radiation might help boost the immune system to fight these issues better.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10902514

• New ways to deliver drugs for treating breast cancer that has spread to the brain

  This study is looking for better ways to deliver cancer treatments to women with breast cancer that has spread to the brain, especially for those with tougher types like triple negative and HER2-positive, to help improve their treatment outcomes.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-10881721

• New MRI method to assess treatment response in brain tumors

  This study is testing a new MRI method that helps doctors see how brain tumors respond to treatment by providing detailed information about the tumors, which could lead to better care for patients.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10814916

• Using artificial intelligence to improve treatment for multiple brain metastases

  This study is testing a new AI tool to help doctors plan better treatments for patients with multiple brain tumors, aiming to make radiation therapy more effective while keeping side effects low and improving quality of life.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10749026

• How immune responses affect triple-negative breast cancer spreading to the brain

  This work looks at how interactions between tumors and the immune system may let triple-negative breast cancer spread to the brain, with attention to differences seen in women of African ancestry.

  NIH research University of California at Davis · Davis, United States · NIH-10746898

• Investigating how tumor-immune interactions affect brain metastases in triple-negative breast cancer

  This study is looking at how triple-negative breast cancer that has spread to the brain interacts with the immune system, especially in women of African ancestry, to find out what makes the cancer spread and how it affects patients' outcomes.

  NIH research Stanford University · Stanford, United States · NIH-10735596

• Using diet changes to enhance radiation treatment for breast cancer that has spread to the brain

  This study is looking at how changing what you eat might help make radiation therapy work better for women with breast cancer that has spread to the brain, aiming to improve treatment results and reduce side effects.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-10439798

• Investigating how tumor-immune interactions affect brain metastases in triple-negative breast cancer.

  This study is looking at how tumors and the immune system work together in women with triple-negative breast cancer that has spread to the brain, especially focusing on those of African ancestry, to find new ways to improve treatment and outcomes.

  NIH research Stanford University · Stanford, United States · NIH-10411906

Related topics

Quick answers

How many Brain Metastases clinical trials are recruiting right now?

74, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (42 trials), China (13 trials), France (6 trials), Germany (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 25, Phase 1/2: 8, Phase 1: 7, Phase 3: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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