Using diet changes to enhance radiation treatment for breast cancer that has spread to the brain
Official title: (11) Diet Modification to Augment Radiation for Breast Cancer Brain Metastases
Funded at Thomas Jefferson University · NIH-10439798 · Data updated 2026-11-12
This study is looking at how changing what you eat might help make radiation therapy work better for women with breast cancer that has spread to the brain, aiming to improve treatment results and reduce side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2018 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $349,713 |
| NIH project number | 5R01CA227479-05 |
| Project ID | NIH-10439798 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with breast cancer that has spread to the brain and are undergoing radiation therapy.
✕Less likely to help
Patients who do not have breast cancer or those whose cancer has not metastasized to the brain may not benefit from this research.
What this research studies
This research investigates how dietary modifications can improve the effectiveness of radiation therapy for women with breast cancer that has metastasized to the brain. The study aims to understand the relationship between nutrition and cancer treatment outcomes, focusing on how diet can potentially enhance radiation response while reducing side effects. By exploring the metabolic changes in tumor cells, the researchers hope to empower patients with dietary strategies that could lead to better survival rates and quality of life. The ultimate goal is to integrate these dietary interventions into standard cancer care practices.
Why it matters
Potential benefit: If successful, this research could provide breast cancer patients with brain metastases a new way to enhance their treatment outcomes and reduce treatment-related toxicity.
How similar studies have gone: While dietary interventions in cancer treatment are being explored, this specific approach of combining diet modification with radiation therapy for brain metastases is relatively novel and has not been extensively tested.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Simone, Nicole L — Thomas Jefferson University
- Study coordinator: Simone, Nicole L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.