Understanding brain changes after radiation treatment for brain metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational pilot study aims to investigate the effects of stereotactic radiosurgery (SRS) on neurocognitive function in patients with newly diagnosed brain metastases. By assessing MRI biomarkers, the study will evaluate the relationship between radiation-induced brain injury and cognitive decline over one year. The research will focus on how radiation dose impacts white matter integrity and functional connectivity in the brain, providing insights that could inform treatment adjustments. The goal is to enhance understanding of the long-term cognitive effects of radiation therapy in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologic diagnosis of cancer
* Newly diagnosed brain metastasis being treated with SRS. Any extent of cranial disease permitted. Subsequent courses of SRS while on study permitted when clinically indicated.
* Patients are permitted to have undergone craniotomy and resection of metastasis/metastases if at least 1 other intact metastasis planned for definitive SRS is present. Receiving or previously received systemic therapy also permitted.
* Anticipated life expectancy at least 1 year
* Age ≥ 18 years
* Ability to read and comprehend written English and follow instructions in English
* Ability to provide informed consent

Exclusion Criteria:

* Previous radiation to the brain or head
* Previous malignancy - other than non-melanomatous skin cancer or cervical carcinoma in situ - and not disease-free for at least 3 years
* Previous severe head or brain injury
* History of a neurological disorder such as Epilepsy, Parkinson's, Alzheimer's, or Dementia
* Prisoners

Where it's running

• University of North Carolina at Chapel Hill, Department of Radiation Oncology
  Chapel Hill, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Colette J Shen, MD, PhD — University of North Carolina at Chapel Hill, Department of Radiation Oncology
• Study coordinator: Olivia Morton
• Email: olivia_roberts@med.unc.edu
• Phone: 9849748440

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.