Investigating how tumor-immune interactions affect brain metastases in triple-negative breast cancer

Who could benefit from this research

What this research studies

This research focuses on understanding the complex interactions between tumors and the immune system in patients with triple-negative breast cancer (TNBC) that has spread to the brain. By employing systems biology approaches, the study aims to uncover the molecular mechanisms that drive metastasis and contribute to cancer disparities, particularly among women of African ancestry. The research will analyze the immune environment in TNBC brain metastases to identify factors that influence metastatic potential and patient outcomes. This comprehensive approach includes a mentoring and career development plan for the principal investigator to ensure the research is conducted effectively.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Umeh Garcia, Maxine Chidinma — Stanford University
• Study coordinator: Umeh Garcia, Maxine Chidinma

Related research

Other NIH-funded projects on the same topics.

• Understanding how brain metastasis in triple-negative breast cancer is shaped by tumor-immune interactions

  A patient-focused program aims to learn why TNBC spreads to the brain and how the immune system interacts with those cancer cells, with a focus on women of African ancestry.

  NIH research University of California at Davis · Davis, United States · NIH-11411191

• How immune responses affect triple-negative breast cancer spreading to the brain

  This work looks at how interactions between tumors and the immune system may let triple-negative breast cancer spread to the brain, with attention to differences seen in women of African ancestry.

  NIH research University of California at Davis · Davis, United States · NIH-10746898

• Investigating how tumor-immune interactions affect brain metastases in triple-negative breast cancer.

  This study is looking at how tumors and the immune system work together in women with triple-negative breast cancer that has spread to the brain, especially focusing on those of African ancestry, to find new ways to improve treatment and outcomes.

  NIH research Stanford University · Stanford, United States · NIH-10411906

• Genomic study to understand how genetics and epigenetics shape triple-negative breast cancer in African ancestry

  This study looks at how inherited genes and gene activity affect triple-negative breast cancer in people of African ancestry to better understand why outcomes can be worse.

  NIH research Tuskegee University · Tuskegee Institute, United States · NIH-11621786

• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

  A study aims to block two cancer-promoting pathways (IL-6 and CDK4/6) to prevent or reduce progression of triple-negative breast cancer in women veterans.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

  Aimed at understanding how heavy metals like cadmium might trigger a dangerous breast cancer type (TNBC) in people, especially those with BRCA1 risk, to identify possible future treatment strategies.

  NIH research University of Louisville · Louisville, United States · NIH-11567535

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.