Improving MRI techniques to monitor brain metastases treatment response
Official title: Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain Metastases
Funded at Johns Hopkins University · NIH-10914899 · Data updated 2026-11-12
This study is testing a new way to use MRI scans without contrast dye to see how well brain tumors are responding to treatment, making it easier and safer for patients to track their progress over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $611,040 |
| NIH project number | 5R01CA282928-02 |
| Project ID | NIH-10914899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with brain metastases who are undergoing treatment.
✕Less likely to help
Patients with primary brain tumors or those who do not have brain metastases may not benefit from this research.
What this research studies
This research focuses on developing advanced non-contrast perfusion MRI techniques to better monitor how brain metastases respond to treatment. By utilizing methods like arterial spin labeling, the study aims to provide a more accurate and non-invasive way to assess tumor vascularity over time. This approach seeks to overcome limitations of traditional contrast-enhanced MRI, which can be affected by artifacts and may not provide precise quantification. Patients will be monitored longitudinally to track changes in their brain tumors without the need for contrast agents.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring of treatment responses in patients with brain metastases, potentially improving their outcomes.
How similar studies have gone: Previous research has shown promise in using non-contrast MRI techniques for monitoring brain tumors, indicating potential success for this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Qin, Qin — Johns Hopkins University
- Study coordinator: Qin, Qin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.